Daniela Rodriguez-Manrique
A5089726481- Obsessive-Compulsive Spectrum Disorders
- Functional Brain Connectivity Studies
- Autism Spectrum Disorder Research
- Mental Health Research Topics
- Neuroscience and Neuropharmacology Research
- Botulinum Toxin and Related Neurological Disorders
- Olfactory and Sensory Function Studies
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Transcranial Magnetic Stimulation Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Attention Deficit Hyperactivity Disorder
- Action Observation and Synchronization
- Neural dynamics and brain function
- Eating Disorders and Behaviors
Technical University of Munich
2021-2025
Klinikum rechts der Isar
2021-2025
Ludwig-Maximilians-Universität München
2021-2025
Janssen (Belgium)
2020
Abstract Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, majority studies have focused only predefined regions or networks rather than throughout entire brain. Here, we investigated differences resting-state between OCD patients and healthy controls (HC) using mega-analysis data from 1024 1028 HC 28 independent samples ENIGMA-OCD consortium. We assessed group...
Alzheimer’s disease (AD) is characterized by neuronal loss and impaired synaptic transmission, ultimately leading to cognitive deficits. Early in the disease, olfactory track seems most sensitive tauopathy, while plasticity studies focused on hippocampal circuits. Functional network connectivity (FC) long-term potentiation (LTP), considered as substrate of learning memory, were longitudinally assessed mice P301S model tauopathy following course (time location) progressively neurodegenerative...
Obsessive-compulsive disorder (OCD) is associated with altered brain function related to processing of negative emotions. To investigate neural correlates valence in OCD, we pooled fMRI data 633 individuals OCD and 453 healthy controls from 16 studies using different negatively-valenced tasks across the ENIGMA-OCD Working-Group.
Changes in grey matter volume have frequently been reported patients with obsessive-compulsive disorder (OCD). Most studies performed whole brain or region-of-interest based analyses whereas on structural covariance networks has barely investigated up to now. Therefore, the present study within a sample of 228 participants (n = 117 OCD patients, n 111 healthy controls). First, an independent component analysis (ICA) was all subjects' preprocessed T1 images derive covariance-dependent...
Abstract White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and predominance single-site studies, generalizability OCD classification based on white estimates remains unclear. Here, we tested accuracy using largest DTI dataset date, involving 1,336 adult participants (690 patients 646 healthy controls) 317 pediatric (175 142 from 18 international...
The aging process eventually cause a breakdown in critical synaptic plasticity and connectivity leading to deficits memory function. olfactory bulb (OB) the hippocampus, both regions of brain considered for processing odors spatial memory, are commonly affected by aging. Using an aged wild-type C57B/6 mouse model, we sought define effects on hippocampal integrity cortical circuits. Specifically, measured long-term potentiation high-frequency stimulation (HFS-LTP) at Shaffer-Collateral CA1...
<title>Abstract</title> Inhibition deficits constitute a core characteristic of obsessive-compulsive disorder (OCD). There is evidence in healthy individuals that transcranial direct current stimulation (tDCS) the pre-supplementary motor area (pre-SMA) leads to significantly improved inhibition performance. Against this background we investigated effects pre-SMA tDCS on performance and underlying neural correlates patients with OCD. Using double-blind, randomized, sham-controlled, cross-over...
<title>Abstract</title> Resting state fMRI (rs-fMRI) Studies have shown that patients with obsessive-compulsive disorder (OCD) exhibit alterations in cortical excitability and neuronal synchronisation. Amplitude of low frequency fluctuations (ALFF) is a measure used assess the intensity oscillations (LFOs) between 0.01-0.1Hz, which are believed to reflect neural activity. Amplitudes these LFOs particular interest as they range depending on brain area task. However, ALFF requires...
Motor conflicts arise when we need to quickly overwrite prepotent behavior. It has been proposed that affective stimuli modulate the neural processing of motor conflicts. However, previous studies have come inconsistent conclusions regarding impact information on conflict processing. We employed functional magnetic resonance imaging during a Go/Change-Go task, where were either evoked by neutral or emotionally negative stimuli. Dynamic causal modeling was used investigate how...
Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, majority studies have focused only predefined regions or networks rather than throughout entire brain. Here, we investigated differences resting-state between OCD patients and healthy controls (HC) using mega-analysis data from 1,024 1,028 HC 28 independent samples ENIGMA-OCD consortium. We assessed group whole-brain at...
ABSTRACT Objective Higher thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and clinical-level symptoms within the general population. Particular subregions may drive these differences. The ENIGMA-OCD working group conducted mega- meta-analyses to study subregional OCD across lifespan. Method Structural T 1 -weighted brain magnetic resonance imaging (MRI) scans from 2,649 patients 2,774 healthy controls 29 sites (50 datasets) were processed using FreeSurfer...