A5078256516- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- IL-33, ST2, and ILC Pathways
- COVID-19 Clinical Research Studies
- Psoriasis: Treatment and Pathogenesis
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Sympathectomy and Hyperhidrosis Treatments
- Botulinum Toxin and Related Neurological Disorders
- T-cell and B-cell Immunology
- Dermatologic Treatments and Research
- Exercise and Physiological Responses
- Autoimmune Bullous Skin Diseases
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- Trypanosoma species research and implications
- Advancements in Transdermal Drug Delivery
- Pediatric health and respiratory diseases
- Research on Leishmaniasis Studies
- Soft tissue tumors and treatment
- Herbal Medicine Research Studies
Universidade de São Paulo
2016-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2011-2023
Hospital Universitário da Universidade de São Paulo
2016
Hospital Heliópolis
2004-2009
Abstract Background Atopic dermatitis (AD) in adults and profile of skin barrier proteins inflammatory cytokines. Objective Evaluation the expression such as filaggrin, claudins 1 4 circulating cytokines (Th1/Th2/Th17) with AD. Methods Thirty‐three adult patients AD diagnosed according to Hanifin & Rajkacriteria, 25 healthy controls were enrolled study. severity was measured by Eczema Area Severity Index (EASI). Laboratory assays included immunohistochemistry analysis proteins,...
American trypanosomiasis, also named Chagas disease (CD), is an anthropozoonosis caused by the protozoan parasite Trypanosoma cruzi. The affects millions of people worldwide, leading yearly to approximately 50,000 deaths. COVID-19, generated SARS-CoV-2, can lead lymphopenia and death. We hereby describe first report two patients with CD COVID-19 coinfection, from hospitalization until patients'
Measuring outcomes in clinical practice can aid patient care, quality improvement, and real-world evidence generation. The Harmonising Outcome Measures for Eczema (HOME) Clinical Practice initiative is developing a list of validated, feasible instruments to measure atopic eczema care. Prior work identified symptoms long-term control as the most important domains practice. Patient-Oriented Measure (POEM) Scoring Atopic Dermatitis Index (PO-SCORAD) were recommended by consensus practice, but...
Janus kinase inhibitors (JAKinibs) have the potential to dramatically alter landscape of atopic dermatitis (AD) management due their promising efficacy results from phase 3 trials and rapid onset action. However, JAKinibs are not without risk, use is appropriate for all AD patients, making this a medication class that dermatologists should understand consider when treating patients with moderate-to-severe AD.
Atopic dermatitis is a highly prevalent inflammatory and pruritic dermatosis with multifactorial etiology, which includes skin barrier defects, immune dysfunction, microbiome alterations. mediated by genetic, environmental, psychological factors requires therapeutic management that covers all the aspects of its complex pathogenesis.The aim this article to present experience, opinions, recommendations Brazilian dermatology experts regarding atopic dermatitis.Eighteen from 10 university...
Chronic pruritus is the defining symptom of atopic dermatitis (AD). Although AD common in Latin America, there little data regarding intensity, characteristics, and effects on quality life this population. This cross-sectional study aimed to evaluate 91 patients with at a tertiary university hospital São Paulo, Brazil. Patients aged 14‒65-years old were included study. completed Itch Questionnaire, ItchyQoL, POEM questionnaires asked rate their itch severity using 10-point peak Numerical...
Atopic dermatitis (AD) is a chronic inflammatory immune-mediated skin disease characterized by colonization Staphylococcus aureus. Interleukin (IL)-22, in cooperation with IL-17, triggers antimicrobial peptide elaboration and enhances certain immunological responses. In AD, IL-22 related to epidermal hyperplasia, keratinocyte apoptosis, inhibition of (AMP) production. We aimed evaluate the impact staphylococcal enterotoxins on Tc22/Th22 induction peripheral blood AD patients CD4
COVID-19, the infectious disease caused by SARS-CoV-2, has spread on a pandemic scale. The viral infection can evolve asymptomatically or generate severe symptoms, influenced presence of comorbidities. Lymphopenia based severity symptoms in patients affected with COVID-19 is frequent. However, profiles CD4+ and CD8+ T cells regarding cytotoxicity antiviral factor expression have not yet been completely elucidated acute SARS-CoV-2 infections. purpose this study was to evaluate phenotypic...
Abstract Background Atopic dermatitis ( AD ) is a chronic recurrent inflammatory disease, with prevalence of about 10–20% in children and 1–3% adults. S taphylococcus aureus present 80–100% skin from atopic patients related to worsening the disease by action enterotoxins. The aim this study was evaluate profile anti‐ enterotoxin B SEB antibody isotypes IgG subclass levels adult . Methods We selected 38 , diagnosed H anifin R ajka's criteria, aged between 18 65, 26 healthy controls HC )....
Atopic dermatitis (AD) is a chronic inflammatory disease causing intense pruritus, and with typical clinical features. There are few epidemiological studies concerning AD in adults, as well little information about its prognostic. The aim of this study was to evaluate the course adults AD. 80 patients aged above 18 years (mean age = 29 years) were selected (30 males 50 females) interviewed hospitalization, systemic corticoid usage, onset, personal and/or familial history atopy. Disease...
Our group recently demonstrated that IgG modulates αβT cell cytokine production during the maturation process in human thymus. The effects of this modulation are repertoire dependent and can exert a systemic long-term impact.To investigate whether from atopic dermatitis (AD) patients modulate infant intrathymic TCD4 TCD8 cells vitro.Thymic tissues were obtained newborn children nonatopic mothers, thymocytes cultured for 6 days with purified AD or intravenous immunoglobulin (IVIG) mock...
Abstract Background Atopic dermatitis (AD) pathogenesis still needs to be elucidated, but invariant natural killer T (iNKT) cell involvement was already described by several groups. Our group has demonstrated that IgG antibodies purified from AD patients can modulate cytokine production thymic cells. Here we aimed investigate if infant non‐atopic iNKT cells in order collaborate with the elucidation of development infancy. Methods Thymic tissues were obtained children mothers, and diagnosed...
Atopic dermatitis (AD) is a common relapsing inflammatory skin disorder characterized by immune-mediated inflammation and epidermal barrier dysfunction. The pathogenesis of AD multifactorial has not been fully elucidated to date. This study aimed evaluate whether serum IgG from adult patients could modulate the thymic maturation IL-22-producing T cells CLA+ non-atopic infants. Given that miRNAs regulate immune response genes, we evaluated miRNA expression also altered in cultured thymocytes....
Atopic dermatitis (AD) is a chronic, inflammatory skin disease with high prevalence and complex pathogenesis. The of AD patients usually colonized by Staphylococcus aureus (S. aureus); its exotoxins may trigger or enhance the cutaneous inflammation. Several mediators are related to immune imbalance interleukin-18 (IL-18), an cytokine, play role in atopic inflammation.To evaluate peripheral blood mononuclear cells (PBMC) proliferation response staphylococcal enterotoxins A (SEA) B (SEB)...
Abstract Staphylococcus aureus colonizes the skin of atopic dermatitis (AD) individuals, but impact its enterotoxins on chronic activation CD4 + T cells demands further analysis. We aimed to analyze cell anergy profile and their phenotypic functional features through differential expression cellular markers, cytokine production response staphylococcal enterotoxin A (SEA). panel 84 genes relevant was assessed by PCR array in FACS-sorted cells, most prominent were validated RT-qPCR. evaluated...
Common clinical features of patients with Coronavirus disease-2019 (COVID-19) vary from fever, to acute severe respiratory distress syndrome. Several laboratory parameters are reported as indicators COVID-19 severity. We hereby describe the possible novel severity biomarkers for COVID-19, CD11b+CD33+HLA-DR-CD14+ cells and CD11b+CD33+HLA-DR-CD66b+ cells.
The infection by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can generate a wide spectrum of clinical manifestations ranging from asymptomatic to and systemic disease with coagulation disorder named coronavirus 2019 (COVID-19). Patients comorbidities have been identified as risk groups for COVID-19, also having higher death risk. Previous reports conflicting results regarding if solid organ transplant recipients present an increased COVID-19. Nevertheless, previous...