A5031206323- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ovarian cancer diagnosis and treatment
- Hormonal Regulation and Hypertension
- Sperm and Testicular Function
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Research Studies
- Reproductive Biology and Fertility
- Cancer Treatment and Pharmacology
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Corneal Surgery and Treatments
- MicroRNA in disease regulation
- Neuroscience of respiration and sleep
- Developmental Biology and Gene Regulation
- Heart Rate Variability and Autonomic Control
- RNA Research and Splicing
- Maternal Mental Health During Pregnancy and Postpartum
- Cancer Immunotherapy and Biomarkers
- Neonatal Respiratory Health Research
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
Hospital Universitario Fundación Alcorcón
2013-2024
Universidad de Granada
2016-2024
Centro Andaluz de Biología del Desarrollo
2024
Instituto de Investigación Sanitaria del Principado de Asturias
2024
Max Delbrück Center
2021-2023
NYU Langone Health
2018
Research Institute Hospital 12 de Octubre
2016
Hospital Universitario Virgen del Rocío
2013
Hospital Universitario Puerta de Hierro Majadahonda
2006-2008
New York State Psychiatric Institute
2000-2001
This study examined the effect of an acute maternal stress response and anxiety on fetal heart rate. Seventeen healthy, 3rd-trimester pregnant women (mean age = 26 +/- 6 years) were instrumented for continuous electrocardiography, blood pressure (BP), respiration, rate (HR). Subjects completed state subscale State Trait Personality Inventory (STPI), then rested quietly in a semirecumbent position 5-min baseline period, followed by either arithmetic or Stroop color-word task. Over entire...
Nutritional deficiency is a common medical problem that affects 15–40% of cancer patients. It negatively impacts their quality life and can compromise treatment completion. Oncological therapies, such as surgery, radiation therapy, drug therapies are improving survival rates. However, all these treatments play role in the development malnutrition and/or metabolic alterations patients, induced by tumor or its treatment. assessment patients necessary at time diagnosis throughout treatment, so...
The new concept of mammalian sex maintenance establishes that particular key genes must remain active in the differentiated gonads to avoid genetic reprogramming, as described adult ovaries after Foxl2 ablation. Dmrt1 plays a similar role postnatal testes, but mechanism testis remains mostly unknown. Sox9 and Sox8 are required for male fertility, their has not been investigated. Here we show ablation Sertoli cells adult, fertile Sox8-/- mice, testis-to-ovary reprogramming occurs...
Intersexuality in female moles Female are intersexual and develop masculinizing ovotestes, a distinctive trait among mammals. Real et al. investigated the origin of this by sequencing Iberian mole genome applying comparative strategies that integrate transcriptomic, epigenetic, chromatin interaction data. They identified mole-specific genomic rearrangements alter three-dimensional regulatory landscape androgen-converting gene CYP17A1 pro-testicular factor FGF9 , both which show distinct...
Abstract Introduction Deregulation of Polycomb member Bmi-1 is involved in cell proliferation and human oncogenesis. Modulation found several tumor tissues, including primary breast carcinomas; however, analysis plasma cancer patients has not been reported. This the first study that evaluates by using a large series carcinomas to investigate presence at diagnosis detectable mRNA possible correlations between this event clinical-pathological parameters tumors. Methods expression levels were...
Abstract Mammalian sex determination is controlled by antagonistic gene cascades operating in embryonic undifferentiated gonads. The expression of the Y-linked SRY sufficient to trigger testicular pathway, whereas its absence XX embryos leads ovarian differentiation. Yet, potential involvement non-coding regulation this process remains unclear. Here we show that deletion a single microRNA cluster, miR-17 ~ 92 , induces complete primary male-to-female reversal XY mice. Sry delayed knockout...
To develop and validate a nomogram web-based calculator to predict overall survival (OS) in Caucasian-advanced oesophagogastric adenocarcinoma (AOA) patients undergoing first-line combination chemotherapy. Nine hundred twenty-four AOA treated at 28 Spanish teaching hospitals from January 2008 September 2014 were used as derivation cohort. The result of an adjusted-Cox proportional hazards regression was represented calculator. model validated 502 prospectively recruited between October...
Research into cancer-associated thrombosis (CAT) entails managing dynamic data that pose an analytical challenge. Thus, methods assume proportional hazards to investigate prognosis entail a risk of misinterpreting or overlooking key traits time-varying effects. We examined the AGAMENON registry, which collects from 2,129 patients with advanced gastric cancer. An accelerated failure time (AFT) multistate model and flexible competing risks regression were used scrutinize effect CAT, as well...
Pituitary apoplexy (PA) is the paradigm of endocrine and neurosurgical emergency.
Second-line treatments boost overall survival in advanced gastric cancer (AGC). However, there is a paucity of information as to patterns use and the results achieved actual clinical practice.The study population comprised patients with AGC AGAMENON registry who had received second-line. The objective was describe pattern second-line therapies administered, progression-free following (PFS-2), post-progression since first-line (PPS).2311 cases 2066 progression events (89.3%) were recorded;...
Abstract Purpose: Thymidylate synthase (TS), a critical target in fluorouracil-based chemotherapy, is prognostic marker colon carcinomas and predictor of response to treatment. Tumor RNA has been detected plasma from cancer patients associated with poor prognosis. This the first study examine extracellular TS mRNA carcinoma, its possible relation promoter enhancer region (TSER) polymorphism. Experimental Design: expression was measured 88 26 controls, tumor subgroup this series by...
Originally published by the American Society of Clinical Oncology. Garcia-Donas et al.: Journal Oncology Vol. 31.10, April 1 - 2013: e165-e166
Testes of seasonally breeding species experience a severe functional regression before the non-breeding period, which implies substantial mass reduction due to massive germ-cell depletion. Two alternative mechanisms seasonal depletion have been described in mammals, apoptosis and desquamation (sloughing), but their prevalence has not determined yet reduced number studied. We performed morphological, hormonal, molecular study mechanism testicular males Egyptian long eared-hedgehog...
Prior research in newborns has shown that head-up and head-down tilting elicits sustained increases decreases heart rate, respectively. Other studies older infants have suggested the pattern of rate responses to varies with risk for sudden infant death syndrome (SIDS). In this study, respiratory changes following bidirectional were recorded sleeping on Day 1 or 2 life, during period maximum SIDS, at 4 months age. Newborns show 30° tilts 300 tilting. Respiratory rates decreased but did not...
MicroRNAs are frequently organized into polycistronic clusters whose transcription is controlled by a single promoter. The miR-17-92 cluster expressed in most embryonic and postnatal organs. It potent oncogene associated to several types of cancer it involved important developmental processes. In the testis, expression germ cells necessary maintain normal spermatogenesis. This also Sertoli (the somatic seminiferous tubules), which require miRNAs for correct cell development survival. To...
The identification of new genes involved in sexual development and gonadal function as potential candidates causing male infertility is important for both diagnostic therapeutic purposes. Deficiency the onco-miRNA cluster miR-17∼92 has been shown to disrupt spermatogenesis, whereas mutations its paralog cluster, miR-106b∼25, that expressed same cells, were reported have no effect on testis function. aim this work determine role these two miRNA clusters spermatogenesis fertility. For this, we...
ABSTRACT Mammalian sex is determined by opposing networks of ovarian and testicular genes that are well characterized. However, its epigenetic regulation still largely unknown, thus limiting our understanding a fundamental process for species propagation. Here we explore the 3D chromatin landscape determination in vivo , profiling FACS-sorted embryonic mouse gonadal populations, prior after determination, both sexes. We integrate Hi-C with ChIP-seq experiments using METALoci novel genome...