A5026870436- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Venous Thromboembolism Diagnosis and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Central Venous Catheters and Hemodialysis
- Cerebrovascular and Carotid Artery Diseases
- Diagnosis and Treatment of Venous Diseases
- Acute Ischemic Stroke Management
- Liver Disease Diagnosis and Treatment
- Software Engineering Research
- Cardiac Imaging and Diagnostics
- Photoacoustic and Ultrasonic Imaging
- Advanced X-ray and CT Imaging
- Usability and User Interface Design
- Software Reliability and Analysis Research
- Radiology practices and education
- Radiation Dose and Imaging
- Nanoplatforms for cancer theranostics
- AI in cancer detection
- Moyamoya disease diagnosis and treatment
- Ultrasound Imaging and Elastography
Stanford University
2015-2024
Stanford Medicine
2011-2023
University of Pennsylvania
2021-2023
Sunnybrook Health Science Centre
2023
Center for Clinical Research (United States)
2023
University of Utah
2023
Uniformed Services University of the Health Sciences
2023
Madigan Army Medical Center
2023
VA Palo Alto Health Care System
2023
Lucile Packard Children's Hospital
2016-2021
Empirical software engineering research needs guidelines to improve the and reporting processes. We propose a preliminary set of aimed at stimulating discussion among researchers. They are based on review developed for medical researchers our own experience in doing reviewing research. The intended assist researchers, reviewers, meta-analysts designing, conducting, evaluating empirical studies. Editorial boards journals may wish use recommendations as basis developing reviewers framing...
PET gene reporter imaging can be used to monitor the trafficking of therapeutic cytotoxic T cells in glioma patients.
Conventional angiography has been historically considered the gold standard for diagnosis of cervical artery dissection, but MR imaging/MR (MRA) and CT/CT (CTA) are commonly used noninvasive alternatives. The goal this study was to compare ability multidetector CT/CTA imaging/MRA detect common imaging findings dissection.Patients in data base our Stroke Center between 2003 2007 with dissections who had on initial work-up were reviewed retrospectively. Two neuroradiologists evaluated images...
Human induced pluripotent stem cells (hiPSCs) and human embryonic (hESCs) are promising candidate cell sources for regenerative medicine. However, despite the common ability of hiPSCs hESCs to differentiate into all 3 germ layers, their functional equivalence at single level remains be demonstrated. Moreover, heterogeneity amongst populations may underlie important fate decisions. Here, we used analysis resolve gene expression profiles 362 an array 42 genes that characterize differentiated...
Determining the presence and adequacy of collateral blood flow is important in cerebrovascular disease. Therefore, we explored whether a noninvasive imaging modality, arterial spin labeling (ASL) MRI, could be used to detect intensity using digital subtraction angiography (DSA) stable xenon CT cerebral as gold standards for collaterals flow, respectively.ASL DSA were obtained within 4 days each other 18 patients with Moyamoya Two neurointerventionalists scored images grading scale regions...
Purpose To develop and validate a dual-targeted ultrasonographic (US) imaging agent with microbubbles (MBs) that attaches to both vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) αvβ3 integrin compare the US signal obtained from MBs (MBD) single-targeted (MBS) in murine model of tumor angiogenesis. Materials Methods Animal protocols were approved by institutional Administrative Panel on Laboratory Care. Single- agents prepared attaching anti-VEGFR2, anti–αvβ3 integrin, or...
Purpose To develop and test human kinase insert domain receptor (KDR)-targeted microbubbles (MBs) (MBKDR) for imaging KDR at the molecular level monitoring antiangiogenic therapy in a colon cancer xenograft tumor model mice. Materials Methods Animal studies were approved by Institutional Administrative Panel on Laboratory Care. A heterodimeric peptide that binds to with low nanomolar affinity (KD = 0.5 nmol/L) was coupled onto surface of perfluorobutane-containing lipid-shelled MBs (MBKDR)....
To evaluate the use of molecularly targeted microbubbles (MBs) and ultrasonography (US) in noninvasive assessment level expression three angiogenic markers, α(v)β(3) integrin, endoglin, vascular endothelial growth factor receptor (VEGFR) 2, on tumor cells vivo during growth.All procedures using laboratory animals were approved by Institutional Administrative Panel Laboratory Animal Care. Binding specificity types MBs (MB(Integrin), MB(Endoglin), MB(VEGFR2)) was tested cell culture under flow...
Purpose To test whether plasmid-binding cationic microbubbles (MBs) enhance ultrasound-mediated gene delivery efficiency relative to control neutral MBs in cell culture and vivo tumors mice. Materials Methods Animal studies were approved by the institutional animal care committee. Cationic characterized terms of size, charge, circulation time, DNA binding. Click beetle luciferase (CBLuc) reporter plasmids mixed with or MBs. The ability protect bound from nuclease degradation was tested means...
<h3>Objective</h3> To test the hypothesis that transcranial magnetic resonance–guided focused ultrasound (tcMRgFUS) thalamotomy is effective, durable, and safe for patients with medication-refractory essential tremor (ET), we assessed clinical outcomes at 3-year follow-up of a controlled multicenter prospective trial. <h3>Methods</h3> Outcomes were based on Clinical Rating Scale Tremor, including hand combined tremor–motor (scale 0–32), functional disability postural 0–4) scores, total...
CD47 monoclonal antibodies (mAbs) activate tumor-associated macrophages (TAMs) in sarcomas to phagocytose and eliminate cancer cells. Though mAbs have entered clinical trials, diagnostic tests for monitoring therapy response vivo are currently lacking. Ferumoxytol is an FDA-approved iron supplement which can be used "off label" as a contrast agent: the nanoparticle-based drug phagocytosed by TAM detected with magnetic resonance imaging (MRI). We evaluated if ferumoxytol-enhanced MRI monitor...
Skull density ratio (SDR) assesses the transparency of skull to ultrasound. Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy in essential tremor (ET) patients with a lower SDR may be less effective, and risk for complications increased. To address these questions, authors analyzed clinical outcomes MRgFUS based on SDRs.
Source lines of code (SLOC) is perhaps the oldest software metrics, and still a benchmark for evaluating new ones. Despite extensive experience with SLOC metric, there are number misconceptions about it. The paper addresses three them: (1) that format relevant to how properly count it (a simple experiment shows that, in fact, does not matter), (2) most useful as predictor quality (in fact covariate other predictors), (3) an important inverse relationship between defect density size this...
It is widely believed that overlapping windows are preferable to tiled (non-overlapping) ones, but there very little research support belief. An analysis of the basic characteristics windowing regimes predicts are, in fact, situations where inferior tiled. experiment test this prediction verified indeed tasks and users for which yield faster performance. This result suggests a need closer study principles underlying regimes, so designers have better understanding tradeoffs involved using them.
The purpose of this study is to determine patients' preferences for how, from whom, and how soon they receive imaging results.Hard copies our survey were randomly distributed patients at an academic medical center outpatient facility 9 weeks, during August through October 2008, collect data regarding patient received results ("Method"), whom ("Person"), quickly ("Speed").A total 129 (23%) 557 (47.4% male; median age, 55 years) undergoing CT (62%) MRI (38%) completed the survey. According...
DAVFs and small AVMs are difficult to detect on conventional MR imaging/MRA or CTA examinations often require DSA for definitive diagnosis. The purpose of this study was assess the value venous signal intensity ASL imaging making diagnosis.Two neuroradiologists 1 neurologist reviewed studies in 26 patients, 15 whom had DSA-proved (<2 cm) AVMs. Pseudocontinuous performed at 1.5T with background-suppressed 3D-FSE readout. Using a 5-point scale, these readers assessed likelihood positive...