A5001680547- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Neonatal and fetal brain pathology
- Neurobiology of Language and Bilingualism
- MRI in cancer diagnosis
- Traumatic Brain Injury Research
- Health disparities and outcomes
- Infant Development and Preterm Care
- Neural dynamics and brain function
- Lysosomal Storage Disorders Research
- Virus-based gene therapy research
- Neurological Disease Mechanisms and Treatments
- RNA regulation and disease
- Mental Health Research Topics
- Stuttering Research and Treatment
- Medical Image Segmentation Techniques
- Radiomics and Machine Learning in Medical Imaging
- Genetic Associations and Epidemiology
- Ginkgo biloba and Cashew Applications
New Zealand Brain Research Institute
2016-2025
University of Canterbury
2008-2025
University of Otago
2015-2025
Pacific Radiology (New Zealand)
2013-2025
Christchurch Hospital
2013-2024
Brain Research New Zealand
2018-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020
University of Vermont
2013
<h3>Objective:</h3> To establish the diagnostic accuracy of Montreal Cognitive Assessment (MoCA) when screening externally validated cognition in Parkinson disease (PD), by comparison with a PD-focused test (Scales for Outcomes disease–Cognition [SCOPA-COG]) and standardized Mini-Mental State Examination (S-MMSE) as benchmarks. <h3>Methods:</h3> A convenience sample 114 patients idiopathic PD 47 healthy controls was examined movement disorders center. The 21 dementia (PD-D) were diagnosed...
Intrinsic connectivity, measured using resting-state fMRI, has emerged as a fundamental tool in the study of human brain. However, due to practical limitations, many studies do not collect enough data generate reliable measures intrinsic connectivity necessary for studying individual differences. Here we present general functional (GFC) method leveraging shared features across and task fMRI demonstrate Human Connectome Project Dunedin Study that GFC offers better test-retest reliability than...
Objective Mild cognitive impairment and dementia are common non-motor features of Parkinson's disease (PD). The aim this study was to characterise grey matter changes associated with clearly defined stages in PD using structural MRI. Methods 96 subjects were classified detailed testing as normal cognition (PD-N, n=57), mild (PD-MCI, n=23) or (PD-D, n=16); 34 controls matched for mean age sex ratio also participated. Grey volume differences evaluated voxel based morphometry segments derived...
Abstract An individual’s brainAGE is the difference between chronological age and predicted from machine-learning models of brain-imaging data. BrainAGE has been proposed as a biomarker age-related deterioration brain. Having an older linked to Alzheimer’s, dementia, mortality. However, these findings are largely based on cross-sectional associations which can confuse differences with cohort differences. To illuminate validity accelerated brain aging, study needed large all born in same year...
There is a need for objective imaging markers of Parkinson's disease status and progression. Positron emission tomography single photon computed studies have suggested patterns abnormal cerebral perfusion in as potential functional biomarkers. This study aimed to identify an arterial spin labelling magnetic resonance-derived network accessible, non-invasive alternative. We used pseudo-continuous measure grey matter 61 subjects with range motor cognitive impairment, including patients...
To characterize different stages of Parkinson disease (PD)-related cognitive decline using diffusion tensor imaging (DTI) and investigate potential relationships between cognition microstructural integrity primary white matter tracts.Movement Disorder Society criteria were used to classify 109 patients with PD as having normal (PD-N, n = 63), mild impairment (PD-MCI, 28), or dementia (PD-D, 18), compared 32 matched controls. DTI indices assessed across groups tract-based spatial statistics,...
There is growing interest in identifying Parkinson's disease (PD) patients with mild cognitive impairment (PD-MCI), but widely disparate criteria have been used. We assessed 143 PD and 50 matched controls on 20 measures across 4 domains (executive function, attention working memory, learning visuoperception). Twenty-four met for dementia (PD-D); nondementia were classified as either normal cognition or MCI 12 neuropsychological criteria. compared the influence of these distribution global...
ABSTRACT Background Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated. Objective Using a multicenter approach and harmonized analysis methods, we aimed shed light on stage‐specific profiles pathology, as suggested by in vivo neuroimaging. Methods Individual brain MRI clinical data from 2357 patients 1182 healthy controls were collected 19 sources. We analyzed regional cortical thickness, surface area, subcortical volume using...
White matter hyperintensities proliferate as the brain ages and are associated with increased risk for cognitive decline well Alzheimer's disease related dementias. As such, white have been targeted a surrogate biomarker in intervention trials older adults. However, it is unclear at what stage of aging begin to relate cognition if they may be viable target early prevention. In Dunedin Study, population-representative cohort followed since birth, we measured 843 45-year-old participants using...
Objective: Neuroimaging research has revealed that structural brain alterations are common across broad diagnostic families of disorders rather than specific to a single psychiatric disorder. Such overlap in the correlates mental mirrors already well-documented phenotypic comorbidity symptoms and diagnoses, which can be indexed by general psychopathology or p factor. The authors hypothesized if drives convergence disorders, then 1) there should few associations unique any one family 2) with...
Significance We followed a population-representative cohort of children from birth to their mid-forties. As adults, with better self-control aged more slowly in bodies; showed fewer signs brain aging; and were equipped manage later-life health, financial, social demands. The effects children’s separable socioeconomic origins intelligence. Children changed rank order across age, suggesting the hypothesis that it is malleable intervention target. Adults’ was associated aging outcomes...
The presence and extent of structural changes in the brain as a consequence Parkinson's disease (PD) is still poorly understood. High-resolution 3-tesla T1-weighted magnetic resonance images sixty-five PD 27 age-matched healthy control participants were examined. Putamen, caudate, intracranial volumes manually traced axial plane 3D reconstructed images. Striatal nuclei normalized to volume for statistical comparison. Disease status was assessed using Unified Rating Scale Hoehn Yahr scale....
Grey matter (GM) pathology in multiple sclerosis (MS) is associated with progressive long-term disability. Detection of GM abnormalities early MS may therefore be valuable understanding and predicting the course. However, structural MRI measures such as volume loss have shown only modest relapsing-remitting (RRMS). We investigated for evidence abnormality perfusion, consistent metabolic dysfunction, RRMS.25 RRMS patients ≤5 years disease duration 25 age-matched healthy controls underwent 3...
Emerging evidence suggests that Alzheimer's disease (AD) and Parkinson's dementia (PDD) share neurodegenerative mechanisms. We sought to directly compare cerebral perfusion in these two conditions using arterial spin labeling magnetic resonance imaging (ASL-MRI). In total, 17 AD, 20 PDD, 37 matched healthy controls completed ASL structural MRI, comprehensive neuropsychological testing. PDD was analyzed by whole-brain voxel-based analysis (to assess absolute blood flow), a priori specified...
The Movement Disorder Society Task Force (MDS-TF) has proposed diagnostic criteria for mild cognitive impairment in Parkinson's disease (PD-MCI). We hypothesized that the risk of dementia (PDD) varies across different cutoff schemes allowed. A longitudinal study followed 121 non-demented PD patients up to 4.5 years. In Part One, unique groups were identified as PD-MCI at baseline using MDS-TF requirement two impaired test scores, with both scores classified either (i) 2 s.d., (ii) 1.5 s.d....
The extent to which Alzheimer neuropathology, particularly the accumulation of misfolded beta-amyloid, contributes cognitive decline and dementia in Parkinson's disease (PD) is unresolved. Here, we used Florbetaben PET imaging test for any association between cerebral amyloid deposition impairment PD, a sample enriched cases with mild impairment. This cross-sectional study Movement Disorders Society level II criteria classify 115 participants PD as having normal cognition (PDN, n = 23),...
Studies with behavioural and neuropsychological tests have supported the developmental taxonomy theory of antisocial behaviour, which specifies abnormal brain development as a fundamental aspect life-course-persistent but no study has characterised features structure associated versus adolescence-limited trajectories, defined by prospective data. We aimed to determine whether behaviour is neurocognitive abnormalities testing hypothesis that it also abnormalities.
Abstract Work in animal and human neuroscience has identified neural regions forming a network involved the production of motivated, goal-directed behaviour. In particular, nucleus accumbens anterior cingulate cortex are recognized as key nodes underlying decisions whether to exert effort for reward, drive Previous work convincingly shown that this cognitive mechanism, known effort-based decision making, is altered people with Parkinson’s disease syndrome reduced behaviour—apathy. Building...
Stuttering affects approximately 1 in 100 adults and can result significant communication problems social anxiety. It most often occurs as a developmental disorder but also be caused by focal brain damage. These latter cases may lend unique insight into the regions causing stuttering. Here, we investigated neuroanatomical substrate of stuttering using three independent datasets: (i) case reports from published literature acquired neurogenic following stroke (n = 20, 14 males/six females,...
A robust understanding of the natural history apathy in Parkinson disease (PD) is foundational for developing effective clinical management tools. However, large longitudinal studies are lacking while literature inconsistent about even cross-sectional associations. We aimed to determine predictors development a cohort people with PD and its associations trajectories over time, using sophisticated Bayesian modeling techniques.