A5068369502- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Health, Environment, Cognitive Aging
- Spatial Cognition and Navigation
- Neurological Disease Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Associations and Epidemiology
- Advanced MRI Techniques and Applications
- Menopause: Health Impacts and Treatments
- Down syndrome and intellectual disability research
- Advanced Neuroimaging Techniques and Applications
- Cancer-related cognitive impairment studies
- Visual perception and processing mechanisms
- Fatty Acid Research and Health
- Estrogen and related hormone effects
- Older Adults Driving Studies
- Cerebrovascular and Carotid Artery Diseases
- Urban Transport and Accessibility
- Frailty in Older Adults
- Stress Responses and Cortisol
- Mental Health Research Topics
- Optical Imaging and Spectroscopy Techniques
- Multisensory perception and integration
Massachusetts General Hospital
2021-2025
Harvard University
2021-2025
University of Toronto
2024
Sunnybrook Health Science Centre
2024
Baycrest Hospital
2020-2023
Brigham and Women's Hospital
2023
Sunnybrook Hospital
2023
Sunnybrook Research Institute
2023
Centre for Addiction and Mental Health
2021
University of East Anglia
2018-2021
Spatial navigation is emerging as a critical factor in identifying preclinical Alzheimer's disease (AD). However, the impact of interindividual ability and demographic risk factors (e.g., APOE, age, sex) on spatial make it difficult to identify persons "at high risk" AD stages. In current study, we use big data (n = 27,108) from Sea Hero Quest (SHQ) game overcome these challenges by investigating whether can be used benchmark highly phenotyped healthy aging laboratory cohort into high- vs....
Postmenopausal females represent around 70% of all individuals with Alzheimer disease. Previous literature shows elevated levels tau in cognitively unimpaired postmenopausal compared age-matched males, particularly the setting high β-amyloid (Aβ). The biological mechanisms associated higher deposition female remain elusive.
Mounting evidence supports sex differences in Alzheimer disease (AD) risk. Vascular and hormonal factors may together contribute to AD risk female adults. We investigated whether age at menopause, vascular risk, history of hormone therapy (HT) containing estrogens influence cognition over a 3-year follow-up period. hypothesized that earlier menopause elevated would have synergistic association with lower cognitive scores HT attenuate this preserve cognition.
Importance Alzheimer disease (AD) predominates in females at almost twice the rate relative to males. Mounting evidence adults without AD indicates that exhibit higher tau deposition than age-matched males, particularly setting of elevated β-amyloid (Aβ), but for sex differences accumulation rates is inconclusive. Objective To examine whether female associated with faster high Aβ (as measured positron emission tomography [PET]) and moderating influence on association between APOE ε4 carrier...
Elucidating the downstream impact of exogenous hormones on aging brain will have far-reaching consequences for understanding why Alzheimer's disease (AD) predominates in women almost twofold over men. We tested extent to which menopausal hormone therapy (HT) use is associated with later-life amyloid-β (Aβ) and tau accumulation using PET N = 146 baseline clinically normal women, aged 51 89 years. Women were scanned a 4.5-year (SD, 2.1; range, 1.3 10.4) 3.5-year 1.5; 1.2 8.1) period Aβ tau,...
Abstract The biological mechanisms underlying women’s increased Alzheimer’s disease (AD) prevalence remain undefined. Previous case/control studies have identified sex-biased molecular pathways, but sex-specific relationships between gene expression and AD endophenotypes, particularly sex chromosomes, are underexplored. With bulk transcriptomic data across 3 brain regions from 767 decedents, we investigated associations post-mortem β-amyloid tau as well antemortem longitudinal cognition. Of...
Abstract INTRODUCTION We investigated whether novel plasma biomarkers are associated with cognition, cognitive decline, and functional independence in activities of daily living across within neurodegenerative diseases. METHODS Glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), phosphorylated tau (p‐tau)181 amyloid beta (Aβ) 42/40 were measured using ultra‐sensitive Simoa immunoassays 44 healthy controls 480 participants diagnosed Alzheimer's disease/mild impairment...
Plasma biomarkers of Alzheimer disease (AD), neuroinflammation, and neurodegeneration are increasingly being used in clinical trials for diagnosis monitoring dementia. However, their association with longitudinal structural brain MRI changes, an important outcome measure across neurodegenerative cerebrovascular diseases, is less known. We investigated how baseline plasma reflect markers progression over time patients diseases. This cohort study included from the Ontario Neurodegenerative...
With the rising burden of dementia globally, there is a need to harmonize research across diverse populations. The Addenbrooke's Cognitive Examination-III (ACE-III) well-established cognitive screening tool diagnose dementia. But have been few efforts standardize use ACE-III cohorts speaking different languages. present study aimed and validate seven Indian languages assess diagnostic accuracy test detect mild impairment (MCI) in context language heterogeneity.The original was adapted...
Abstract Approximately 40% of dementia cases could be prevented or delayed by modifiable risk factors related to lifestyle and environment. These factors, such as depression vascular disease, do not affect all individuals in the same way, likely due inter-individual differences genetics. However, precise nature how genetic profiles interact with brain health is poorly understood. Here we combine multiple data resources, including genotyping postmortem gene expression, map landscape structure...
We propose that boredom, a state associated with sense of meaninglessness, leads to psychological search for meaning in life, which, turn, elevates affirmation heroes. This hypothesis builds on the notion heroes function, part, as sources life. Using correlational model, we found boredom proneness predicted more positive perceptions via searches one’s own In addition, hero seemed prevent by offering These findings contribute an understanding psychologically existential qualities and...
The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer`s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent neuropsychological spatial navigation assessment. At baseline, participants were classified as low-genetic-risk of or AD. calculated two-way mixed effects intraclass correlation coefficients (ICC) for task...
In addition to amyloid and tau pathology, elevated systemic vascular risk, white matter injury, reduced cerebral blood flow contribute late-life cognitive decline. Given the strong collinearity among these parameters, we proposed a framework extract independent latent features underlying decline using Harvard Aging Brain Study (N = 166 cognitively unimpaired older adults at baseline). We used following measures from baseline visit: cortical amyloid, inferior temporal cortex tau, relative...
Path integration spatial navigation processes are emerging as promising cognitive markers for prodromal and clinical Alzheimer’s disease (AD). However, such path changes have been less explored in Vascular Cognitive Impairment (VCI), despite neurovascular change being a major contributing factor to dementia potentially AD. In particular, the sensitivity specificity of impairments VCI compared AD is unclear. current pilot study, we explore performance early stage patient groups hypothesise...
Background: Men with cerebral amyloid angiopathy (CAA) may have an earlier onset of intracerebral hemorrhage and a more hemorrhagic disease course compared to women. In this cohort study, we investigated sex differences in histopathological markers associated amyloid-β burden cognitively impaired individuals patients CAA, using neuropathological data from two autopsy databases. Methods: First, presence parenchymal (Thal score) vascular (CAA severity the National Alzheimer’s Coordinating...
The biological mechanisms underlying the increased prevalence of Alzheimer's disease (AD) in women remain undefined. While previous case/control studies have identified sex-biased molecular pathways, sex-specific relationships between gene expression and AD endophenotypes, particularly involving sex chromosomes, are underexplored. With bulk transcriptomic data across 3 brain regions from 767 decedents, we investigated associations post-mortem β-amyloid tau, as well antemortem longitudinal...