A5025402084- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Nicotinic Acetylcholine Receptors Study
- Stress Responses and Cortisol
- Anesthesia and Sedative Agents
- Legal principles and applications
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Olfactory and Sensory Function Studies
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Neuroendocrine regulation and behavior
- Advanced MRI Techniques and Applications
- Memory Processes and Influences
- Primate Behavior and Ecology
- Cardiac, Anesthesia and Surgical Outcomes
- Neurotransmitter Receptor Influence on Behavior
- Sleep and Wakefulness Research
- Autism Spectrum Disorder Research
- EEG and Brain-Computer Interfaces
- Genetics and Neurodevelopmental Disorders
Wake Forest University
2022-2025
Advanced Manufacturing Research Centre
2025
University of Sheffield
2025
Icahn School of Medicine at Mount Sinai
2015-2024
University of Oxford
2006-2024
Allen Institute for Brain Science
2014-2023
VA Connecticut Healthcare System
2014-2022
Yale University
2014-2022
Southampton Children's Hospital
2022
Baxter (India)
2020
Goal-directed actions are guided by expected outcomes of those actions. Humans with bilateral damage to ventromedial prefrontal cortex, or the amygdala, deficient in their ability use information about positive and negative guide choice behavior. Similarly, rats monkeys orbital amygdala have been found be impaired responses changing values outcomes. In present study, we tested whether direct, functional interaction between cortex is necessary for guiding behavior based on Unlike control...
Despite the prominence of parietal activity in human neuroimaging investigations sensorimotor and cognitive processes, there remains uncertainty about basic aspects cortical anatomical organization. Descriptions cortex draw heavily on schemes developed other primate species, but validity such comparisons has been questioned by claims that are fundamental differences between humans primates. A scheme is presented for parcellation lateral into component regions basis connectivity functional...
Background: Recent population studies have suggested that children with multiple exposures to anesthesia and surgery at an early age are increased risk of cognitive impairment.The authors therefore established animal model single versus anesthetic(s) in young adult mice, aiming distinguish the role different types impairment.Methods: Six-and 60-day-old mice were exposed various regimens.The then determined effects on learning memory function, levels proinflammatory cytokine interleukin-6...
The orbitofrontal cortex (OFC) has been implicated in reinforcement-guided decision making, error monitoring, and the reversal of behavior response to changing circumstances. anterior cingulate sulcus (ACC S ), however, also similar aspects behavior. Dissociating unique functions these areas would improve our understanding decision-making process. effect selective OFC lesions on how monkeys used history reinforcement guide choices either particular actions or stimuli was studied compared...
Male Long-Evans rats were given injections of either 192 IgG-saporin, an apparently selective toxin for basal forebrain cholinergic neurons (LES), or vehicle (CON) into the medial septum and vertical limb diagonal band (MS/VDB) bilaterally nucleus basalis magnocellularis substantia innominata (nBM/SI). Place discrimination in Morris water maze assessed spatial learning, a trial-unique matching-to-place task memory place information over varying delays. MS/VDB-LES nBM/SI-LES not impaired...
Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational cross-species comparative neuroscience. Unfortunately, the technological methodological advances past two decades have outpaced accrual data, which particularly challenging given relatively few centers necessary facilities capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human magnetic resonance imaging...
In the absence of external stimuli or task demands, correlations in spontaneous brain activity (functional connectivity) reflect patterns anatomical connectivity. Hence, resting-state functional connectivity has been used as a proxy measure for structural and biomarker changes disease. To relate to physiological brain, it is important understand how depend on physical integrity tissue. The causal nature this relationship called into question by patient data suggesting that decreased does not...
Retrospective studies in humans have shown a higher prevalence of learning disabilities children that received multiple exposures to general anesthesia before the age 4 yr. Animal studies, primarily rodents, found postnatal anesthetic exposure causes neurotoxicity and neurocognitive deficits adulthood. The authors addressed question whether repeated was sufficient cause long-term behavioral changes highly translationally relevant rhesus monkey model, allowing study these variables against...
Abstract Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, longevity factor, could enhance cognition human-relevant models such as nonhuman primates unknown and represents knowledge gap the path to therapeutics. We validated rhesus form of klotho protein mice showing it increased synaptic plasticity cognition. then found that single administration low-dose, but not high-dose, enhanced memory aged primates. Systemic low-dose may prove therapeutic humans.
Aged rats have spatial memory deficits relative to young rats. The extent of these in intermediate-aged is not well established. present study examined the pattern age-related changes reference and working four ages Fischer-344 Place discrimination (PD) Morris water maze measured memory. Repeated acquisition (RA), a which escape platform location varied from session session, rats, 4 months, 11 17 24 months age, were tested. Compared 4-month-olds, 24-month-olds significantly impaired on all...
The authors demonstrated previously that isoflurane-nitrous oxide anesthesia attenuates performance improvement on an already-learned spatial memory task and the effect persists for weeks. This experiment was designed to test hypothesis learning of new information is particularly susceptible prolonged disruption after general anesthesia.Six- (n = 5) 20- month-old male Fischer 344 rats were anesthetized 2 h with 1.2% isoflurane, 70% nitrous oxide, 30% oxygen. Age-matched control received...
Studies demonstrate lasting cognitive impairment in elderly persons after anesthesia and surgery. We tested the hypothesis that general contributes to this impairment. Six- 18-mo-old Fischer 344 rats were trained a 12-arm radial arm maze then randomized for 2 h with 1.2% isoflurane/70% nitrous oxide/30% oxygen or control treatment consisting of 30% oxygen. Rats recovered 24 daily on 8 wk. Performance young was stable throughout experiment. In contrast, aged improved their performance as...
Abstract Persistent suppression of N ‐methyl‐ d ‐aspartate (NMDA) receptor function produces enduring structural changes in neocortical and limbic regions a pattern similar to reported schizophrenia. This similarity suggests that chronic NMDA antagonism animals may represent useful model neurobiological related cognitive deficits Schizophrenia is associated with impairments frontal lobe‐dependent functions, including working memory attentional shifting. Deficits attention executive have not...
Normal aging is associated with disruption of neural systems that subserve different aspects cognitive function, particularly in the hippocampus and frontal cortex. Abnormalities hippocampal function have been well investigated rodent models aging, but studies cortex aged rodents are few. We tested young (4–5 mo old) (27–28 male Long-Evans rats on an attentional set-shifting task modified slightly from previous publication. After training two problems which reward was consistently same...
Context: Diagnostic criteria for eating disorders influence how we recognize, research, and treat disorders, empirically valid phenotypes are required revealing their genetic bases.Objective: To define disorder phenotypes.Design: Data regarding symptoms features from 1179 individuals with clinically significant were submitted to a latent class analysis.The resulting classes compared on noneating variables in series of validation analyses.Setting: Multinational, collaborative study cases...
Mutations in the synaptic gene SHANK3 lead to a neurodevelopmental disorder known as Phelan-McDermid syndrome (PMS). PMS is relatively common monogenic and highly penetrant cause of autism spectrum (ASD) intellectual disability (ID), frequently presents with attention deficits. The underlying neurobiology not fully pharmacological treatments for core symptoms do exist. Here, we report production characterization Shank3-deficient rat model PMS, genetic alteration similar human mutation. We...
Neonatal exposure to general anesthetics may pose significant neurocognitive risk. Human epidemiological studies demonstrate higher rates of learning disability among children with multiple, but not single, exposures anesthesia. The authors employ a rat model provide histological correlate for these population-based observations. examined long-term differences in hippocampal synaptic density, mitochondrial and dendritic spine morphology.Twenty male pups (n = 5/condition) were exposed 2.5%...