A5089701687- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Visual perception and processing mechanisms
- Advanced Neuroimaging Techniques and Applications
- Tactile and Sensory Interactions
- Neural and Behavioral Psychology Studies
- Regional Development and Management Studies
- Primate Behavior and Ecology
- EEG and Brain-Computer Interfaces
- Geological Formations and Processes Exploration
- Balkan and Eastern European Studies
- Advanced Fluorescence Microscopy Techniques
- Pleistocene-Era Hominins and Archaeology
- Obsessive-Compulsive Spectrum Disorders
- Neural Networks and Applications
- Attention Deficit Hyperactivity Disorder
- Advanced Memory and Neural Computing
- Cell Image Analysis Techniques
- Transcranial Magnetic Stimulation Studies
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- Cognitive Science and Education Research
- Financial Literacy, Pension, Retirement Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Computational Drug Discovery Methods
Princeton University
2018-2024
Buck Institute for Research on Aging
2022
Trakia University
2017
Institut Cellule Souche et Cerveau
2009-2013
Université Claude Bernard Lyon 1
2010-2013
Yale University
2012-2013
Inserm
2009-2013
Zero to Three
2013
Retrograde tracer injections in 29 of the 91 areas macaque cerebral cortex revealed 1,615 interareal pathways, a third which have not previously been reported. A weight index (extrinsic fraction labeled neurons [FLNe]) was determined for each area-to-area pathway. Newly found projections were weaker on average compared with known projections; nevertheless, 2 sets pathways had extensively overlapping distributions. Repeat across individuals modest FLNe variability given range values (standard...
ABSTRACT The laminar location of the cell bodies and terminals interareal connections determines hierarchical structural organization cortex has been intensively studied. However, we still have only a rudimentary understanding connectional principles feedforward (FF) feedback (FB) pathways. Quantitative analysis retrograde tracers was used to extend notion that distribution neurons interconnecting visual areas provides an index distance (percentage supragranular labeled [SLN]). We show that:...
To what extent cortical pathways show significant weight differences and whether these are consistent across animals (thereby comprising robust connectivity profiles) is an important unresolved neuroanatomical issue. Here we report a quantitative retrograde tracer analysis in the cynomolgus macaque monkey of consistency afferents areas brains via calculation index (fraction labeled neurons, FLN). Injection 8 (3 occipital plus 5 other lobes) revealed pattern: small subcortical input (1.3%...
We investigated the influence of interareal distance on connectivity patterns in a database obtained from injection retrograde tracers 29 areas distributed over six regions (occipital, temporal, parietal, frontal, prefrontal, and limbic). One-third 1,615 pathways projecting to target were reported only recently deemed new-found projections (NFPs). NFPs are predominantly long-range, low-weight connections. A minimum dominating set analysis (a graph theoretic measure) shows that play major...
Cognition is remarkably flexible; we are able to rapidly learn and perform many different tasks
Aging is characterized by a progressive loss of brain volume at an estimated rate 5% per decade after age 40. While these morphometric changes, especially those affecting gray matter and atrophy the temporal lobe, are predictors cognitive performance, strong association with aging obscures potential parallel, but more specific role, individual subject physiology. Here, we studied cohort 554 human subjects who were monitored using structural MRI scans blood immune protein concentrations....
Attention filters sensory inputs to enhance task-relevant information. It is guided by an "attentional template" that represents the stimulus features are currently relevant. To understand how brain learns and uses templates, we trained monkeys perform a visual search task required them repeatedly learn new attentional templates. Neural recordings found templates were represented across prefrontal parietal cortex in structured manner, such perceptually neighboring had similar neural...
There is little understanding of the structural underpinnings functional reorganization cortex in congenitally blind human. Taking advantage extensive characterization macaque visual system, we examine influence congenital blindness resulting from removal retina during utero development. This effectively removes normal thalamus on cortical development leading to an induced hybrid (HC) combining features primary and extrastriate cortex. Retrograde tracers injected HC reveal a local, intrinsic...
Abstract There is an extensive modification of the functional organization brain in congenital blind human, although there little understanding structural underpinnings these changes. The visual system macaque has been extensively characterized both anatomically and functionally. We have taken advantage this to examine influence blindness a model developmental anophthalmia. Developmental anophthalmia effectively removes normal thalamus on cortical development leading induced “hybrid cortex...
Transcranial direct current stimulation (tDCS) has been demonstrated in randomized clinical trials (RCTs) to be an effective treatment option for major depressive disorder (MDD). The aim of this study was characterize the real-life effectiveness and tolerability tDCS identify predictors outcome patients with MDD. A total 462 symptoms, who were treated as a part routine practice, enrolled study. Depressive symptoms evaluated using validated depression scales before after 410 completed whom...
Abstract Attention filters sensory inputs to enhance task-relevant information. It is guided by an ‘attentional template’ that represents the stimulus features are relevant for current task. To understand how brain learns and uses new templates, we trained monkeys perform a visual search task required them repeatedly learn attentional templates. Neural recordings found templates were represented across prefrontal parietal cortex in structured manner, such perceptually neighboring had similar...
Local government in Bulgaria is determined by strong legal regulation, significant imbalances and heterogeneity.Municipalities have different socio-economic demographic potential.This defines conclusions regarding the budget process, which a basic attestation of volume municipal commitments resources for their implementation.The aim study to present quantitative measures that define municipality as "a difficulty" on this basis some summaries recommendations.The uses general specific methods...
Abstract There is extensive modification of the functional organization brain in congenital blind human, although there little understanding structural underpinnings these changes. The visual system macaque has been extensively characterized both anatomically and functionally. We have taken advantage this to examine influence blindness resulting from removal retina during utero development. Developmental anophthalmia effectively removes normal thalamus on cortical development leading an...