A5033157082- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Musicology and Musical Analysis
- Advanced MRI Techniques and Applications
- American Constitutional Law and Politics
- Memory Processes and Influences
- American History and Culture
- Nerve injury and regeneration
- American Environmental and Regional History
- Medical Imaging Techniques and Applications
- Diverse Musicological Studies
- Neurogenesis and neuroplasticity mechanisms
- Race, History, and American Society
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Historical Economic and Social Studies
- Mormonism, Religion, and History
- Latin American and Latino Studies
- African history and culture analysis
Institut Cellule Souche et Cerveau
2015-2025
Université Claude Bernard Lyon 1
2015-2025
Inserm
2015-2025
Piedmont Atlanta Hospital
2016
University of Mississippi
1984-2011
Sorbonne Université
2011
Institut Systèmes Intelligents et de Robotique
2011
University of Oxford
1962-2010
University of British Columbia
2005
Cardiff University
2004
Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational cross-species comparative neuroscience. Unfortunately, the technological methodological advances past two decades have outpaced accrual data, which particularly challenging given relatively few centers necessary facilities capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human magnetic resonance imaging...
In the absence of external stimuli or task demands, correlations in spontaneous brain activity (functional connectivity) reflect patterns anatomical connectivity. Hence, resting-state functional connectivity has been used as a proxy measure for structural and biomarker changes disease. To relate to physiological brain, it is important understand how depend on physical integrity tissue. The causal nature this relationship called into question by patient data suggesting that decreased does not...
Anatomical and functional studies of the prefrontal cortex (PFC) have identified multiple PFC subregions. We argue that is involved in cognitive functions exceeding sum specific attributed to its These can be revealed either by lesions whole PFC, or more specifically selective disconnection from certain types information (for example, visual) allowing investigation function toto. Recent macaque monkeys using latter approach lead a second conclusion: as whole, could fundamentally specialized...
Abstract Although the relative expansion of frontal cortex in primate evolution is generally accepted, nature human uniqueness, if any, and between-species anatomo-functional comparisons areas remain controversial. To provide a novel interpretation brains, sulcal morphological variability medial was assessed Old World monkeys (macaque/baboon) Hominoidea (chimpanzee/human). We show that both possess paracingulate sulcus, which previously thought to be unique brain linked higher cognitive...
Frontal beta oscillations are associated with top-down control mechanisms but also change over time during a task. It is unclear whether represents another function or neural instantiation of vigilance decrements time, the time-on-task effect. We investigated how frontal modulated by cognitive and time. used chronic electrocorticography in monkeys performing trial-and-error task, comprising search repetition phases. Specific delay period each trial were task phase adaptation to feedback....
Detailed neuroscientific data from macaque monkeys have been essential in advancing understanding of human frontal cortex function, particularly for regions without homologs other model species. However, precise transfer this knowledge direct use applications requires an monkey to hominid homologies, whether and how sulci cytoarchitectonic the macaques relate those hominids. We combine sulcal pattern analysis with resting-state functional magnetic resonance imaging show that old-world brains...
The sulcal morphology of the human medial frontal cortex has received marked interest because (1) its remarkable link with functional organization this region, and (2) observations that deviations from 'normal' morphological variability correlate prevalence some psychiatric disorders, cognitive abilities, or personality traits. Unfortunately, background studies on environmental genetic factors influencing ontogenesis in region are critically lacking. We analysed twins non-twin siblings, as...
Abstract The neuronal connections between the midcingulate cortex (MCC) and dorsolateral prefrontal (dlPFC) are associated with multiple cognitive functions, including rapid long-term adaptive processes. Here we show that DREADD-mediated activation of MCC to dlPFC projection in macaques led increased engagement a foraging task, but did not alter their trial-to-trial strategy. We conclude critical role for MCC-dlPFC pathway is temporally extended control behaviour rather than adaptation.
In neurophysiological research, the traditional view of beta band activity as sustained oscillations is being reinterpreted transient bursts. Bursts are characterized by a distinct wavelet shape, high amplitude, and, most importantly, brief temporal occurrence. The primary method for their detection relies on threshold-based analysis spectral power, and this presents two fundamental issues. First, threshold selection effectively arbitrary, influenced both temporally proximal distal factors...
The relationship between anterograde and retrograde amnesia remains unclear. Previous data from both clinical neuropsychology monkey lesion studies suggest that damage to discrete subcortical structures leads a relatively greater degree of than amnesia, whereas regions cortex the opposite pattern impairments. Nevertheless, medial diencephalon in humans is associated with amnesia. In present study, we sought reconcile this by assessing retention as well subsequent relearning new postoperative...
Abstract Identifying the evolutionary origins of human speech remains a topic intense scientific interest. Here we describe unique feature adult neuroanatomy compared to chimpanzees and other primates that may provide an explanation changes occurred enable capacity for speech. That is Prefrontal extent Frontal Operculum (PFOp) region, which located in ventrolateral prefrontal cortex, adjacent ventromedial classical Broca’s area. We also show that, chimpanzees, individuals with most...
Prefrontal cortex (PFC) is thought to have a wide-ranging role in cognition, often described as executive function or behavioral inhibition. A specific example of such the inhibition representations more posterior regions “top-down” manner, be tested by reversal learning tasks. The direct action PFC on can directly disconnecting from region question. We whether inhibits visual object inferotemporal (IT) during studying effect, macaque monkeys, IT crossed unilateral ablations. two tasks,...
Both frontal-inferotemporal disconnection and fornix transection (Fx) in the monkey impair object-in-place scene learning, a model of human episodic memory. If contribution to learning is via interaction with or modulation frontal-temporal interaction--that is, if they form unitary system--then Fx should have no further effect when added disconnection. However, some extent distinct, then lesions may produce an additional deficit beyond that caused by To distinguish between these...
It has been hypothesized that some fornical fibres may instantiate a neuromodulatory reinforcement signal supporting memory acquisition in medial temporal cortical regions. This suggests fornix transection should impair postoperative new learning more severely than the recall of preoperatively acquired information. Here, 288 concurrent visuo-spatial discrimination problems was unaffected after macaque, whereas 72 impaired. and other recent evidence supports idea main function macaque monkeys...
Abstract A critical aspect of neuroscience is to establish whether and how brain networks evolved across primates. To date, most comparative studies have used resting-state functional magnetic resonance imaging (rs-fMRI) in anaesthetized nonhuman primates awake humans. However, anaesthesia strongly affects rs-fMRI signals. The present study investigated the impact awareness state (anaesthesia vs. awake) within same group macaque monkeys on connectivity organization a well-characterized...
Abstract Parkinson's disease (PD) evolves over an extended and variable period in humans; years prior to the onset of classical motor symptoms, sleep biological rhythm disorders develop, significantly impacting quality‐of‐life patients. Circadian‐rhythm are accompanied by mild cognitive deficits that progressively worsen with progression can constitute a severe burden for patients at later stages. The gold‐standard 6‐methyl‐1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridin (MPTP) macaque model PD...