A5081543817- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neurogenesis and neuroplasticity mechanisms
- Visual perception and processing mechanisms
- Nerve injury and regeneration
- Parkinson's Disease Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Healthcare Systems and Practices
- Occupational Health and Safety Research
- Health, Medicine and Society
- Lipid metabolism and disorders
- Memory and Neural Mechanisms
- Pluripotent Stem Cells Research
- Clusterin in disease pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Retinal Development and Disorders
- Mind wandering and attention
- Neural and Behavioral Psychology Studies
- Advanced Fluorescence Microscopy Techniques
Inserm
2012-2025
Université Claude Bernard Lyon 1
2010-2025
Institut Cellule Souche et Cerveau
2010-2025
Université Paris-Saclay
2017
Retrograde tracer injections in 29 of the 91 areas macaque cerebral cortex revealed 1,615 interareal pathways, a third which have not previously been reported. A weight index (extrinsic fraction labeled neurons [FLNe]) was determined for each area-to-area pathway. Newly found projections were weaker on average compared with known projections; nevertheless, 2 sets pathways had extensively overlapping distributions. Repeat across individuals modest FLNe variability given range values (standard...
ABSTRACT The laminar location of the cell bodies and terminals interareal connections determines hierarchical structural organization cortex has been intensively studied. However, we still have only a rudimentary understanding connectional principles feedforward (FF) feedback (FB) pathways. Quantitative analysis retrograde tracers was used to extend notion that distribution neurons interconnecting visual areas provides an index distance (percentage supragranular labeled [SLN]). We show that:...
To what extent cortical pathways show significant weight differences and whether these are consistent across animals (thereby comprising robust connectivity profiles) is an important unresolved neuroanatomical issue. Here we report a quantitative retrograde tracer analysis in the cynomolgus macaque monkey of consistency afferents areas brains via calculation index (fraction labeled neurons, FLN). Injection 8 (3 occipital plus 5 other lobes) revealed pattern: small subcortical input (1.3%...
We investigated the influence of interareal distance on connectivity patterns in a database obtained from injection retrograde tracers 29 areas distributed over six regions (occipital, temporal, parietal, frontal, prefrontal, and limbic). One-third 1,615 pathways projecting to target were reported only recently deemed new-found projections (NFPs). NFPs are predominantly long-range, low-weight connections. A minimum dominating set analysis (a graph theoretic measure) shows that play major...
Claustrum orchestrates brain functions via its connections with numerous regions, but molecular and cellular organization remains unresolved. Single-nucleus RNA sequencing of 227,750 macaque claustral cells identified 48 transcriptome-defined cell types, most glutamatergic neurons similar to deep-layer insular neurons. Comparison macaque, marmoset, mouse transcriptomes revealed macaque-specific types. Retrograde tracer injections at 67 cortical 7 subcortical regions defined four distinct...
Abstract The neuronal connections between the midcingulate cortex (MCC) and dorsolateral prefrontal (dlPFC) are associated with multiple cognitive functions, including rapid long-term adaptive processes. Here we show that DREADD-mediated activation of MCC to dlPFC projection in macaques led increased engagement a foraging task, but did not alter their trial-to-trial strategy. We conclude critical role for MCC-dlPFC pathway is temporally extended control behaviour rather than adaptation.
Abstract Feedback connections play a major role in many theories of brain function. Previous studies feedback to early visual areas have mainly concentrated on the representation central fields. Here, injections tracers at different eccentricities V1 and V2 revealed retinotopically organized feedback. Peripheral projections from 15 that are not labeled by injections. Connection strengths for majority vary significantly with eccentricity systematic fashion respect distance origin; whereas...
Abstract Parkinson's disease (PD) evolves over an extended and variable period in humans; years prior to the onset of classical motor symptoms, sleep biological rhythm disorders develop, significantly impacting quality‐of‐life patients. Circadian‐rhythm are accompanied by mild cognitive deficits that progressively worsen with progression can constitute a severe burden for patients at later stages. The gold‐standard 6‐methyl‐1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridin (MPTP) macaque model PD...
Cette année encore, dans le cadre du module d’enseignement « Physiopathologie de la signalisation » proposé par l’université Paris-sud, les étudiants Master Biologie Santé Paris-Saclay se sont confrontés à l’écriture scientifique. Ils ont sélectionné 12 articles scientifiques récents domaine cellulaire présentant des résultats originaux, via approches expérimentales variées, sur thèmes allant interactions hôte-pathogène au métabolisme, en passant compétition et microbiote. Après un travail...
Abstract Parkinson’s disease (PD) evolves over an extended and variable period in humans; several years prior to the onset of classical motor symptoms, cognitive deficits as well sleep biological rhythm disorders develop worsen with progression, significantly impacting quality life patients. The gold standard MPTP macaque model PD recapitulates progression non-motor symptoms contracted periods time. Here, this multidisciplinary multiparametric study follows, five animals, steady describes...
Abstract Cognitive deficits as well disorders of sleep and biological rhythms constitute non-motor symptoms that significantly impact quality life in Parkinson’s disease patients. Few studies have evaluated the cell replacement therapy on such symptoms. Here we used a multidisciplinary approach to assess therapeutic potential bilateral grafts neural stem cells macaque model both motor markers functional recovery. Grafts led varying degrees recovery while sham experiments did not. We show...