A5067979606- Hemispheric Asymmetry in Neuroscience
- Primate Behavior and Ecology
- Child and Animal Learning Development
- Morphological variations and asymmetry
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Action Observation and Synchronization
- Memory and Neural Mechanisms
- Animal Vocal Communication and Behavior
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Face Recognition and Perception
- Evolutionary Psychology and Human Behavior
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Comparative Animal Anatomy Studies
- Hearing Impairment and Communication
- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- Motor Control and Adaptation
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology of Language and Bilingualism
- Spatial Cognition and Navigation
- Spatial Neglect and Hemispheric Dysfunction
The University of Texas MD Anderson Cancer Center
2015-2025
National Aeronautics and Space Administration
2024
Georgia State University
2012-2022
Victoria University
2022
Centre National de la Recherche Scientifique
1993-2022
Aix-Marseille Université
2017-2022
Allen Institute for Brain Science
2020
Emory National Primate Research Center
2010-2019
Wild Chimpanzee Foundation
2019
Cambridge Cognition (United Kingdom)
2017
Two pygmy champanzees (Pan paniscus) have spontaneously begun to use symbols communicate with people.In contrast common chimpanzees troglodytes) using the same communicative system, did not need explicit training in order form referential symbolobject associations.Instead, they acquired by observing others these daily communications them.In addition, comprehend spoken English words and can readily identify lexigrams upon hearing words.By contrast, who received similar exposure are unable do...
Significance Despite decades of research, we still have a very incomplete understanding what is special about the human brain compared with brains our closest fossil and living relatives. Parsing genetic versus environmental factors that govern structure cerebral cortex in humans chimpanzees may shed light on evolution behavioral flexibility lineage. We show morphology substantially less genetically heritable than therefore more responsive to molding by influences. This anatomical property...
Identifying potentially unique features of the human cerebral cortex is a first step to understanding how evolution has shaped brain in our species. By analyzing MR images obtained from 177 humans and 73 chimpanzees, we observed human-specific asymmetry superior temporal sulcus at heart communication regions which have named "superior asymmetrical pit" (STAP). This 45-mm-long segment ventral Heschl's gyrus deeper right hemisphere than left 95% typical subjects, infanthood till adulthood,...
The cognitive abilities of humans are distinctive among primates, but their molecular and cellular substrates poorly understood. We used comparative single-nucleus transcriptomics to analyze samples the middle temporal gyrus (MTG) from adult humans, chimpanzees, gorillas, rhesus macaques, common marmosets understand human-specific features neocortex. Human, chimpanzee, gorilla MTG showed highly similar cell-type composition laminar organization as well a large shift in proportions deep-layer...
Hand preference for a coordinated bimanual task was assessed in sample of 110 chimpanzees (Pan troglodytes). Subjects were presented with opaque tubes, the inside which coated peanut butter. The hand and finger used to extract butter recorded 2 test sessions. A population right-hand bias found. Juvenile adolescent subjects less lateralized than adults. All primarily their index Use higher adults adolescents compared juveniles. results suggest that tasks (a) elicit strong preferences at...
Faces are one of the most salient classes stimuli involved in social communication. Three experiments compared face-recognition abilities chimpanzees (Pan troglodytes) and rhesus monkeys (Macaca mulatta). In face-matching task, matched identical photographs conspecifics' faces on Trial 1, did same after 4 generalization trials. individual-recognition 2 different individual trials, generalized fewer than 6 The feature-masking task showed that eyes were important cue for recognition. Thus,...
Neural changes that occurred during human evolution to support language are poorly understood. As a basis of comparison humans, we used design-based stereological methods estimate volumes, total neuron numbers, and densities in Brodmann's areas 44 45 both cerebral hemispheres 12 chimpanzees (Pan troglodytes), one our species' closest living relatives. We found the degree interindividual variation topographic location quantitative cytoarchitecture was comparable seen humans from previous...
Whether nonhuman primates exhibit population-level handedness remains a topic of considerabe theoretical and empirical debate. One continued subject discussion is whether evidence in confined to studies captive animals or it both wild subjects. Here, we report chimpanzees for tool-use task known as “termite-fishing.” We subsequently compared the termite-fishing with other published reports on nut-cracking wadge-dipping found task-specific differences handedness. Last, when combing all data...
Abstract An enigmatic feature of age‐related neurodegenerative diseases is that they seldom, if ever, are fully manifested in nonhuman species under natural conditions. The tauopathies typified by the intracellular aggregation hyperphosphorylated microtubule‐associated protein tau (MAPT) and dysfunction death affected neurons. We document first case tauopathy with paired helical filaments an aged chimpanzee ( Pan troglodytes ). Pathologic forms neuronal somata, neuropil threads, plaque‐like...
The primate cerebral cortex is characterized by regional variation in the structure of pyramidal neurons, with more complex dendritic arbors and greater spine density observed prefrontal compared sensory motor cortices. Although there are several investigations humans other primates, virtually nothing known about morphology neurons great apes, humans' closest living relatives. current study uses rapid Golgi stain to quantify layer III 4 areas chimpanzee cortex: Primary somatosensory (area...
Neocortical development in humans is characterized by an extended period of synaptic proliferation that peaks mid-childhood, with subsequent pruning through early adulthood, as well relatively delayed maturation neuronal arborization the prefrontal cortex compared sensorimotor areas. In macaque monkeys, cortical synaptogenesis during infancy and developmental changes synapse density dendritic spines occur synchronously across regions. Thus, prolonged might contribute to enhancement social...
Several biological changes characterize normal brain aging in humans. Although some of these age-associated neural alterations are also found other species, overt volumetric decline particular structures, such as the hippocampus and frontal lobe, has only been observed However, comparable data on effects regional volumes have not previously available from our closest living relatives, chimpanzees. In this study, we used MRI to measure volume whole brain, total neocortical gray matter, white...
Abstract Although the relative expansion of frontal cortex in primate evolution is generally accepted, nature human uniqueness, if any, and between-species anatomo-functional comparisons areas remain controversial. To provide a novel interpretation brains, sulcal morphological variability medial was assessed Old World monkeys (macaque/baboon) Hominoidea (chimpanzee/human). We show that both possess paracingulate sulcus, which previously thought to be unique brain linked higher cognitive...
Increased connectivity of high-order association regions in the neocortex has been proposed as a defining feature human brain evolution. At present, however, there are limited comparative data to examine this claim fully. We tested hypothesis that distribution neuropil across areas humans differs from one our closest living relatives, common chimpanzee. The provides proxy measure total within local region because it is composed mostly dendrites, axons, and synapses. Using image analysis...