A5001237444- Neurotransmitter Receptor Influence on Behavior
- Attention Deficit Hyperactivity Disorder
- Behavioral and Psychological Studies
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Pharmacological Effects and Assays
- Biochemical Analysis and Sensing Techniques
- Obesity, Physical Activity, Diet
- Olfactory and Sensory Function Studies
- Nicotinic Acetylcholine Receptors Study
- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- SAS software applications and methods
- Hormonal Regulation and Hypertension
- Schizophrenia research and treatment
- Sensory Analysis and Statistical Methods
- Cannabis and Cannabinoid Research
- Phosphodiesterase function and regulation
- Smoking Behavior and Cessation
- Education and Critical Thinking Development
- Cholinesterase and Neurodegenerative Diseases
- Impact of Technology on Adolescents
Mercer University
2022-2023
Valdosta State University
2018
Florida State University
2010-2011
University of Iowa
2005-2010
Harvard University
2002-2004
University of Minnesota
1993-1999
University of North Carolina at Chapel Hill
1999
University of Minnesota Medical Center
1994-1997
Twin Cities Orthopedics
1993-1996
University of Pittsburgh
1992-1993
Evaluated children's choice for sedentary versus vigorous activity. Experiment 1 assessed the influence of percent overweight (less than 20%, 20% to 80%, greater 80%) on a moderately liked activity at constant variable ratio (VR) 2 reinforcement schedule highly with varied from VR2 VR32. All children chose when schedules were VR2. As cost increased, lean and obese switched activity, but very still compared between easily accessible, or least activities (VR2) through VR16. When equal, rated...
Abstract Persistent suppression of N ‐methyl‐ d ‐aspartate (NMDA) receptor function produces enduring structural changes in neocortical and limbic regions a pattern similar to reported schizophrenia. This similarity suggests that chronic NMDA antagonism animals may represent useful model neurobiological related cognitive deficits Schizophrenia is associated with impairments frontal lobe‐dependent functions, including working memory attentional shifting. Deficits attention executive have not...
Neuronal nicotinic α7 acetylcholine receptors (α7nAChRs) are expressed primarily in the brain and implicated modulating many cognitive functions (e.g., attention, working episodic memory). Not surprisingly, much effort has been committed to development of molecules acting at α7nAChRs as potential therapies for a variety central nervous system diseases Alzheimer9s). <i>N</i>-[(3<i>S</i>)-1-azabicyclo[2.2.2]oct-3-yl]-1<i>H</i>-indazole-3-carboxamide hydrochloride (RG3487) binds potently human...
Efficient attention to our environment facilitates the decisions that need be executed in daily life. Filtering critical from noncritical information may require neural organization of multiple brain regions. Combining lesion techniques and rodent version Wisconsin card sorting task humans, we show at least two types attentional processing systems reside cingulate prefrontal cortices depending on demands requiring shifts within or between sets meaningful cues, respectively. This for shifting...
Abstract Impairments in multiple aspects of attentional and executive function follow damage to cholinergic neurons the central nervous system. Affective set‐shifting represent two controlled by different sectors prefrontal cortex. The involvement neural mechanisms these has not been specified. To determine whether muscarinic receptors were involved affective and/or set‐shifting, we tested rats on a series discrimination learning problems, which included (reversal learning) set...
The atypical antipsychotic sertindole is a phenylindole-derived compound that has affinity for and functions as an antagonist at number of receptor systems, including dopamine D2 receptors, 5-HT(2A) 5-HT(2C) α-1-noradrenergic receptors. Although previous data suggested was well tolerated had good efficacy against both positive negative symptom clusters, reports QT prolongation with prompted its voluntary removal from the market in 1998. After further safety analyses, it recently regained...