A5069697618- Birth, Development, and Health
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Maternal Mental Health During Pregnancy and Postpartum
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Adipose Tissue and Metabolism
- Gestational Diabetes Research and Management
- Prenatal Substance Exposure Effects
- Neuroendocrine regulation and behavior
- Eating Disorders and Behaviors
- Attention Deficit Hyperactivity Disorder
- Neonatal and fetal brain pathology
- Gut microbiota and health
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- COVID-19 Impact on Reproduction
- Infant Nutrition and Health
- Biochemical Analysis and Sensing Techniques
- Cannabis and Cannabinoid Research
- Primate Behavior and Ecology
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Neural dynamics and brain function
Oregon National Primate Research Center
2016-2025
Oregon Health & Science University
2016-2025
University of Oregon
2018-2023
Child Mind Institute
2023
University of Portland
2011-2018
University of Oxford
2016
University of California, San Francisco
2008
Institute of Livestock and Grassland Science
2004
University of Guelph
2004
Monash Institute of Medical Research
2004
Childhood obesity is associated with increased risk of behavioral/psychological disorders including depression, anxiety, poor learning, and attention deficient disorder. As the majority women child-bearing age are overweight or obese consume a diet high in dietary fat, it critical to examine consequences maternal overnutrition on development brain circuitry that regulates offspring behavior. Using nonhuman primate model diet-induced obesity, we found high-fat (HFD) consumption caused...
Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational cross-species comparative neuroscience. Unfortunately, the technological methodological advances past two decades have outpaced accrual data, which particularly challenging given relatively few centers necessary facilities capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human magnetic resonance imaging...
The perinatal environment plays an important role in programming many aspects of physiology and behavior including metabolism, body weight set point, energy balance regulation predisposition to mental health-related disorders such as anxiety, depression attention deficit hyperactivity disorder. Maternal health nutritional status heavily influence the early have a long-term impact on critical central pathways, melanocortinergic, serotonergic system dopaminergic systems. Evidence from variety...
Objective To utilize a nonhuman primate model to examine the impact of maternal high-fat diet (HFD) consumption and pre-pregnancy obesity on offspring intake palatable food whether HFD impaired development dopamine system, critical for regulation hedonic feeding. Methods The exposure diets varying composition was assessed after weaning. influence prefrontal cortex-dopaminergic system at 13 months age also examined. Results During preference test, exposed displayed increased high in fat sugar...
The aperiodic exponent of the electroencephalogram (EEG) power spectrum has received growing attention as a physiological marker neurodevelopmental psychopathology, including attention-deficit/hyperactivity disorder (ADHD). However, its use ADHD risk across development, and particularly in very young children, is limited by unknown reliability, difficulty aligning canonical band-based measures development periods, unclear effects treatment later development. Here, we investigate internal...
Abstract The impact of COVID-19-related stress on perinatal women is heightened public health concern given the established intergenerational maternal stress-exposure infants and fetuses. There urgent need to characterize coping styles associated with adverse psychosocial outcomes in during COVID-19 pandemic help mitigate potential for lasting sequelae both mothers infants. This study uses a data-driven approach identify patterns behavioral strategies that associate distress large...
The association between physical activity (PA) and C‐reactive protein (CRP) is inconsistent, with nearly all studies using self‐report measures of PA. purpose this study was to examine the objectively measured PA CRP in US adults children. Adults ( N =2912) children =1643) valid accelerometer data were included analyses. Logistic regression analysis used assess odds meeting guidelines across quartiles for among low, average, high levels. For adults, after adjustments age, gender, race, body...
Background Attention deficit hyperactivity disorder ( ADHD ) is theorized to have temperamental precursors early in life. These are difficult identify because many core features of , such as breakdowns executive function and self‐control, involve psychological neural systems that too immature reliably show dysfunction also involves emotional dysregulation, these appear earlier well. Here, we report a first attempt utilize indices regulation ‐related liability infancy. Methods Fifty women...
Perinatal exposure to maternal obesity and high-fat diet (HFD) consumption not only poses metabolic risks offspring, but also impacts brain development mental health. Using a nonhuman primate model, we observed persistent increase in anxiety juvenile offspring exposed HFD. Post-weaning HFD increased independently stereotypic pacing. These behavioral changes were associated with modified cortisol stress response impairments the of central serotonin synthesis, altered tryptophan hydroxylase-2...
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent, impairing, and highly heritable condition typically diagnosed in middle childhood. However, it now recognized that symptoms emerge much earlier development. Research focused on understanding-using multiple units of analysis-the cascade early-life (i.e., prenatal-infant-toddler) developmental changes will later as ADHD has the potential to transform early identification, prevention, intervention. To this end, we introduce...
There are large individual differences in the daily pattern and level of physical activity humans other species. As it is becoming apparent that plays an integral role a number physiological processes including arousal, attention, cardiovascular health body weight regulation, there increased interest quantifying activity. Nonhuman primates particularly useful experimental models for such studies they exhibit repertoire more similar to than animals as rodents domestic animals. Recent...
Purpose To determine whether gadolinium remains in juvenile nonhuman primate tissue after maternal exposure to intravenous gadoteridol during pregnancy. Materials and Methods Gravid rhesus macaques their offspring (n = 10) were maintained, as approved by the institutional animal care utilization committee. They prospectively studied part of a pre-existing ongoing research protocol evaluate effects malnutrition on placental fetal development. On gestational days 85 135, they underwent...
Complementing long-standing traditions centered on histology, fMRI approaches are rapidly maturing in delineating brain areal organization at the macroscale. The non-human primate (NHP) provides opportunity to overcome critical barriers translational research. Here, we establish data requirements for achieving reproducible and internally valid parcellations individuals. We demonstrate that functional boundaries serve as a fingerprint of individual animals can be achieved under anesthesia or...