A5090956910- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- RNA and protein synthesis mechanisms
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Genomics and Phylogenetic Studies
- Mycobacterium research and diagnosis
- Adipose Tissue and Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammasome and immune disorders
- Esophageal and GI Pathology
- Maternal and Neonatal Healthcare
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- T-cell and B-cell Immunology
- Respiratory Support and Mechanisms
- History of Medical Practice
- Breastfeeding Practices and Influences
- Craniofacial Disorders and Treatments
- Nutrition and Health in Aging
- Fibroblast Growth Factor Research
- Maternal and Perinatal Health Interventions
- Women's cancer prevention and management
- Drug Transport and Resistance Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Universidade de São Paulo
1987-2025
Universidade de Ribeirão Preto
2022
Abstract Background The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases COVID-19. However, the molecular mechanisms underlying NETs COVID-19 remain unclear. Objectives We aim to investigate role Gasdermin-D (GSDMD) pathway on development during Methods performed a single-cell transcriptome analysis public data bronchoalveolar lavage. Then, we enrolled 63 hospitalized patients moderate analyze blood lung...
Abstract The hormonal decline during menopause increases women's risk of chronic diseases. D-limonene, a monoterpene found in the human diet, possesses biological properties related to hypolipemic, antioxidant, anti-inflammatory, and gut microbiota-modulating activities, primarily observed preclinical studies. Postprandial responses include physiological adaptations stress nutrient surplus, providing an opportunity assess metabolic resilience, being suitable strategy for exploring...
Highlights•Body Mass index-correlated genes suggest the impact of immunometabolism in severe COVID-19.•Expression 15 metabolism and immune-related was exclusively induced lungs obese COVID-19 patients.•Metabolic changes antiviral immunity may increase inflammation patients.SummaryBackground & aimsObesity is associated with low grade systemic insulin resistance. Although metabolic immunological contribute to increased risk for mortality obese, little known about obesity patients...
ABSTRACT In the 2018 yellow fever (YF) outbreak in Brazil, we generated new transcriptomic data and combined it with clinical immunological to decode pathogenesis of YF. Analyzing 79 patients, found distinct gene expression patterns between acute YF, other viral infections, milder YF‐17D vaccine infection. We identified a critical role for low‐density, immature neutrophils severe outcomes, marked by downregulation genes essential neutrophil migration maturation, such as PADI4, CSF3R, ICAM1,...
Abstract The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases COVID-19. However, the molecular mechanisms underlying NETs COVID-19 remain unclear. Using a single-cell transcriptome analysis we observed that expression GSDMD inflammasome-related genes were increased neutrophils from patients. Furthermore, high was structures lung tissue activation requires live SARS-CoV-2 occurs after infection via ACE2...
Background and Objectives: Bile acids (BA) are recognized as metabolic integrators that participate in the regulation of energy metabolism inflammation. Their concentration plasma increases several-fold after a meal. The postprandial period is characterized by physiological changes to accommodate alterations nutrient availability systemic inflammatory response. An animal model would be an important tool investigate metabolism, but there no fully model, it uncertain whether human responses...
Summary In the 2018 yellow fever (YF) outbreak in Brazil, we generated new transcriptomic data and combined it with clinical immunological to decode pathogenesis of YF. Our analysis 79 patients highlighted distinct gene expression patterns between acute YF infections, other viral milder infection induced by live-attenuated YF-17D vaccine. We identified a critical role for low-density, immature neutrophils severe outcomes, marked downregulation genes such as PADI4, CSF3R, ICAM1 deceased...
Abstract Thyroid autoimmune diseases, such as Hashimoto thyroiditis and Graves disease, are significantly more prevalent in women than men, suggesting underlying biological differences immune system function regulation between sexes. Plasma B cells crucial autoimmunity due to their role producing antibodies targeting self-antigens, but presence the thyroids of without clinical diseases remains largely unexplored. This study investigates infiltration plasma female specifically excluding those...
Pathogens can cause a wide variety of infectious diseases. The biological processes induced by the host in response to infection determine severity disease. To study such processes, researchers use high-throughput sequencing techniques (RNA-seq) that measure dynamic changes transcriptome at different stages infection, clinical outcomes, or disease severity.This investigation lead better understanding diseases, as well uncovering potential drug targets and treatments. protocol presented here...
Pathogens can cause a wide variety of infectious diseases. The biological processes induced by the host in response to infection determine severity disease. To study such processes, researchers use high-throughput sequencing techniques (RNA-seq) that measure dynamic changes transcriptome at different stages infection, clinical outcomes, or disease severity.This investigation lead better understanding diseases, as well uncovering potential drug targets and treatments. protocol presented here...
Bello, C N M.D.; Mathias, L Torres, M A Vasconcelos, Amaral, R VG F.A.C.A. Author Information