A5029361072- Muscle Physiology and Disorders
- SARS-CoV-2 and COVID-19 Research
- Plant and animal studies
- RNA Research and Splicing
- Plant Diversity and Evolution
- RNA modifications and cancer
- Fern and Epiphyte Biology
- Cancer Immunotherapy and Biomarkers
- Nutrition and Health in Aging
- COVID-19 Clinical Research Studies
- GDF15 and Related Biomarkers
- Plant Pathogens and Fungal Diseases
- Diabetes and associated disorders
- Adrenal Hormones and Disorders
Universidade de São Paulo
2024-2025
Universidade Estadual Paulista (Unesp)
2021-2024
Apis Flora (Brazil)
2018
MicroRNAs are small regulatory molecules that control gene expression. An emerging property of muscle miRNAs is the cooperative regulation transcriptional and epitranscriptional events controlling phenotype. miR-155 has been related to muscular dystrophy cell atrophy. However, function its molecular targets in dystrophies remain poorly understood. Through silico vitro approaches, we identify distinct profiles induced by miR-155-5p cells. The treated myotubes changed expression 359 genes (166...
Coronavirus disease 2019 (COVID-19) presents a wide spectrum of symptoms, the causes which remain poorly understood. This study explored associations between autoantibodies (AABs), particularly those targeting G protein-coupled receptors (GPCRs) and renin‒angiotensin system (RAS) molecules, clinical manifestations COVID-19. Using cross-sectional analysis 244 individuals, we applied multivariate variance, principal component analysis, multinomial regression to examine relationships AAB levels...
Interleukin-6 (IL-6) is a pro-inflammatory cytokine associated with skeletal muscle wasting in cancer cachexia. The control of gene expression by microRNAs (miRNAs) involves the regulation thousands target transcripts. However, miRNA-target networks IL6-induced atrophy remain to be characterized. Here, we show that IL-6 promotes C2C12 myotubes and changes 20 miRNAs (5 up-regulated 15 down-regulated). Gene Ontology analysis predicted targets revealed post-transcriptional genes involved cell...
ABSTRACT The coronavirus disease 2019 (COVID-19) displays a broad spectrum of symptoms, with the underlying reasons for this variability still not fully elucidated. Our study investigates potential association between specific autoantibodies (AABs), notably those that targeting G protein-coupled receptors (GPCRs) and renin-angiotensin system (RAS) related molecules, diverse clinical manifestations COVID-19, commonly observed in patients autoimmune conditions, including rheumatic diseases,...
Abstract MicroRNAs are small regulatory molecules that control gene expression. An emerging property of muscle miRNAs is the cooperative regulation transcriptional and epitranscriptional events controlling phenotype. miR-155 has been related to muscular dystrophy cell atrophy. However, function its molecular targets in dystrophies remain poorly understood. Through silico vitro approaches we identify distinct profile atrophy induced by miR-155-5p. The atrophic myotubes changed expression 359...