A5027470309- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Neuroscience and Neural Engineering
- Down syndrome and intellectual disability research
- Sleep and Wakefulness Research
- ECG Monitoring and Analysis
- Seismic Waves and Analysis
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and disorders
- Seismic Imaging and Inversion Techniques
- Geophysical and Geoelectrical Methods
- Clusterin in disease pathology
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Neonatal and fetal brain pathology
Institut du Cerveau
2020-2022
Inserm
2020-2021
Sorbonne Université
2020-2021
Institut Pasteur
2020
ORCID
2020
Centre National de la Recherche Scientifique
2020
Université Paris-Saclay
2017
Down syndrome (DS) results in various degrees of cognitive deficits. In DS mouse models, recovery behavioral and neurophysiological deficits using GABAAR antagonists led to hypothesize an excessive activity inhibitory circuits this condition. Nonetheless, whether over-inhibition is present due specific alterations distinct GABAergic unknown. the prefrontal cortex Ts65Dn mice (a well-established model), we found that dendritic synaptic loop formed by somatostatin-positive Martinotti cells...
Perisomatic inhibition of pyramidal neurons (PNs) coordinates cortical network activity during sensory processing, and this role is mainly attributed to parvalbumin-expressing basket cells (BCs). However, cannabinoid receptor type 1 (CB1)-expressing interneurons are also BCs, but the connectivity function these elusive prominent neocortical inhibitory unclear. We find that their pattern visual area specific. Persistently active CB1 signaling suppresses GABA release from BCs in medial...
Abstract Down syndrome (DS) results in various degrees of cognitive deficits. In DS mouse models, recovery behavioral and neurophysiological deficits using GABA A R antagonists led to hypothesize an excessive activity inhibitory circuits this condition. Nonetheless, whether over-inhibition is present due specific alterations distinct GABAergic unknown. the prefrontal cortex Ts65Dn mice (a well-established model), we found that dendritic synaptic loop formed by somatostatin-positive...
Cette année encore, dans le cadre du module d’enseignement « Physiopathologie de la signalisation » proposé par l’université Paris-sud, les étudiants Master Biologie Santé Paris-Saclay se sont confrontés à l’écriture scientifique. Ils ont sélectionné 12 articles scientifiques récents domaine cellulaire présentant des résultats originaux, via approches expérimentales variées, sur thèmes allant interactions hôte-pathogène au métabolisme, en passant compétition et microbiote. Après un travail...
Summary Perisomatic inhibition of neocortical pyramidal neurons (PNs) coordinates cortical network activity during sensory processing, and it has been mainly attributed to parvalbumin-expressing basket cells (BCs). However, cannabinoid receptor type 1 (CB1)-expressing interneurons also inhibit the perisomatic region PNs but connectivity function these elusive – yet prominent GABAergic is unknown. We found that pattern CB1-positive BCs strongly differs between primary high-order visual areas....
SummaryPerisomatic inhibition of neocortical pyramidal neurons (PNs) coordinates cortical network activity during sensory processing, and it has been mainly attributed to parvalbumin-expressing basket cells (BCs). However, cannabinoid receptor type 1 (CB1)-expressing interneurons also inhibit the perisomatic region PNs but connectivity function these elusive – yet prominent GABAergic is unknown. We found that pattern CB1-positive BCs strongly differs between primary high-order visual areas....