A5070722308- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Birth, Development, and Health
- Infant Development and Preterm Care
- Epigenetics and DNA Methylation
- Child Abuse and Trauma
- COVID-19 Impact on Reproduction
- Neonatal and fetal brain pathology
- Maternal and Perinatal Health Interventions
- Stress Responses and Cortisol
- Cancer Genomics and Diagnostics
- Family Support in Illness
- Neuroendocrine regulation and behavior
- Infant Health and Development
- Obesity, Physical Activity, Diet
- Gestational Diabetes Research and Management
- Pregnancy and Medication Impact
- Breastfeeding Practices and Influences
- Child Nutrition and Feeding Issues
- Cancer-related gene regulation
- Prenatal Substance Exposure Effects
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Neonatal Respiratory Health Research
- COVID-19 and Mental Health
Michigan State University
2025
Columbia University
2016-2025
New York State Psychiatric Institute
2016-2025
Columbia University Irving Medical Center
2016-2025
Cohort (United Kingdom)
2024-2025
Columbia College
2015-2024
Royal College of Physicians
2021-2024
New York Psychoanalytic Society and Institute
2015-2024
University of South Dakota
2024
Avera Health
2024
Maternal exposure to stress during pregnancy is associated with significant alterations in offspring neurodevelopment and elevated maternal glucocorticoids likely play a central role mediating these effects. Placental 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2) buffers the impact of glucocorticoid by converting cortisol/corticosterone into inactive metabolites. However, previous studies indicate that adversity prenatal period can lead down-regulation this enzyme. In current study, we...
As New York City became an international epicenter of the novel coronavirus disease 2019 (COVID-19) pandemic, telehealth was rapidly integrated into prenatal care at Columbia University Irving Medical Center, academic hospital system in Manhattan. Goals implementation were to consolidate in-person screening, surveillance, and examinations fewer visits while maintaining patient access ongoing antenatal subspecialty consultations via virtual visits. The rationale for this change minimize...
Objective: Increased risk of psychopathology is observed in children exposed to maternal prenatal distress, and elevated cortisol epigenetic regulation placental glucocorticoid-pathway genes are potential mechanisms. The authors examined distress salivary relation fetal movement heart rate (“coupling”) DNA methylation three glucocorticoid pathway genes—HSD11B2, NR3C1, FKBP5—in term placentas. Method: Mood questionnaires were collected from 61 women between 24–27 gestational weeks, assessment...
Significance Despite decades of prenatal programming research showing that “the womb may be more important than the home” with respect to offspring health outcomes, no studies which we are aware have considered multiple indicators maternal stress identify types most influence developing offspring. This study’s key contributions include use a data-driven procedure specify stress—psychological and subclinical physical indicators—that predict outcomes including sex at birth, risk preterm fetal...
Associations between in utero exposure to maternal SARS-CoV-2 infection and neurodevelopment are speculated, but currently unknown.To examine the associations during pregnancy, being born COVID-19 pandemic regardless of status, at age 6 months.A cohort infants exposed pregnancy unexposed controls was enrolled Mother Baby Outcomes Initiative Columbia University Irving Medical Center New York City. All women who delivered with a were approached. Women approached based on similar gestational...
Prenatal maternal immune activation (MIA) is associated with altered brain development and risk of psychiatric disorders in offspring. Translational human studies MIA are few number. Alterations the salience network have been implicated pathogenesis same MIA. If pathogenic, then abnormalities should be detectable neonates immediately after birth. We tested hypothesis that third trimester adolescent women who at for high stress inflammation strength functional connectivity their neonate....
BackgroundChildhood maltreatment is associated with adverse health outcomes and this risk can be transmitted to the next generation. We aimed investigate association between exposure maternal childhood common physical mental problems, neurodevelopmental disorders, related comorbidity patterns in offspring.Methods.We conducted a retrospective cohort study using data from Environmental influences on Child Health Outcomes (ECHO) Program, which was launched influence of early life exposures...
This study examined the effect of an acute maternal stress response and anxiety on fetal heart rate. Seventeen healthy, 3rd-trimester pregnant women (mean age = 26 +/- 6 years) were instrumented for continuous electrocardiography, blood pressure (BP), respiration, rate (HR). Subjects completed state subscale State Trait Personality Inventory (STPI), then rested quietly in a semirecumbent position 5-min baseline period, followed by either arithmetic or Stroop color-word task. Over entire...
Abstract Prenatal exposure to maternal depression is common and puts offspring at risk for developing a range of neuropsychiatric disorders. Despite its prevalence adverse associations, neurobiological processes by which prenatal (PMD) confers remain poorly understood. Maternal mood fetal behavior were assessed between 34 37 gestational weeks. Using resting-state functional magnetic resonance imaging (fMRI) diffusion MRI, we examined structural connectivity within amygdala–prefrontal...
<h3>Importance</h3> Selective serotonin reuptake inhibitor (SSRI) use among pregnant women is increasing, yet the association between prenatal SSRI exposure and fetal neurodevelopment poorly understood. Animal studies show that perinatal alters limbic circuitry produces anxiety depressive-like behaviors after adolescence, but literature on in humans limited mixed. <h3>Objective</h3> To examine associations brain development using structural diffusion magnetic resonance imaging (MRI)....
Using a high-throughput mitochondrial phenotyping platform to quantify multiple features among molecularly defined immune cell subtypes, we the natural variation in DNA copy number (mtDNAcn), citrate synthase, and respiratory chain enzymatic activities human neutrophils, monocytes, B cells, naïve memory T lymphocyte subtypes. In mixed peripheral blood mononuclear cells (PBMCs) from same individuals, show what extent measures are confounded by both type distributions contaminating platelets....
Abstract The impact of COVID-19-related stress on perinatal women is heightened public health concern given the established intergenerational maternal stress-exposure infants and fetuses. There urgent need to characterize coping styles associated with adverse psychosocial outcomes in during COVID-19 pandemic help mitigate potential for lasting sequelae both mothers infants. This study uses a data-driven approach identify patterns behavioral strategies that associate distress large...
Importance Associations between prenatal SARS-CoV-2 exposure and neurodevelopmental outcomes have substantial public health relevance. A previous study found no association infection parent-reported infant outcomes, but standardized observational assessments are needed to confirm this finding. Objective To assess whether mild or asymptomatic maternal vs during pregnancy is associated with differences at ages 5 11 months. Design, Setting, Participants This cohort included infants of mothers...