A5023546845- Attention Deficit Hyperactivity Disorder
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Neurotransmitter Receptor Influence on Behavior
- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Health, Environment, Cognitive Aging
- Treatment of Major Depression
- Substance Abuse Treatment and Outcomes
- Pharmaceutical studies and practices
- Youth Substance Use and School Attendance
- Prenatal Substance Exposure Effects
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Neuroscience and Neuropharmacology Research
- Birth, Development, and Health
- Neuroethics, Human Enhancement, Biomedical Innovations
- Eating Disorders and Behaviors
- Neuroscience of respiration and sleep
- Child Nutrition and Feeding Issues
- Maternal Mental Health During Pregnancy and Postpartum
Icahn School of Medicine at Mount Sinai
2016-2025
Community Living
2025
Mount Sinai Medical Center
2024
Issues Research
2019
The University of Melbourne
2019
Mount Sinai Health System
2019
Radboud University Nijmegen
2019
St. Luke's-Roosevelt Hospital Center
2018
UCLA Health
2017
American Academy of Child and Adolescent Psychiatry
2017
The role of the thalamus in genesis attention deficit hyperactivity disorder (ADHD) remains poorly understood. authors used anatomical MRI to examine morphology youths with ADHD and healthy comparison youths.The examined 46 59 8-18 years age a cross-sectional case-control study. Conventional volumes measures surface served as main outcome measures.A mixed-effects model comparing whole thalamic revealed no significant differences between groups. Maps significantly smaller regional bilaterally...
Context: Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent and impairing psychiatric that affects both children adults.There are Food Drug Administration-approved stimulant nonstimulant medications for treating ADHD; however, little known about the mechanisms by which these different treatments exert their therapeutic effects.Objective: To contrast changes in brain activation related to symptomatic improvement with use of methylphenidate hydrochloride vs atomoxetine...
Objective Disturbances in the basal ganglia portions of cortico-striato-thalamo-cortical circuits likely contribute to symptoms attention deficit hyperactivity disorder (ADHD). The authors examined morphologic features nuclei (caudate, putamen, and globus pallidus) children with ADHD. Method A total 104 individuals (combined-type ADHD patients: N=47; healthy comparison subjects: N=57), aged 7 18 years, were a cross-sectional case-control study using anatomical magnetic resonance imaging....
No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures cortical thickness, surface area subcortical volume tested classification performance cross-validation. Classification vs. complete sample different classifiers cross-validation strategies was...
Background: Accumulating evidence suggests that sleep disordered breathing (SDB) is under-recognized in youth and adults with ADHD. SDB may contribute to exacerbating pre-existing ADHD symptoms play a role the development of cognitive deficits mimic symptoms. Method: We conducted focused review publications on cross-prevalence, overlapping clinical neurobiological characteristics possible mechanisms linking Results: Exiting studies suggest co-occurrence as high 50%, frequent overlap such...
Context:The basal ganglia and thalamus together connect in parallel closed-loop circuits with the cortex.Previous imaging studies have shown modifications of cortical targets individuals Tourette syndrome (TS), but less is known regarding role TS pathogenesis.Objective: To study morphological features children adults TS.Design: A cross-sectional, case-control using anatomical magnetic resonance imaging.Setting: University research center. Participants:The 283 participants included 149 134...
Objective: This study compared the methylphenidate (MPH) dose–response profiles of children with Predominantly Inattentive (PI) and Combined (CB) subtypes attention-deficit/hyperactivity disorder (ADHD). It is first such to enroll a sample comprised exclusively children, all but one whom had no prior exposure ADHD medications. Method: The design was double-blind crossover 1-week exposures placebo low, medium, high, fixed, three times daily (t.i.d.) dosage regimens immediate-release MPH,...
This review summarizes the last decade of work by ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance over 1,400 scientists across 43 countries, studying human brain in health and disease. Building on large-scale genetic studies that discovered first robustly replicated loci associated with metrics, has diversified into 50 working groups (WGs), pooling worldwide data expertise to answer fundamental questions neuroscience, psychiatry, neurology,...
The long-term effects of blast exposure are a major health concern for combat veterans returning from the recent conflicts in Iraq and Afghanistan. We used an optimized diffusion tensor imaging tractography algorithm to assess white matter (WM) fractional anisotropy (FA) blast-exposed Afghanistan (n = 40) scanned on average 3.7 years after deployment/trauma exposure. Veterans diagnosed with blast-related mild traumatic brain injury (mTBI) were compared but no TBI diagnosis. Blast was...
Abstract Reinforcement learning studies propose that decision-making is guided by a tradeoff between computationally cheaper model-free (habitual) control and costly model-based (goal-directed) control. Greater typically used under highly rewarding conditions to minimize risk maximize gain. Although prior have shown impairments in sensitivity reward value individuals with frequent alcohol use, it unclear how these arbitrate based on the magnitude of incentives. In this study, 81 (47 Alcohol...
The very first time I met was Jim 32 years ago at Community Living Opportunities (CLO). remember that meeting and the unmistakable realization in presence of an exceptional man who radiated intelligence, kindness, compassion. In next decades, became close, forging a relationship transcended our professional encounters evolved into enriching unshakable friendship. This friendship gifted me with invaluable wealth. A wealth knowledge. Just like countless others, learned so much about from Jim....