A5052668077- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Diet and metabolism studies
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Health, Environment, Cognitive Aging
- Folate and B Vitamins Research
- Nutritional Studies and Diet
- Mitochondrial Function and Pathology
- Heart Rate Variability and Autonomic Control
- Bioinformatics and Genomic Networks
- Biochemical effects in animals
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Neurological Disorders and Treatments
- Regulation of Appetite and Obesity
- Gut microbiota and health
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- SARS-CoV-2 and COVID-19 Research
- Diabetes Management and Research
Rutgers, The State University of New Jersey
2024-2025
Iowa State University
2015-2024
University of Iowa
2016-2024
Rutgers Sexual and Reproductive Health and Rights
2023-2024
Johnson University
2024
IAC (United States)
2022
Ames National Laboratory
2018-2020
National Institute on Aging
2012-2017
National Institutes of Health
2014-2017
University of Wisconsin–Madison
2006-2015
Converging evidence suggests that Alzheimer disease (AD) involves insulin signaling impairment. Patients with AD and individuals at risk for show reduced glucose metabolism, as indexed by fludeoxyglucose F 18-labeled positron emission tomography (FDG-PET).To determine whether resistance predicts AD-like global regional metabolism deficits in late middle-aged participants to examine resistance-predicted variation is associated worse cognitive performance.This population-based, cross-sectional...
Insulin resistance (IR) increases Alzheimer's disease (AD) risk. IR is related to greater amyloid burden post-mortem and increased deposition within areas affected by early AD. No studies have examined if associated with an in vivo index of the human brain late middle-aged participants at risk for
Insulin resistance dysregulates glucose uptake and other functions in brain areas affected by Alzheimer disease. may play a role disease etiopathogenesis. This longitudinal study examined whether insulin among late middle-aged, cognitively healthy individuals was associated with 1) less gray matter disease-sensitive regions 2) worse cognitive performance.Homeostasis model assessment of resistance, volume, the Rey Auditory Verbal Learning Test (RAVLT) were acquired 372 participants at...
Background Metabolic syndrome (MetS)—a cluster of cardiovascular risk factors—is linked with cognitive decline and dementia. However, the brain changes underlying this link are presently unknown. In study, we tested relationship between MetS, cerebral blood flow (CBF), white matter hyperintensity burden, gray (GM) volume in cognitively healthy late middle‐aged adults. Additionally, extent to which MetS was associated performance assessed. Design Methods Late adults from Wisconsin Registry...
Alzheimer disease (AD) is characterized by progressive hypometabolism on [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) scans. Peripheral insulin resistance (IR) increases AD risk. No studies have examined associations between FDG metabolism and IR in mild cognitive impairment (MCI) AD, as well MCI conversion to AD. We studied 26 cognitively normal (CN), 194 (39 MCI-progressors, 148 MCI-stable, 2 years after baseline), 60 subjects with baseline FDG-PET from the Alzheimer’s...
Cerebrospinal fluid (CSF) biomarkers T-Tau and Aβ(42) are linked with Alzheimer's disease (AD), yet little is known about the relationship between CSF structural brain alteration in healthy adults. In this study we examined extent to which AD measured predict microstructure indexed by diffusion tensor imaging (DTI) volume T1-weighted imaging. Forty-three middle-aged adults parental family history of received baseline lumbar puncture MRI approximately 3.5 years later. Voxel-wise image...
Chronic neuroinflammation is thought to potentiate medial temporal lobe (MTL) atrophy and memory decline in Alzheimer’s disease (AD). It has become increasingly important find novel immunological biomarkers of or other processes that can track AD development progression. Our study explored which pro- anti-inflammatory cerebrospinal fluid (CSF) best predicted neuropathology over 24 months. Using Disease Neuroimaging Initiative data (N = 285), CSF inflammatory from mass spectrometry multiplex...
Caloric restriction (CR) reduces the pathological effects of aging and extends lifespan in many species, including nonhuman primates, although effect on brain is less well characterized. We used two common indicators aging, motor performance speed iron deposition measured vivo using magnetic resonance imaging, to determine potential CR elderly rhesus macaques eating restricted (n=24, 13 males, 11 females) standard (n=17, 8 9 diets. Both control monkeys showed age-related increases...
Background: One-carbon metabolism coenzymes may influence brain aging in cognitively unimpaired adults. Methods: Baseline data were used from the UK Biobank cohort. Estimated intake of vitamin B6, B12, and folate was regressed onto neural network functional connectivity five resting-state networks. Linear mixed models tested coenzyme main effects interactions with Alzheimer’s disease (AD) risk factors. Results: Increased B6 B12 estimated linked less most networks, including posterior portion...
Insulin signaling dysregulation is related to neural atrophy in hippocampus and other areas affected by neurovascular neurodegenerative disorders. It not known if long-term calorie restriction (CR) can ameliorate this relationship through improved insulin or such an effect might influence task learning performance. To model hypothesis, magnetic resonance imaging was conducted on 27 CR 17 control rhesus monkeys aged 19–31 years from a longitudinal study. Voxel-based regression analyses were...
Gastrointestinal illnesses and dysbiosis are among the most common comorbidities reported in patients with neurodevelopmental disorders. The manuscript reports that C. difficile infection (CDI), predisposed by antibiotic-induced gut dysbiosis, causes significant alterations dopamine metabolism major dopaminergic brain regions mice (P < 0.05). In addition, infected exhibited significantly reduced beta-hydroxylase (DBH) activity compared to controls 0.01). Moreover, a increased serum...
Many risk factors have emerged for novel 2019 coronavirus disease (COVID-19). It is relatively unknown how these collectively predict COVID-19 infection risk, as well a severe (i.e., hospitalization). Among aged adults (69.3 ± 8.6 years) in UK Biobank, data was downloaded 4510 participants with 7539 test cases. We baseline from 10 to 14 years ago, including demographics, biochemistry, body mass, and other factors, antibody titers 20 common rare infectious diseases subset of 80 124...