Margaret H. Kyle

ORCID: 0000-0003-0771-827X
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About
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Research Areas
  • COVID-19 Impact on Reproduction
  • Maternal Mental Health During Pregnancy and Postpartum
  • COVID-19 and Mental Health
  • Sleep and related disorders
  • Neonatal Respiratory Health Research
  • Breastfeeding Practices and Influences
  • Neuroendocrine regulation and behavior
  • Global Maternal and Child Health
  • Stress Responses and Cortisol
  • Child and Adolescent Psychosocial and Emotional Development
  • Food Security and Health in Diverse Populations
  • Olfactory and Sensory Function Studies
  • Ectopic Pregnancy Diagnosis and Management
  • Neuroscience of respiration and sleep
  • Maternal and Perinatal Health Interventions
  • Child Development and Digital Technology
  • Pregnancy-related medical research
  • Hearing, Cochlea, Tinnitus, Genetics
  • Child Abuse and Trauma
  • Infant Development and Preterm Care
  • Family Support in Illness
  • Pregnancy and Medication Impact
  • Autism Spectrum Disorder Research
  • Neonatal and fetal brain pathology

New York Hospital Queens
2025

Columbia University
2022-2025

NewYork–Presbyterian Hospital
2025

Columbia University Irving Medical Center
2020-2025

Pediatrics and Genetics
2022

Morgan Stanley Children's Hospital
2022

<h3>Importance</h3> Limited data on vertical and perinatal transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) health outcomes neonates born to mothers with symptomatic or asymptomatic disease 2019 (COVID-19) are available. Studies needed inform evidence-based infection prevention control (IP&amp;C) policies. <h3>Objective</h3> To describe the SARS-CoV-2 IP&amp;C practices associated these outcomes. <h3>Design, Setting, Participants</h3> This retrospective cohort...

10.1001/jamapediatrics.2020.4298 article EN JAMA Pediatrics 2020-10-12

Associations between in utero exposure to maternal SARS-CoV-2 infection and neurodevelopment are speculated, but currently unknown.To examine the associations during pregnancy, being born COVID-19 pandemic regardless of status, at age 6 months.A cohort infants exposed pregnancy unexposed controls was enrolled Mother Baby Outcomes Initiative Columbia University Irving Medical Center New York City. All women who delivered with a were approached. Women approached based on similar gestational...

10.1001/jamapediatrics.2021.5563 article EN JAMA Pediatrics 2022-01-04

Importance Associations between prenatal SARS-CoV-2 exposure and neurodevelopmental outcomes have substantial public health relevance. A previous study found no association infection parent-reported infant outcomes, but standardized observational assessments are needed to confirm this finding. Objective To assess whether mild or asymptomatic maternal vs during pregnancy is associated with differences at ages 5 11 months. Design, Setting, Participants This cohort included infants of mothers...

10.1001/jamanetworkopen.2023.7396 article EN cc-by-nc-nd JAMA Network Open 2023-04-10

The COVID-19 pandemic has intensified economic hardships, with potential negative impacts on food insecurity and infant feeding beliefs practices. relationship between practices during the is not yet fully understood. Neither how these relationships changed over course of waves pandemic. We examined in a cohort infants born various New York City (NYC). conducted cross-sectional analysis enrolled from birth into Mother-Baby Outcomes (COMBO) study March 2020 to May 2024. measured prior 30 days...

10.1101/2025.02.07.25321881 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2025-02-10

Abstract Olfactory dysfunction resulting from COVID-19 has imparted a lasting impact on olfaction among the general public, including pregnant women contracting SARS-CoV-2 infection. While olfactory can physical, mental, and psychosocial well-being, there been little research during pregnancy postpartum, nor of infection while pregnant. Therefore, primary study aims are to evaluate in postpartum period determine antecedent We recruited two cohorts women, those with history before or (COVID...

10.1093/chemse/bjaf009 article EN Chemical Senses 2025-04-22

Importance Stress and viral illness during pregnancy are associated with neurodevelopmental conditions in offspring. Autism screening positivity for children born the pandemic remains unknown. Objective To examine associations between prenatal exposure to milieu maternal SARS-CoV-2 infection rates of positive Modified Checklist Toddlers, Revised (M-CHAT-R) screenings. Design, Setting, Participants Data this cohort study were drawn from COVID-19 Mother Baby Outcomes (COMBO) Initiative....

10.1001/jamanetworkopen.2024.35005 article EN cc-by-nc-nd JAMA Network Open 2024-09-23

Abstract Objectives To investigate the role of prenatal maternal SARS-CoV-2 infection and delivery during COVID-19 pandemic on breastfeeding practices through 6 months postpartum. Study design A cohort mother-infant dyads who delivered at a large medical center in New York City had either documented history infection, no or February 2020 prior to were invited participate Mother Baby Outcomes (COMBO) Initiative. These three groups mothers completed surveys about their 1, 2, 4, and/or...

10.1101/2024.07.14.24309868 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2024-07-15

The intrauterine environment strongly influences development. Neurodevelopmental effects of in utero exposure to maternal SARS-CoV-2 infection are widely speculated but currently unknown. COVID-19 Mother Baby Outcomes (COMBO) initiative was established at Columbia University Irving Medical Center (CUIMC) New York City prospectively study the health and wellbeing infants with without infection. We report findings on 6-month neurodevelopmental outcomes using parental-report Ages &amp; Stages...

10.1101/2021.07.12.21260365 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2021-07-15

ABSTRACT Study Objectives To quantify the association between race/ethnicity and maternal infant self-reported sleep health at 4 months, exploring role of depression, stress symptoms trauma related to COVID-19 pandemic as potential mediators. Methods Participants were recruited part Mother Baby Outcomes (COMBO) cohort Columbia University (N=71 non-Hispanic White, N=14 African American (AA), N=113 Hispanic, N=40 other/declined). Data on collected months postpartum. A subset 149 women also...

10.1101/2021.03.22.21254093 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2021-03-26

Abstract As research efforts in the field of pediatrics are oriented toward a better understanding synergistic relationship between different facets early relational health (ERH) and child development wellbeing, it is essential to focus on quality instruments available for measuring components ERH. This study investigates measurement characteristics widely used parent/caregiver-reported measure bonding, Postpartum Bonding Questionnaire (PBQ), US-based sample (n=610) English-speaking...

10.1101/2023.04.09.23288334 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2023-04-17

Objective Given the prevalence of neonatal hearing loss (HL) associated with intrauterine viral exposures, goal this study is to provide information on HL in context COVID‐19 pandemic. Methods Data were drawn from Mother Baby Outcomes (COMBO) Initiative. 1007 participants completed newborn screen as part routine clinical care (COMBO‐EHR cohort) and 555 National Survey Children's Health (NSCH) at 2 and/or 3 years age for research purposes (COMBO‐RSCH cohort). Maternal SARS‐CoV‐2 infection...

10.1002/lary.31739 article EN The Laryngoscope 2024-09-04

During the COVID-19 pandemic, birthing parents were identified as a high-risk group with greater vulnerability to harms associated SARS-CoV-2. This led necessary changes in perinatal health policies but also experiences of maternal isolation and loneliness, both hospital settings, due infection mitigation procedures, once home, social distancing. In this study, we qualitatively explored postpartum New York City during early days pandemic when lockdowns effect practices rapidly changing....

10.1111/jmwh.13695 article EN Journal of Midwifery & Women s Health 2024-11-09

Abstract Maternal stress and viral illness during pregnancy are associated with neurodevelopmental conditions in offspring. Children born the COVID-19 pandemic, including those exposed prenatally to maternal SARS-CoV-2 infections, reaching developmental age for assessment of risk conditions. We examined associations between birth prenatal exposure infection, rates positive screenings on Modified Checklist Autism Toddlers-Revised (M-CHAT-R). Data were drawn from Mother Baby Outcomes (COMBO)...

10.1101/2024.02.20.24302892 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2024-02-22

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 600 million people worldwide, including millions of pregnant women. While newborns exposed to other viruses in utero are sometimes at high risk for vertical transmission, a substantial body literature since early 2020 demonstrated that transmission SARS-CoV-2 from mother neonate is rare, and who do become with generally have favorable outcomes. In this review, the authors evaluate existing on its potential...

10.3390/encyclopedia3010002 article EN cc-by Encyclopedia 2022-12-26
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