Letícia Pastorelli Bonjorno
A5009392932- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Phagocytosis and Immune Regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Salivary Gland Disorders and Functions
- Clinical Reasoning and Diagnostic Skills
- Rheumatoid Arthritis Research and Therapies
- Immune responses and vaccinations
- Systemic Lupus Erythematosus Research
- Dermatological and COVID-19 studies
- Kawasaki Disease and Coronary Complications
- Neurological disorders and treatments
- Medical Malpractice and Liability Issues
- Botulinum Toxin and Related Neurological Disorders
- Blood properties and coagulation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Male Reproductive Health Studies
- Inflammation biomarkers and pathways
- Diabetes Management and Education
- Malaria Research and Control
- Vector-borne infectious diseases
- Neurological and metabolic disorders
- Adipokines, Inflammation, and Metabolic Diseases
Universidade de São Paulo
2019-2023
Clinics Hospital of Ribeirão Preto
2019-2021
Fundação Padre Albino
2020
Centro de Reprodução Humana Prof. Franco Junior
2020
Universidade de Ribeirão Preto
2019
Seevic College
2019
Universidade Estadual de Londrina
2017
Universidade Estadual de Maringá
2016
Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering neutrophil extracellular traps (NETs) have been described as important mediators of tissue damage in inflammatory diseases, we investigated whether NETs would be involved pathophysiology. A cohort 32 hospitalized with a confirmed diagnosis healthy controls were enrolled. The concentration was augmented plasma, tracheal aspirate, lung...
Severe cases of COVID-19 are characterized by a strong inflammatory process that may ultimately lead to organ failure and patient death. The NLRP3 inflammasome is molecular platform promotes inflammation via cleavage activation key molecules including active caspase-1 (Casp1p20), IL-1β, IL-18. Although participation the in has been highly speculated, outcome disease unknown. Here we demonstrate activated response SARS-CoV-2 infection patients. Studying moderate severe patients, found PBMCs...
Objective To evaluate whether the addition of colchicine to standard treatment for COVID-19 results in better outcomes. Design We present a randomised, double-blinded, placebo-controlled clinical trial moderate severe COVID-19, with 75 patients allocated 1:1 from 11 April 30 August 2020. Colchicine regimen was 0.5 mg thrice daily 5 days, then twice days. The primary endpoints were need supplemental oxygen, time hospitalisation, admission and length stay intensive care unit death rate....
Although SARS-CoV-2 severe infection is associated with a hyperinflammatory state, lymphopenia an immunological hallmark, and correlates poor prognosis in COVID-19. However, it remains unknown if circulating human lymphocytes monocytes are susceptible to infection. In this study, of peripheral blood mononuclear cells (PBMCs) was investigated both vitro vivo . We found that whole PBMCs from healthy donors productive virus progeny. Results revealed monocytes, as well B T lymphocytes, active...
Abstract Background The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases COVID-19. However, the molecular mechanisms underlying NETs COVID-19 remain unclear. Objectives We aim to investigate role Gasdermin-D (GSDMD) pathway on development during Methods performed a single-cell transcriptome analysis public data bronchoalveolar lavage. Then, we enrolled 63 hospitalized patients moderate analyze blood lung...
COVID-19 is a disease of dysfunctional immune responses, but the mechanisms triggering immunopathogenesis are not established. The functional plasticity macrophages allows this cell type to promote pathogen elimination and inflammation or suppress tissue remodeling injury repair. During an infection, clearance dead dying cells, process named efferocytosis, can modulate interplay between these contrasting functions. Here, we show that engulfment SARS-CoV-2-infected apoptotic cells exacerbates...
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a hyperinflammatory state and lymphocytopenia, hallmark that appears as both signature prognosis of disease severity outcome. Although cytokine storm sustained inflammatory are commonly immune cell depletion, it still unclear whether direct SARS-CoV-2 cells could also play role in this scenario by harboring viral replication. We found monocytes, well B T lymphocytes, were susceptible to...
Abstract Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to failure. These also cytokine storm syndrome, and organ dysfunctions, which is a clinical picture resembles sepsis. Considering neutrophil extracellular traps (NETs) have been described as an important factors of tissue damage in sepsis, we investigated whether NETs would be produced participate the lung damage. A cohort 32 hospitalized with confirmed diagnosis respective healthy controls were...
ABSTRACT Introduction Neutrophilia and high levels of proinflammatory cytokines other mediators inflammation are common finds in patients with severe acute respiratory syndrome due to COVID-19. By its action on leukocytes, we propose colchicine as an intervention worthy being tested. Objective To evaluate whether the addition standard treatment for COVID-19 results better outcomes. Methods We present interim analysis a single-center randomized, double-blinded, placebo controlled clinical...
Abstract Severe cases of COVID-19 are characterized by a strong inflammatory process that may ultimately lead to organ failure and patient death. The NLRP3 inflammasome is molecular platform promotes inflammation via cleavage activation key molecules including active caspase-1 (Casp1p20), IL-1β IL-18. Although the participation in has been highly speculated, outcome disease unknown. Here we demonstrate activated response SARS-CoV-2 infection it COVID-19, influencing clinical disease....
Studies show that educational interventions improve glycemic control in patients with diabetes mellitus (DM), reducing the occurrence of complications associated disease. To evaluate effects a mobile DM consultancy on clinical and laboratory parameters, disease knowledge, quality life type 2 (T2DM) at primary health care network Brazil. Randomized trial conducted city southern Brazil 52 T2DM receiving setting. The intervention lasted for 6 months consisted follow-up an endocrinologist (five...
Abstract COVID-19 is a disease of dysfunctional immune responses, but the mechanisms triggering immunopathogenesis are not established. The functional plasticity macrophages allows this cell type to promote pathogen elimination and inflammation or suppress tissue remodeling injury repair. During an infection, clearance dead dying cells, process named efferocytosis, can modulate interplay between these contrasting functions. Here, we show that engulfment SARS-CoV2-infected apoptotic cells...
Abstract The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases COVID-19. However, the molecular mechanisms underlying NETs COVID-19 remain unclear. Using a single-cell transcriptome analysis we observed that expression GSDMD inflammasome-related genes were increased neutrophils from patients. Furthermore, high was structures lung tissue activation requires live SARS-CoV-2 occurs after infection via ACE2...
The aim of this study was to evaluate the concordance diagnoses made by senior rheumatologists and those residents in rheumatology general practitioners (GPs).In cohort, 497 patients referred GPs from August 1, 2018 December 16, 2019 were evaluated first a second-year resident rheumatology. After clinical rounds, assumed as criterion standard defined prevalence rheumatic diseases, divided into 5 groups: rheumatoid arthritis, spondyloarthritis, other connective tissue diseases vasculitis,...
A doença por coronavírus de 2019 (COVID-19), causada pelo 2 da síndrome respiratória aguda grave (SARS-CoV-2), afetou milhões pessoas em todo o mundo, precipitando um esforço comunidade científica para compreender sua fisiopatologia. Nosso intuito neste artigo é revisar os aspectos envolvidos nas respostas imunes inata e adaptativa geradas pela infecção reconhecidos até presente momento, assim como a imunopatologia implicada pior desfecho, como, partir desse conhecimento obtido, novas...
Brazilian Lyme-simile disease or Baggio-Yoshinari syndrome is an infectious difficult to diagnose due the variable clinical presentation and inability of in vitro isolation Borrelia burgdorferi sensu stricto transmitted by tick bites. In addition migratory erythema (ME), acute stage, there are frequent constitutional, musculoskeletal neurological complications. The latent late stages unusual report contact with tick, have neurological, cardiac joint manifestations. Diagnostic criteria...
Musculoskeletal symptoms are the leading cause of demand for medical care at primary health level, where physicians often have insufficient skills diagnose and treat rheumatic diseases. The aims were to evaluate diagnostic concordance diseases between tertiary levels by comparing diagnosis present in Public Health System (PHS) referral letters obtained rheumatologists from a service.
Early diagnosis and therapeutic intervention aimed at remission of the inflammatory process improves prognosis in rheumatic diseases. In order to recognize early rheumatoid arthritis (RA), EULAR defined clinical characteristics patients with arthralgia considered be risk for AR development. Similarly, ASAS group relevant evaluation low back pain, contributing spondyloarthritis (Spa). The objective was apply questionnaires general population track individuals higher developing RA Spa.
Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease, characterized by the involvement of exocrine glands, xerophthalmia and xerostomia. It may occur as primary SS or combined with another rheumatic immunomediated secondary Sjögren’s (sSS), such Systemic Lupus Erythematosus (SLE), Sclerosis (SE) Rheumatoid Arthritis (RA). This association promotes distinct clinical variants, less severe presentation in SLE-sSS more RA-sSS, peculiarities autoantibody profile minor salivar...
INTRODUCTION: Sicca-syndrome and Sjögren Syndrome (SS) were used as synonymous until recently years, when efforts made to clarify the subjacent causes, mechanisms propose criteria separate diseases. Sicca is generally use dry eyes mouth symptoms without specifying underlying etiology. It composes classic presentation of SS but can also be triggered by medications, hormones alterations, systemic metabolic infectious or inflammatory OBJECTIVE: To characterize patients with Sjögren's syndrome...