A5008211147- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- Mitochondrial Function and Pathology
- Botulinum Toxin and Related Neurological Disorders
- Neurological and metabolic disorders
- Olfactory and Sensory Function Studies
- Cerebral Palsy and Movement Disorders
- Functional Brain Connectivity Studies
- Occupational Health and Burnout
- Academic Research in Diverse Fields
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Physical Education and Gymnastics
- Transcranial Magnetic Stimulation Studies
- HIV/AIDS oral health manifestations
- Leprosy Research and Treatment
- Linguistics and Language Studies
- Cerebrovascular and genetic disorders
- Alzheimer's disease research and treatments
- Stroke Rehabilitation and Recovery
- Voice and Speech Disorders
- Balance, Gait, and Falls Prevention
- RNA regulation and disease
Universidade Estadual de Campinas (UNICAMP)
2015-2024
Brazilian Institute of Neuroscience and Neurotechnology
2024
Universitario Francisco de Asís
2024
Cognitive Neuroimaging Lab
2020
Hospital de Clínicas da Unicamp
2013-2019
Universidade Federal do Rio Grande do Norte
2018
Montreal Neurological Institute and Hospital
2017
McGill University
2017
Universidade Federal de Pernambuco
2011
Universidade Positivo
2011
ABSTRACT Background Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated. Objective Using a multicenter approach and harmonized analysis methods, we aimed shed light on stage‐specific profiles pathology, as suggested by in vivo neuroimaging. Methods Individual brain MRI clinical data from 2357 patients 1182 healthy controls were collected 19 sources. We analyzed regional cortical thickness, surface area, subcortical volume using...
ABSTRACT Although white matter damage may play a major role in the pathogenesis of spinocerebellar ataxia 3 (SCA3), available data rely exclusively upon macrostructural analyses. In this setting we designed study to investigate integrity. We evaluated 38 genetically‐confirmed SCA3 patients (mean age, 52.76 ± 12.70 years; 21 males) with clinical scales and brain magnetic resonance imaging (MRI) healthy subjects as control group 48.86 12.07 years, 20 male). All individuals underwent same...
Background and purpose Machado−Joseph disease ( MJD / SCA 3) is the most frequent spinocerebellar ataxia, characterized by brainstem, basal ganglia cerebellar damage. Few magnetic resonance imaging based studies have investigated damage in cerebral cortex. The objective was to determine whether patients with 3 cortex atrophy, identify regions more susceptible look for clinical neuropsychological correlates of such lesions. Methods Forty‐nine (mean age 47.7 ± 13.0 years, 27 men) 49 matched...
The progression of Parkinson's disease (PD) is associated with microstructural alterations in neural pathways, contributing to both motor and cognitive decline. However, conflicting findings have emerged due the use heterogeneous methods small studies. Here we performed a large diffusion MRI study PD, integrating data from 17 cohorts worldwide, identify stage-specific profiles white matter differences. Diffusion-weighted 1654 participants diagnosed PD (age: 20–89 years; 33% female) 885...
To estimate the clinical and demographics aspects that may contribute to cognitive impairment psychiatric symptoms in Parkinson's disease (PD).All patients answered a structured standardized questionnaire. Two movement disorders specialists performed following scale: Unified rating score (UPDRS), modified Hoehn Yahr staging, Schwab England Scale, SCOPA cognition (SCOPA-COG), SCOPA-Psychiatric complications (SCOPA-PC) Non-Motor Symptoms Scale (NMSS). We built generalized linear model assess...
Objectives: To assess white matter abnormalities in Parkinson's disease (PD). Methods: A hundred and thirty-two patients with PD (mean age 60.93 years; average duration 7.8 years) 137 healthy controls (HC; mean 57.8 underwent the same MRI protocol. Patients were assessed by clinical scales a complete neurological evaluation. We performed TBSS analysis to compare controls, we divided into early PD, moderate severe an ROI using tractography. Results: With found lower FA corpus callosum,...
Background: Parkinson's disease (PD) is progressive and affects different brain areas. Objectives: We aimed to describe structural functional changes in PD clinical stages. Methods: Sixty-six patients with (57.94±10.25 years) diagnosed according the UK Brain Bank criteria were included. performed a whole analysis using voxel-based morphometry (VBM-SPM 8 software), cortical thickness (CT) CIVET resting state-fMRI NIAK software compare controls. For VBM CT we classified subjects into three...
Parkinson's disease is the second most common neurodegenerative disease. Despite this, there are no robust biomarkers to predict progression, and understanding of mechanisms limited. We used Subtype Stage Inference algorithm characterize heterogeneity in terms spatiotemporal subtypes macroscopic atrophy detectable on T1-weighted MRI-a successful approach other diseases. trained model covariate-adjusted cortical thicknesses subcortical volumes from largest known MRI dataset disease, Enhancing...
Background Cognitive deficits in patients with asymptomatic carotid stenosis have been reported. The ultimate mechanism of cognitive remains unclear and might be related to subtle structural brain damage. Aims aim the present study was evaluate presence white grey matter abnormalities associated stenosis. Methods Twenty-five ≥70%/occlusion 25 healthy controls, matched for gender age, underwent 3 Tesla magnetic resonance imaging. Gray macrostructural were evaluated voxel-based morphometry...
Background: Huntington's disease (HD) is a progressive disorder characterized by motor, cognitive and psychiatric features. Cerebellar ataxia classically considered as uncommon in HD clinical spectrum. Objective: To determine the prevalence of cerebellar patients with HD, both early late stages HD. Methods: Seventy-two individuals eligible were assessed two trained doctors, applying Scale for Assessment Rating Ataxia (SARA) Brief (BARS) ataxia, Unified Disease (UHDRS) also, Barthel Index...
Background: Self-reported clinical worsening by people with Parkinson's disease (PD) during social distancing may be aggravated in Brazil, where the e/tele-health system is precarious. Objectives: This study aims to investigate self-reported changes motor and non-motor aspects PD living Brazil factors that might explain these changes. Methods: In this multicenter cross-sectional trial, 478 a diagnosis of idiopathic (mean age = 67, SD 9.5; 167 female) were recruited from 14 centers...
O escurecimento dentário intrínseco causado pela ingestão de tetraciclinas incomoda esteticamente o indivíduo.Estes antibióticos amplo espectro são usados no tratamento infecções como pneumonia, faringite, nas não complicadas do trato geniturinário, na cólera, diarreia, entre outras.É contraindicado em qualquer período gestação, lactação e para crianças abaixo oito anos idade, por produzir pigmentação dos dentes nos descendentes
Background: Several neuroimaging studies revealed widespread neurodegeneration in Parkinson's disease but only few considered the asymmetrical clinical presentation. Objective: To investigate gray matter (GM) atrophy Parkinson Disease considering side of motor symptom onset. Methods: Sixty patients (57.87± 10.27 years) diagnosed according to Brain Bank criteria, 26 with right-sided onset (RDO) and 34 left-sided (LDO), were compared 80 healthy controls (HC) (57.1± 9.47 years). T1-weighted...
Abstract Background The progression of Parkinson’s disease (PD) is associated with microstructural alterations in neural pathways, contributing to both motor and cognitive decline. However, conflicting findings have emerged due the use heterogeneous methods small studies, particularly regarding involvement white matter (WM) tracts. Here we performed largest diffusion MRI study PD date, integrating data from 17 cohorts worldwide, identify stage-specific profiles WM differences. Methods...
Dystonias are hyperkinetic movement disorders characterized by involuntary muscle contractions resulting in abnormal torsional movements and postures. Recent neuroimaging studies idiopathic craniocervical dystonia (CCD) have uncovered the involvement of multiple areas, including cortical ones. Our goal was to evaluate white matter (WM) microstructure subjects with CCD using diffusion tensor imaging (DTI) analysis.We compared 40 patients healthy controls. Patients were then divided into...
Dysphagia is a common symptom of Parkinson's disease (PD). A delay in laryngeal vestibule closure (LVC) and reduction tongue pressure, may affect swallowing safety increase the risk pulmonary aspiration.To verify relationship between pressure airway protection PD patients: (1) comparing measures physiological events pharyngeal phase controls (2) analysing association LVC group.Twenty-three patients with idiopathic (64.9 years) 24 healthy (64.1 participated this study. All participants...
Abstract Background Brain structure abnormalities throughout the course of Parkinson’s disease (PD) have yet to be fully elucidated. Inconsistent findings across studies may partly due small sample sizes and heterogeneous analysis methods. Using a multicenter approach harmonized methods, we aimed overcome these limitations shed light on stage-specific profiles PD pathology as suggested by in vivo neuroimaging. Methods Individual brain MRI clinical data from 2,367 patients 1,183 healthy...
<strong>Background:</strong> Dystonias are hyperkinetic movement disorders characterized by involuntary muscle contractions resulting in abnormal torsional movements and postures. Recent neuroimaging studies idiopathic craniocervical dystonia (CCD) have uncovered the involvement of multiple areas, including cortical ones. Our goal was to evaluate white matter (WM) microstructure subjects with CCD using diffusion tensor imaging (DTI) analysis. <strong>Methods:</strong> We compared 40 patients...
Este estudo tem o intuito de mensurar conhecimento e experiências individuais dos entrevistados sobre tema Manifestações neurofisiológicas nos distúrbios ansiedade no ambiente acadêmico da Unifoa, bem como identificar os indivíduos acometidos pelos transtornos ansiedade, sintomas sofridos por fim sugerir ferramentas oferecidas pela instituição, CAIP (Centro aperfeiçoamento inovação pedagógica) para acolhimento oitiva com psicólogo instituição. Para tanto, foi utilizado método coleta dados um...
Este estudo tem o intuito de mensurar conhecimento e experiências individuais dos entrevistados sobre tema Manifestações neurofisiológicas nos distúrbios ansiedade no ambiente acadêmico da Unifoa, bem como identificar os indivíduos acometidos pelos transtornos ansiedade, sintomas sofridos por fim sugerir ferramentas oferecidas pela instituição, CAIP (Centro aperfeiçoamento inovação pedagógica) para acolhimento oitiva com psicólogo instituição. Para tanto, foi utilizado método coleta dados um...
Abstract Alterations in subcortical brain regions are linked to motor and non-motor symptoms Parkinson’s disease (PD). However, associations between clinical expression regional morphological abnormalities of the basal ganglia, thalamus, amygdala hippocampus not well established. We analyzed 3D T1-weighted MRI data from 2525 individuals with PD 1326 controls 22 global sources ENIGMA-PD consortium. investigated effects using mass univariate multivariate models on medial thickness 27,120...
To assess the effect of Parkinson's Disease on in-vivo cortical thickness measures in a large multicenter study.