Lícia C. Silva-Costa
A5014067941- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Proteomics Techniques and Applications
- Cannabis and Cannabinoid Research
- Stress Responses and Cortisol
- COVID-19 and Mental Health
- Treatment of Major Depression
- Metabolomics and Mass Spectrometry Studies
- Blood properties and coagulation
- Immune responses and vaccinations
- Nuclear Receptors and Signaling
- Single-cell and spatial transcriptomics
- Diet, Metabolism, and Disease
- Genetics, Aging, and Longevity in Model Organisms
- Gene expression and cancer classification
- Youth, Drugs, and Violence
- Pancreatic function and diabetes
- Mass Spectrometry Techniques and Applications
- Ubiquitin and proteasome pathways
- Iron Metabolism and Disorders
- Biotin and Related Studies
- Histone Deacetylase Inhibitors Research
Universidade Estadual de Campinas (UNICAMP)
2017-2024
Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, long-term dysfunction (recently characterized as part of "long COVID-19" syndrome) has been frequently observed after mild infection. We show the spectrum cerebral impact acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranging from alterations in mildly infected individuals (orbitofrontal cortical atrophy, neurocognitive impairment, excessive fatigue and anxiety...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such lymphocytopenia cytokine storm, which are associated with severity predict mortality. mechanism by infection result in immune system dysfunction still not fully understood. Here, we show that human CD4+ T helper cells, but CD8+ present blood...
Abstract Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, the long-term dysfunction has been frequently observed after mild infection. Here we show spectrum of cerebral impact SARS-CoV-2 infection ranging from alterations in mildly infected individuals (orbitofrontal cortical atrophy, neurocognitive impairment, excessive fatigue and anxiety symptoms) to acute damage confirmed brain tissue samples extracted orbitofrontal...
Abstract COVID-19 patients may exhibit neuropsychiatric and neurological symptoms. We found that anxiety cognitive impairment are manifested by 28-56% of SARS-CoV-2-infected individuals with mild respiratory symptoms associated altered cerebral cortical thickness. Using an independent cohort, we histopathological signs brain damage in 25% who died COVID-19. All the affected tissues exhibited foci SARS-CoV-2 infection replication, particularly astrocytes. Infection neural stem cell-derived...
The development of new approaches allowing for the early assessment COVID-19 cases that are likely to become critical and discovery therapeutic targets urgently required. In this prospective cohort study, we performed proteomic laboratory profiling plasma from 163 patients admitted Bauru State Hospital (Brazil) between 4 May 2020 July 2020. Plasma samples were collected upon admission routine analyses shotgun quantitative label-free proteomics. Based on course disease, divided into three...
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak tract disease known as disease-2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such lymphocytopenia cytokine storm, which are associated with severity predict mortality 1,2 . mechanism by infection result in immune system dysfunction still not fully understood. Here we show that human CD4 + T helper cells, but CD8 present blood...
Abstract The COVID-19 pandemic was initiated by the rapid spread of a SARS-CoV-2 strain. Though mainly classified as respiratory disease, infects multiple tissues throughout human body, leading to wide range symptoms in patients. To better understand how affects proteome from cells with different ontologies, this work generated an infectome atlas 9 cell models, including brain, blood, digestive system, and adipocyte tissue. Our data shows that infection trigger dysregulations on proteins...
Abstract There is a constant interest in blood‐based protein biomarkers, which can help to improve diagnosis and treatment outcomes of multifactorial human pathologies. In this regard, proteomic studies usually employ plasma immunoaffinity fractionation deplete the most abundant proteins, due high dynamic concentration range proteins. The depletion proteins allows obtain less and, oftentimes, more interesting However, removal fraction ‐ depletome may co‐elute many unintended protein‐protein...
Cannabidiol, a compound of Cannabis sativa , has been proposed as an alternative treatment schizophrenia. Preclinical and clinical data have suggested that cannabidiol shares more similarity with atypical antipsychotics than typical, both which are customarily used to manage schizophrenia symptoms. While oligodendrocytes known be relevant targets antipsychotics, the biochemical knowledge in this regard is still limited. Here we evaluated molecular pathways modulated by compared clozapine...