A5031250664- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Visual perception and processing mechanisms
- Neural and Behavioral Psychology Studies
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Neuroscience and Neuropharmacology Research
- Neural Networks and Applications
- Multisensory perception and integration
- Neuroscience and Neural Engineering
- Advanced Neuroimaging Techniques and Applications
- Nonlinear Dynamics and Pattern Formation
- Anatomy and Medical Technology
- Health, Environment, Cognitive Aging
- Cell Image Analysis Techniques
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Neonatal and fetal brain pathology
- Machine Learning in Healthcare
- Single-cell and spatial transcriptomics
- Action Observation and Synchronization
Institut Cellule Souche et Cerveau
2013-2025
Inserm
2013-2025
Université Claude Bernard Lyon 1
2012-2025
Ernst Strüngmann Institute for Neuroscience
2014-2024
Max Planck Society
2014
Zero to Three
2013
Retrograde tracer injections in 29 of the 91 areas macaque cerebral cortex revealed 1,615 interareal pathways, a third which have not previously been reported. A weight index (extrinsic fraction labeled neurons [FLNe]) was determined for each area-to-area pathway. Newly found projections were weaker on average compared with known projections; nevertheless, 2 sets pathways had extensively overlapping distributions. Repeat across individuals modest FLNe variability given range values (standard...
ABSTRACT The laminar location of the cell bodies and terminals interareal connections determines hierarchical structural organization cortex has been intensively studied. However, we still have only a rudimentary understanding connectional principles feedforward (FF) feedback (FB) pathways. Quantitative analysis retrograde tracers was used to extend notion that distribution neurons interconnecting visual areas provides an index distance (percentage supragranular labeled [SLN]). We show that:...
To what extent cortical pathways show significant weight differences and whether these are consistent across animals (thereby comprising robust connectivity profiles) is an important unresolved neuroanatomical issue. Here we report a quantitative retrograde tracer analysis in the cynomolgus macaque monkey of consistency afferents areas brains via calculation index (fraction labeled neurons, FLN). Injection 8 (3 occipital plus 5 other lobes) revealed pattern: small subcortical input (1.3%...
Frontal beta oscillations are associated with top-down control mechanisms but also change over time during a task. It is unclear whether represents another function or neural instantiation of vigilance decrements time, the time-on-task effect. We investigated how frontal modulated by cognitive and time. used chronic electrocorticography in monkeys performing trial-and-error task, comprising search repetition phases. Specific delay period each trial were task phase adaptation to feedback....
Cognitive functions are subserved by rhythmic neuronal synchronization across widely distributed brain areas. In 105 area pairs, we investigated functional connectivity (FC) through coherence, power correlation, and Granger causality (GC) in the theta, beta, high-beta, gamma rhythms. Between rhythms, spatial FC patterns were largely independent. Thus, rhythms defined distinct interaction networks. Importantly, networks of coherence GC not explained distributions strengths Those networks,...
Disturbances of the daily sleep/wake cycle are common non-motor symptoms Parkinson's disease (PD). However, impact dopamine (DA) depletion on circadian rhythms in PD patients or non-human primate (NHP) models disorder have not been investigated. We evaluated alterations NHP following MPTP lesion dopaminergic nigro-striatal system. DA degeneration was assessed by vivo PET ([(11)C]-PE2I) and post-mortem TH DAT quantification. In a light∶dark cycle, control MPTP-treated both exhibit rest-wake...
Cognitive functioning requires coordination between brain areas. Between visual areas, feedforward gamma synchronization improves behavioral performance. Here, we investigate whether similar principles hold across regions and frequency bands, using simultaneous electrocorticographic recordings from 15 areas of two macaque monkeys during performance a selective attention task. Short reaction times (RTs), suggesting efficient interareal communication, occurred when occipital V1, V2, V4, DP...
Claustrum orchestrates brain functions via its connections with numerous regions, but molecular and cellular organization remains unresolved. Single-nucleus RNA sequencing of 227,750 macaque claustral cells identified 48 transcriptome-defined cell types, most glutamatergic neurons similar to deep-layer insular neurons. Comparison macaque, marmoset, mouse transcriptomes revealed macaque-specific types. Retrograde tracer injections at 67 cortical 7 subcortical regions defined four distinct...
Background It is increasingly recognized that non-motor symptoms are a prominent feature of Parkinson's disease and in the case cognitive deficits can precede onset characteristic motor symptoms. Here, we examine 4 monkeys chronically treated with low doses neurotoxin MPTP early long-term alterations rest-activity rhythms relationship to appearance Methodology/Principal Findings Behavioral activity recordings as well assessments were carried out continuously parallel before, during for...
Visual cortical areas are thought to form a hierarchy and subserve cognitive functions by interacting in both feedforward feedback directions. While influences convey sensory signals, modulate brain responses given stimulus according the current behavioural context. Many studies have demonstrated effects of on driven behaviour. Also, anatomical projections directions been identified. However, although these revealed paths neurophysiological consequences directions, mechanisms through which...
Hierarchical predictive coding theory (hPC) proposes that perception arises from the integration of bottom-up (BU) pathways carrying sensory evidence with top-down (TD) carring priors and expectations. However, there is surprising little concerning location functional mechanisms underlying such BU-TD integration. This can be overcome by future parallel experiments in humans non-human primates (NHPs). Molecular characterization NHP cortico-cortical BU TD projection cell types will allow...
Here we propose a roadmap for addressing hierarchical predictive coding theory (hPC) in the primate brain. hPC proposes that perception arises from integration of bottom-up (BU) pathways carrying sensory evidence with top-down (TD) priors and expectations. However, there is surprising little concerning location functional mechanisms underlying such BU-TD integration. This can be overcome by future parallel experiments humans non-human primates (NHPs). Molecular characterization NHP...
Here we propose a roadmap for addressing hierarchical predictive coding theory (hPC) in the primate brain, theorizing that perception arises from integration of bottom-up (BU) pathways carrying sensory evidence with top-down (TD) priors and expectations. However, given conceptual importance hPC higher cognitive function humans there is surprising little concerning location functional mechanisms underlying such BU-TD integration. This will be overcome by parallel experiments non-human...
Feedback monitoring and adaptation of performance involve a medial reward system including frontal cortical areas, the striatum, dopaminergic system. A considerable amount data has been obtained on surface feedback-related potentials (FRPs) in humans correlate outcome with single unit activity monkeys. However, work is needed to bridge knowledge two species. The present describes FRPs monkeys, using chronic recordings, during trial error task. We show that are differentially sensitive...
Abstract Parkinson's disease (PD) evolves over an extended and variable period in humans; years prior to the onset of classical motor symptoms, sleep biological rhythm disorders develop, significantly impacting quality‐of‐life patients. Circadian‐rhythm are accompanied by mild cognitive deficits that progressively worsen with progression can constitute a severe burden for patients at later stages. The gold‐standard 6‐methyl‐1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridin (MPTP) macaque model PD...
Neurophysiological studies with awake macaques typically require chronic cranial implants. Headpost and connector-chamber implants are used to allow head stabilization house connectors of chronically implanted electrodes, respectively. We present long-lasting, modular, cement-free headpost made titanium that consist two pieces: a baseplate top part. The is first, covered by muscle skin allowed heal osseointegrate for several weeks months. percutaneous part added in second, brief surgery....
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As the European Flagship Human Brain Project (HBP) ends in September 2023, a meeting dedicated to Partnering Projects (PPs), collective of independent research groups that partnered with HBP, was held on 4–7, 2022. The purpose this allow these present their results, reflect collaboration HBP and discuss future interactions Research Infrastructure (RI) EBRAINS has emerged from HBP. In report, we share tour-de-force were have made furthering knowledge concerning various aspects We describe...