A5019075220- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Health disparities and outcomes
- Advanced Neuroimaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Nutritional Studies and Diet
- Cognitive Functions and Memory
- Blood Pressure and Hypertension Studies
- Neurological Disease Mechanisms and Treatments
- Frailty in Older Adults
- Bioinformatics and Genomic Networks
- Folate and B Vitamins Research
- Genetic Associations and Epidemiology
- Cerebrovascular and Carotid Artery Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Sleep and related disorders
- Cognitive Abilities and Testing
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Global Health Workforce Issues
- Stress Responses and Cortisol
University of Wisconsin–Madison
2015-2025
William S. Middleton Memorial Veterans Hospital
2006-2022
Geriatric Research Education and Clinical Center
2006-2022
University of Iowa
2022
San Diego State University
2022
National Institutes of Health
1996-2022
National Center for Advancing Translational Sciences
2022
University of Wisconsin Health
2022
NYU Langone Health
2022
United States Department of Veterans Affairs
2021
Converging evidence suggests that Alzheimer disease (AD) involves insulin signaling impairment. Patients with AD and individuals at risk for show reduced glucose metabolism, as indexed by fludeoxyglucose F 18-labeled positron emission tomography (FDG-PET).To determine whether resistance predicts AD-like global regional metabolism deficits in late middle-aged participants to examine resistance-predicted variation is associated worse cognitive performance.This population-based, cross-sectional...
Abstract Blood biomarkers indicative of Alzheimer’s disease (AD) pathology are altered in both preclinical and symptomatic stages the disease. Distinctive may be optimal for identification AD or monitoring progression. that correlate with changes cognition atrophy during course could used clinical trials to identify successful interventions thereby accelerate development efficient therapies. When disease-modifying treatments become approved use, blood-based might also inform on treatment...
Insulin resistance (IR) increases Alzheimer's disease (AD) risk. IR is related to greater amyloid burden post-mortem and increased deposition within areas affected by early AD. No studies have examined if associated with an in vivo index of the human brain late middle-aged participants at risk for
To examine whether engagement in physical activity might favorably alter the age-dependent evolution of Alzheimer disease (AD)-related brain and cognitive changes a cohort at-risk, late-middle-aged adults.Three hundred seventeen enrollees Wisconsin Registry for Alzheimer's Prevention underwent T1 MRI; subset also (11)C-Pittsburgh compound B-PET (n = 186) (18)F-fluorodeoxyglucose-PET 152) imaging. Participants' responses on self-report measure current were used to classify them as either...
To determine the relationship between sleep quality and CSF markers of Alzheimer disease (AD) pathology in late midlife.We investigated AD biomarkers a cohort enriched for parental history sporadic AD, Wisconsin Registry Alzheimer's Prevention. A total 101 participants (mean age 62.9 ± 6.2 years, 65.3% female) completed assessments collection were cognitively normal. Sleep was measured with Medical Outcomes Study Scale. assayed amyloid metabolism plaques (β-amyloid 42 [Aβ42]), tau...
Understanding how metabolites are longitudinally influenced by age and sex could facilitate the identification of metabolomic profiles trajectories that indicate disease risk. We investigated metabolomics using longitudinal plasma samples from Wisconsin Registry for Alzheimer's Prevention (WRAP), a cohort participants who were dementia free at enrollment. Metabolomic quantified 2,344 fasting among 1,212 participants, each with up to three study visits. Of 1,097 tested, 623 (56.8%) associated...
Postmenopausal females represent around 70% of all individuals with Alzheimer disease. Previous literature shows elevated levels tau in cognitively unimpaired postmenopausal compared age-matched males, particularly the setting high β-amyloid (Aβ). The biological mechanisms associated higher deposition female remain elusive.
This study investigated differences in retrospective cognitive trajectories between amyloid and tau PET biomarker stratified groups initially cognitively unimpaired participants sampled from the Wisconsin Registry for Alzheimer's Prevention. One hundred sixty-seven individuals (baseline age 59 ± 6 years; 115 females) were by elevated amyloid-β status based on 11C-Pittsburgh compound B (PiB) 18F-MK-6240 imaging. Mixed effects models used to determine if longitudinal a composite of tests...
Background Metabolic syndrome (MetS)—a cluster of cardiovascular risk factors—is linked with cognitive decline and dementia. However, the brain changes underlying this link are presently unknown. In study, we tested relationship between MetS, cerebral blood flow (CBF), white matter hyperintensity burden, gray (GM) volume in cognitively healthy late middle‐aged adults. Additionally, extent to which MetS was associated performance assessed. Design Methods Late adults from Wisconsin Registry...
Higher occupational attainment has previously been associated with increased Alzheimer's disease (AD) neuropathology when individuals are matched for cognitive function, indicating occupation could provide reserve. We examined whether complexity (OCC) associates decreased hippocampal volume and whole-brain atrophy given comparable function in middle-aged adults at risk AD. Participants (n = 323) underwent structural MRI, evaluation, work history assessment. Three ratings (work data, people,...
Polygenic risk scores (PRSs) have been used to combine the effects of variants with small identified by genome-wide association studies. We explore potential for using pathway-specific PRSs as predictors early changes in Alzheimer's disease (AD)-related biomarkers and cognitive funct ion. Participants were from Wisconsin Registry Prevention, a longitudinal study adults who cognitively asymptomatic at enrollment enriched parental history AD. Using genes associated AD International Genomics...
Longitudinal cohort studies of cognitive aging must confront several sources within-person variability in scores. In this article, we compare neuropsychological measures terms longitudinal error variance and relationships with biomarker-assessed brain amyloidosis (Aβ).Analyses used data from the Wisconsin Registry for Alzheimer's Prevention. We quantified age-related trajectories global domain-specific composites their constituent For a subset cerebrospinal fluid or amyloid positron emission...
Subjective memory complaints (SMCs) represent an individual's perception of subtle changes in the absence objective impairment memory. However, it is not fully known whether persons with SMCs harbor brain alterations related to Alzheimer's disease (AD) or they indeed demonstrate poorer cognitive performance.Participants were 261 middle-aged adults (mean age=54.30 years) enrolled Wisconsin Registry for Prevention, a registry cognitively normal at risk AD. They answered question pertaining...
Changes to everyday spoken language ("connected language") are evident in persons with AD dementia, yet little is known about when these changes first detectable on the continuum of cognitive decline. The aim this study was determine if participants very early, subclinical memory declines were also showing connected language. We analyzed samples obtained from a simple picture description task at two time points 264 Wisconsin Registry for Alzheimer's Prevention (WRAP). In parallel, classified...
This study examined the relationship between phonemic and semantic (category) verbal fluency cognitive status in Wisconsin Registry for Alzheimer's Prevention (WRAP), a longitudinal cohort enriched family history of disease. Participants were 283 WRAP subjects (age 53.1[6.5] years at baseline); who had completed three waves assessment, over ∼6 met psychometric criteria either "cognitively healthy" (CH) or amnestic mild impairment (aMCI) using an approach that did not consider scores. CH aMCI...
Abstract Introduction We examined the influence of enrollment factors demonstrated to differ by race on incident mild cognitive impairment and dementia using Alzheimer's Disease Center data. Methods Differences in rates between non‐Latino Whites Blacks ( n = 12,242) were with age‐at‐progression survival models. Models included race, sex, education, source recruitment, health factors, family history dementia. Results No significant differences progression observed cognitively unimpaired...
Introduction This study applies a novel algorithm to longitudinal amyloid positron emission tomography (PET) imaging identify age-heterogeneous trajectory groups, estimate the age and duration (chronicity) of positivity, investigate chronicity in relation cognitive decline tau burden. Methods Cognitively unimpaired participants (n = 257) underwent one four PET scans (Pittsburgh Compound B, PiB). Group-based modeling was applied with 171) model which were combined Bayes theorem positivity....
Residence in a disadvantaged neighborhood associates with adverse health exposures and outcomes, may increase risk for cognitive impairment dementia. Utilization of publicly available, geocoded disadvantage metric could facilitate efficient integration social determinants into models aging.
<h3>Objective</h3> To test the hypothesis that neighborhood-level disadvantage is associated with longitudinal measures of neurodegeneration and cognitive decline in an unimpaired cohort. <h3>Methods</h3> Longitudinal MRI testing data were collected from 601 cognitively participants Wisconsin Registry for Alzheimer9s Prevention Study Disease Research Center clinical Area Deprivation Index was geospatially determined based on participant residence geocode ranked relative to state residence....
Alzheimer's disease biomarkers are becoming increasingly important for characterizing the longitudinal course of disease, predicting timing clinical and cognitive symptoms, recruitment treatment monitoring in trials. In this work, we develop evaluate three methods modelling amyloid accumulation cohorts using PET imaging. We then use these novel approaches to investigate factors that influence onset from impairment continuum. Data were acquired Disease Neuroimaging Initiative (ADNI),...