A5076515187- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Optical Coherence Tomography Applications
- Cerebrovascular and Carotid Artery Diseases
- Retinal and Macular Surgery
- Cardiac Imaging and Diagnostics
- Artificial Intelligence in Healthcare
- Digital Imaging for Blood Diseases
- Acute Ischemic Stroke Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular Function and Risk Factors
- Advanced Memory and Neural Computing
- Photoacoustic and Ultrasonic Imaging
- Statistical Methods in Clinical Trials
- Cardiovascular Disease and Adiposity
- Peripheral Artery Disease Management
- Medical and Biological Ozone Research
- Orthodontics and Dentofacial Orthopedics
- Neuroscience and Neural Engineering
- CCD and CMOS Imaging Sensors
- Optical Imaging and Spectroscopy Techniques
- Asthma and respiratory diseases
- Hemodynamic Monitoring and Therapy
Fundação Oswaldo Cruz
2025
Universidade Federal de Viçosa
2025
Amgen (United States)
2025
Association for Innovation and Biomedical Research on Light and Image
2015-2024
Joslin Diabetes Center
2022
Harvard University
2022
Biomedical Research and Innovation Institute of Cadiz
2022
Instituto Português de Oncologia de Coimbra Francisco Gentil
2008-2017
University of Coimbra
2011-2012
Institute of Biophysics
2010
Quantitative measurements based on optical coherence tomographic angiography (OCTA) may have value in managing diabetic retinopathy (DR), but there is limited information the ability of OCTA to distinguish eyes with DR.To evaluate retinal microvasculature using healthy from DR.In this prospective cross-sectional study, was used examine participants type 2 diabetes or without DR and September 17, 2015, April 6, 2016. Density maps superficial layer (SRL) deeper (DRL) images were generated...
<h3>Purpose</h3> To analyse and compare the classification of eyes with diabetic retinopathy using fluorescein angiography (FA) optical coherence tomography (OCTA) performed either AngioPlex or AngioVue. <h3>Methods</h3> This was an observational cross-sectional study 50 from 26 subjects. Two independent graders classified FA angiograms, to assess presence severity several characteristics according ETDRS Report 11, a similar evaluation for each 3×3 mm OCTA image superficial retinal layer...
<b><i>Purpose:</i></b> To identify the retinal layer predominantly affected in eyes with subclinical and clinical macular edema diabetes type 2. <b><i>Methods:</i></b> A cohort of 194 2 diabetic eyes/patients mild nonproliferative retinopathy (ETDRS levels 20/35) were examined Cirrus spectral-domain optical coherence tomography (OCT) at baseline visit (ClinicalTrials.gov identifier: NCT01145599). Automated segmentation layers was compared a...
The objective of this study was to evaluate the prevalence different disease pathways (ischemia, neurodegeneration, and edema) in initial stages diabetic retinopathy. In retrospective cross-sectional study, eyes were grouped by retinopathy severity using 7-field Early Treatment Diabetic Retinopathy Study (ETDRS) protocol (levels 10-20, 35, 43-47). Neurodegeneration identified thinning retinal nerve fiber layer and/or ganglion cell layer. Edema thickening inner nuclear layer, outer plexiform...
Purpose: To characterize 2-year changes occurring in neurodegeneration, edema, and capillary dropout nonproliferative diabetic retinopathy. Methods: Two-year prospective longitudinal observational cohort of eyes/patients with type 2 diabetes using spectral domain optical coherence tomography (SD-OCT) angiography (OCTA). Eyes were examined three times intervals 1 year. Thickness the full retina layer-by-layer measurements used to identify edema or neurodegeneration. OCTA vessel density maps...
Purpose To test whether a single or composite set of parameters evaluated with optical coherence tomography angiography (OCTA), representing retinal capillary closure, can predict non-proliferative diabetic retinopathy (NPDR) staging according to the gold standard ETDRS grading scheme. Methods 105 patients diabetes, either without different degrees (NPDR up grade 53), were prospectively using swept-source OCTA (SS-OCTA, PlexElite, Carl Zeiss Meditec) 15×9 mm and 3×3 protocols. Seven-field...
To evaluate the effects of anti-vascular endothelial growth factor treatment on retinal fluid in patients with diabetic macular edema by using optical coherence tomography leakage (OCT-L), a new method quantifying sites lower than normal reflectivity (LOR) OCT, and to correlate these findings best-corrected visual acuity (BCVA) response.Prospective analysis 21 eyes edema, naive treatment. Macular cube 512 × 128 OCT angiography 6 6-mm scans (CIRRUS AngioPlex; ZEISS, Dublin, CA) were acquired...
Purpose: To identify retinal extracellular fluid changes and their correlation with increased thickness (RT) in eyes subclinical clinical macular edema diabetes type 2. Methods: A cohort of 48 from 2 diabetic patients mild or moderate nonproliferative retinopathy (Early Treatment Diabetic Retinopathy Study levels 20/35) were classified as having normal RT (10), (30), (8). They examined Cirrus spectral-domain optical coherence tomography (OCT) at baseline visits (ClinicalTrials.gov number,...
Purpose: To identify progression of nonproliferative diabetic retinopathy (NPDR) in patients with type 2 diabetes by combining optical coherence tomography angiography (OCTA) metrics and color fundus photography (CFP) images. Methods: This study was a post hoc analysis prospective longitudinal cohort (CORDIS, NCT03696810) 2-year duration. enrolled 122 eyes. Ophthalmological examinations included OCTA CFP. skeletonized vessel density (SVD) perfusion (PD) at the superficial capillary plexus...
The dairy industry faces challenges in controlling spoilage microorganisms, particularly Pseudomonas, known to form resilient biofilms. Conventional disinfection methods have limitations, prompting the exploration of eco-friendly alternatives like ozone. This study focused on Pseudomonas biofilms polystyrene and polyethylene surfaces, evaluating ozone efficacy when incorporated into different water sources applied under static dynamic conditions. Biofilm formation removal were assessed with...
Our group reported that three diabetic retinopathy (DR) phenotypes: A, characterized by low microaneurysm turnover (MAT < 6) and normal central retinal thickness (CRT); B, MAT (<6) increased CRT, C, high (≥6), present different risks for development of macular edema (DME) proliferative (PDR). To test these findings, 212 persons with type 2 diabetes (T2D) mild nonproliferative (NPDR), one eye per person, were followed five years annual visits. Of these, 172 completed the follow-up or...
The aim of this study was to explore the relation between retinal neurodegenerative changes and vessel closure (VC) in individuals with nonproliferative diabetic retinopathy (NPDR) a follow-up period 3 years.This is 3-year prospective longitudinal four annual visits.This involved 74 type 2 diabetes, NPDR, Early Treatment Diabetic Retinopathy Study grades from 10 47, one eye/person. An age-matched healthy control population 84 eyes used as group.Participants were annually examined by color...
To compare the location of sites lower reflectivity, as determined by OCT leakage using spectral domain (SD)-OCT, with fluorescein identified angiography (FA) in eyes diabetic retinopathy.Prospective consecutive case series.Fifty-two from 28 patients type 2 diabetes and presence nonproliferative retinopathy.All were imaged FA SD-OCT (Angioplex, Carl Zeiss Meditec, Inc). All images analyzed experienced graders, area surrounding well-defined was outlined graders. The scans processed...
<b><i>Purpose:</i></b> To characterize the 1-year progression of retinal thickness (RT) increase occurring in eyes with subclinical macular edema type 2 diabetes. <b><i>Methods:</i></b> Forty-eight diabetic eyes/patients mild nonproliferative retinopathy (NPDR; levels 20 and 35 Early Treatment Diabetic Retinopathy Study) classified as presenting at baseline completed follow-up period, from a sample 194 followed 12-month observational...
Abstract Purpose To characterize the progression in retinopathy severity of different phenotypes mild nonproliferative diabetic (NPDR) patients with type 2 diabetes. Design and methods Patients diabetes NPDR (ETDRS 20 or 35) were followed a 5-year longitudinal study. Examinations, including color fundus photography (CFP) optical coherence tomography (OCT OCTA), performed at baseline, 6 months then annually. Phenotype classification was based on microaneurysm turnover (MAT, CFP) central...
To examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) severity progression a three-year period. Methods: Three-year prospective longitudinal observational cohort individuals with type 2 diabetes (T2D), one eye per person, using spectral domain-optical coherence tomography (SD-OCT) OCT-Angiography (OCTA). Eyes were examined four times one-year intervals. OCTA density maps retina used to quantify...
The aim of the study was to identify retinal microvascular changes using optical coherence tomography angiography (OCTA) in type 2 diabetes (T2D) patients with preclinical retinopathy identified by ultra-widefield fundus photography (UWF-FP).This is a cross-sectional observational study. All underwent UWF-FP 200° examinations OPTOS California (Optos, Dunfermline, UK) and Cirrus AngioPlex® spectral-domain (SD)-OCTA 3 × mm acquisitions (ZEISS, Dublin, CA, USA). absence visible lesions...
To demonstrate the association between changes in blood-retinal barrier (BRB) identified by fluorescein leakage and those optical properties of human retina determined coherence tomography (OCT) show how these can be quantified their location within retina.Two imaging techniques were applied: retinal analyzer, to map BRB function into intact or disrupted regions, OCT, measure refractive index along light path ocular fundus.A total 140 comparisons made, 77 areas regions receiving same...
The use of synthetic images is needed for testing the performance image processing methods in order to establish a ground truth test metrics. However, these do not represent real applications. aim this paper build mathematical model obtain noise-free mimicking Optical Coherence Tomography (OCT) B-scan or volume from human retina, filtering metrics context. Moreover we also suggest method add speckle noise based on given OCT volume. In way replicable that actually mimics case.
Optical coherence tomography (OCT) is becoming one of the most important imaging modalities in ophthalmology due to its non-invasiveness and by allowing visualisation human retina structure detail. It was recently proposed that OCT data embeds functional information from retina. Specifically, it blood-retinal barrier status present within Besides this ability, authors supporting idea having encoding ageing addition disease (diabetes) condition healthy status. The methodology followed makes...
Purpose: To determine the degree of central microvascular closure using optical coherence tomography angiography (OCTA) in eyes type 2 diabetes patients with visible lesions only retina or periphery. Methods: Cross-sectional study. All 127 underwent Ultra-Widefield Fundus Photography (UWF-FP) 200° examinations OPTOS California (Optos, Dunfermline, UK) and Cirrus Angioplex OCT-Angiography 3x3mm acquisitions (ZEISS, Dublin, CA, USA). Results: Twenty-five showed (inside 7-ETDRS fields area), 57...
The automatic segmentation of the retinal vascular network from ocular fundus images has been performed by several research groups. Although different approaches have proposed for traditional imaging modalities, only a few addressed this problem optical coherence tomography (OCT). Furthermore, these were focused on optic nerve head region. Compared to color photography and fluorescein angiography, two-dimensional reference computed three-dimensional OCT data present additional problems...