A5073961229- Obsessive-Compulsive Spectrum Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Eating Disorders and Behaviors
- Treatment of Major Depression
- Body Image and Dysmorphia Studies
- Mental Health Research Topics
- Psychosomatic Disorders and Their Treatments
- Schizophrenia research and treatment
Amsterdam Neuroscience
2023-2024
Amsterdam University Medical Centers
2023-2024
Vrije Universiteit Amsterdam
2023-2024
GGz centraal
2023-2024
Predicting treatment efficacy in psychiatric disorders remains challenging, despite the availability of effective interventions. Previous studies suggest a link between brain network topology and individual disorders, but cross-disorder investigations are lacking. We analyzed pre-treatment MRI data from 177 individuals (113 females) with either obsessive-compulsive disorder (OCD) or post-traumatic stress comorbid personality (PTSD) that received different non-pharmacological treatments....
Poor insight in obsessive-compulsive disorder (OCD) is associated with higher symptom severity, more comorbidities, and worse response to treatment. This study aimed elucidate underlying mechanisms of poor OCD by exploring its neurobiological correlates. Using a provocation task during functional magnetic resonance imaging, we compared brain activation patients (n = 19; 14 female, 5 male), good/fair 63; 31 32 healthy control participants 42; 22 20 male) using Bayesian region-of-interest...
Although cognitive behavioral therapy (CBT) effectively treats obsessive-compulsive disorder (OCD), many patients refuse CBT or drop out prematurely, partly because of anxiety regarding exposure and response prevention (ERP) exercises. Inference-based (I-CBT) focuses on correcting distorted inferential thinking patterns, enhancing reality-based reasoning, addressing obsessional doubt by targeting underlying dysfunctional without incorporating an ERP component. We hypothesized that I-CBT...
Obsessive-compulsive disorder (OCD) is associated with altered brain function related to processing of negative emotions. To investigate neural correlates valence in OCD, we pooled fMRI data 633 individuals OCD and 453 healthy controls from 16 studies using different negatively-valenced tasks across the ENIGMA-OCD Working-Group.