Stefan N. Willich

ORCID: 0009-0006-1270-2597
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About
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Research Areas
  • Complementary and Alternative Medicine Studies
  • Acupuncture Treatment Research Studies
  • Health and Medical Studies
  • Health Systems, Economic Evaluations, Quality of Life
  • Pain Management and Placebo Effect
  • Allergic Rhinitis and Sensitization
  • Gastroesophageal reflux and treatments
  • Asthma and respiratory diseases
  • Atrial Fibrillation Management and Outcomes
  • Herbal Medicine Research Studies
  • Helicobacter pylori-related gastroenterology studies
  • Eosinophilic Esophagitis
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Blood Pressure and Hypertension Studies
  • Cardiac Health and Mental Health
  • Heart Failure Treatment and Management
  • Dermatology and Skin Diseases
  • Health Promotion and Cardiovascular Prevention
  • Acute Myocardial Infarction Research
  • Climate Change and Health Impacts
  • Acute Ischemic Stroke Management
  • Psychosomatic Disorders and Their Treatments
  • Cardiac pacing and defibrillation studies
  • Venous Thromboembolism Diagnosis and Management
  • Obesity, Physical Activity, Diet

Charité - Universitätsmedizin Berlin
2016-2025

Freie Universität Berlin
1993-2025

Humboldt-Universität zu Berlin
2006-2025

Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2007-2023

Berlin Heart (Germany)
2020

Bernstein Center for Computational Neuroscience Berlin
2019

Robert Koch Institute
2016

German Centre for Cardiovascular Research
2016

Universität Hamburg
2015

Zimmer Biomet (Germany)
2015

Acupuncture is widely used to prevent migraine attacks, but the available evidence of its benefit scarce.To investigate effectiveness acupuncture compared with sham and no in patients migraine.Three-group, randomized, controlled trial (April 2002-January 2003) involving 302 (88% women), mean (SD) age 43 (11) years, headaches, based on International Headache Society criteria. Patients were treated at 18 outpatient centers Germany.Acupuncture, acupuncture, or waiting list control. administered...

10.1001/jama.293.17.2118 article EN JAMA 2005-05-03

In a pooled analysis of four randomized controlled trials acupuncture in patients with migraine, tension-type headache, chronic low back pain, and osteoarthritis the knee we investigated influence expectations on clinical outcome. The 864 included received either 12 sessions or minimal (i.e. sham) (superficial needling non-acupuncture points) over an 8 week period. Patients were asked at baseline whether they considered to be effective therapy general what personally expected from treatment....

10.1016/j.pain.2006.12.006 article EN Pain 2007-01-26

Background: To evaluate the safety of acupuncture in a large number patients receiving conventional health care and, based on these results, to develop new medical consent form for acupuncture. Methods: The prospective observational study included who received treatment chronic osteoarthritis pain knee or hip, low back pain, neck headache, allergic rhinitis, asthma, dysmenorrhoea. After treatment, all documented adverse events associated with (defined as effects). Patients reported need due...

10.1159/000209315 article EN Complementary Medicine Research 2009-01-01

<h3>Background:</h3> Acupuncture is widely used by patients with low back pain, although its effectiveness unclear. We investigated the efficacy of acupuncture compared minimal and no in chronic pain. <h3>Methods:</h3> Patients were randomized to treatment acupuncture, (superficial needling at nonacupuncture points), or a waiting list control. administered specialized physicians 30 outpatient centers, consisted 12 sessions per patient over 8 weeks. completed standardized questionnaires...

10.1001/archinte.166.4.450 article EN Archives of Internal Medicine 2006-02-27

Neuroendocrine tumors (NETs) of the gastroenteropancreatic (GEP) system comprise a rare but challenging group malignant neoplasms and occur at virtually any site GEP system. In 2006, new TNM classification was proposed for staging grading upper NETs.The prognostic relevance analyzed retrospectively in 202 patients from referral center with histologically proven foregut NET. Patients were classified according to previous systems classification. Survival data acquired statistical analyses...

10.1002/cncr.23549 article EN Cancer 2008-05-27

Objective To investigate the effectiveness of acupuncture compared with minimal and no in patients tension-type headache. Design Three armed randomised controlled multicentre trial. Setting 28 outpatient centres Germany. Participants 270 (74% women, mean age 43 (SD 13) years) episodic or chronic Interventions Acupuncture, (superficial needling at non-acupuncture points), waiting list control. Acupuncture were administered by specialised physicians consisted 12 sessions per patient over eight...

10.1136/bmj.38512.405440.8f article EN BMJ 2005-07-29

The time of acute myocardial infarction was determined in all 1,741 patients the ISAM (Intravenous Streptokinase Acute Myocardial Infarction) Study, based on onset clinical symptoms and evaluation plasma CK-MB enzyme time-activity curves. incidence markedly increased between 6:00 AM 12:00 noon compared with other times day (p less than 0.001). occurred 3.8 more frequently 8:00 9:00 (hour maximum incidence) midnight 1:00 minimum incidence). Time enzymatic methods correlated well (r = 0.95)....

10.1161/01.cir.80.4.853 article EN Circulation 1989-10-01

Computed tomography (CT) allows estimation of coronary artery calcium (CAC) progression. We evaluated several progression algorithms in our unselected, population-based cohort for risk prediction and cardiovascular events.In 3281 participants (45-74 years age), free from disease until the second visit, factors, CTs at baseline (b) after a mean 5.1 (5y) were measured. Hard events, total events including revascularization, as well, recorded during follow-up time 7.8±2.2 CT. The added...

10.1161/circulationaha.116.027034 article EN cc-by-nc-nd Circulation 2017-11-15

Abstract Perfluoroalkyl substances (PFASs) are a complex group of man-made chemicals with high stability and mobility leading to ubiquitous environmental contamination accumulation in the food chain. In human serum/plasma samples, perfluorooctanoic acid (PFOA) perfluorooctane sulfonate (PFOS) lead compounds. They immunotoxic experimental animals, epidemiological studies provided evidence diminished production vaccine antibodies young children. However, information on children first year age...

10.1007/s00204-020-02715-4 article EN cc-by Archives of Toxicology 2020-03-29

Several studies have reported circadian and seasonal variations in acute cardiovascular disease. In addition, a weekly variation has been observed myocardial infarction. The aim of our study was to determine the weekly, sudden death utilizing population-based data.We analysed emergency medical system data Berlin (West) from 1987-1991 with respect all consecutive deaths subjects >18 years (n=24 061). There marked death, minimum between 0 6 h maximum 12 (P<0.0001) for every day week. A events...

10.1053/euhj.1999.1739 article EN European Heart Journal 2000-02-15

The frequencies of onset myocardial infarction and sudden cardiac death are increased between 6 AM 12 noon. Platelet aggregability, which may play a role in the cause these disorders, has been observed to increase after normal morning activities awakening, arising, ambulating. To determine activity or responsible for this aggregability increase, we measured platelet aggregation 16 subjects on control day delayed arising (i.e., remained supine until 12:30 PM) were divided into three isolated...

10.1161/01.cir.78.1.35 article EN Circulation 1988-07-01

Gastro-oesophageal reflux disease (GERD) can be associated with a variety of extra-oesophageal disorders (EED) such as chronic cough, asthma, laryngeal disorder or chest pain. The aim the study was to estimate and compare prevalence EED in population symptomatic GERD presenting either erosive (ERD) non-erosive (NERD).Baseline data were collected from prospective, multicentre, open cohort (ProGERD) which patients will followed for 5 years after initial treatment esomeprazole. Within framework...

10.1046/j.1365-2036.2003.01606.x article EN Alimentary Pharmacology & Therapeutics 2003-06-01

Summary Aims : To determine the impact of gastro‐oesophageal reflux disease (GERD) on quality life, to assess changes in life during treatment with esomeprazole and define factors that can predict these changes. Methods Patients GERD ( n = 6215) were included a prospective cohort study (ProGERD). All patients underwent endoscopy received esomeprazole. At baseline after 2 weeks treatment, symptoms assessed. Factors influenced determined by multiple regression analyses. Results baseline, was...

10.1046/j.1365-2036.2003.01770.x article EN Alimentary Pharmacology & Therapeutics 2003-09-30

Although the symptoms of gastro-oesophageal reflux disease are common in general adult population, aetiology is still largely unknown. Lifestyle factors such as diet, body mass index, and smoking have been frequently suggested possible risk factors.In present study, we investigated relationship between various lifestyle symptoms.A total 7124 subjects were interviewed part German National Health Interview Examination Survey, a representative sample population. We examined variety factors,...

10.1111/j.1365-2036.2006.02727.x article EN Alimentary Pharmacology & Therapeutics 2005-12-13
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