A5032689640- Gut microbiota and health
- Probiotics and Fermented Foods
- Animal Nutrition and Physiology
- Clostridium difficile and Clostridium perfringens research
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Essential Oils and Antimicrobial Activity
- Listeria monocytogenes in Food Safety
- Genomics and Phylogenetic Studies
- Animal Behavior and Welfare Studies
- Urinary Tract Infections Management
- Food Safety and Hygiene
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Urinary Bladder and Prostate Research
- Diet and metabolism studies
- Pelvic floor disorders treatments
- Kidney Stones and Urolithiasis Treatments
- Urban Agriculture and Sustainability
- Bacterial biofilms and quorum sensing
- Birth, Development, and Health
- Infant Nutrition and Health
- Fermentation and Sensory Analysis
University of Delaware
2025
University of Connecticut
2017-2023
North Carolina State University
2021-2023
University of Maryland, College Park
2019-2021
In chickens, muscle development during embryonic growth is predominantly by myofiber hyperplasia. Following hatch, primarily occurs via hypertrophy of the existing myofibers. Since number set at production more fibers would provide a greater hatch and potential for posthatch hypertrophy. Therefore, to improve performance in broilers, this study investigated effect ovo spray application probiotics on overall morphometry broiler embryos. For study, fertile Ross 308 eggs were sprayed with...
Salmonella Enteritidis (SE), Typhimurium (ST), and Heidelberg (SH) have been responsible for numerous outbreaks associated with the consumption of poultry meat eggs. colonization in chicken is characterized by initial attachment to cecal epithelial cells (CEC) followed dissemination liver, spleen, oviduct. Since critical transmission along food chain continuum, reducing this intestinal association could potentially decrease egg contamination. Hence, study investigated efficacy Lactobacillus...
Gastrointestinal illnesses and dysbiosis are among the most common comorbidities reported in patients with neurodevelopmental disorders. The manuscript reports that C. difficile infection (CDI), predisposed by antibiotic-induced gut dysbiosis, causes significant alterations dopamine metabolism major dopaminergic brain regions mice (P < 0.05). In addition, infected exhibited significantly reduced beta-hydroxylase (DBH) activity compared to controls 0.01). Moreover, a increased serum...
Salmonellosis associated with consumption of mangoes have been traced back to the use contaminated wash water. This highlights critical role water disinfection in mango processing, affecting its quality, and safety. Moreover, steps unique post-harvest handling also create a conducive environment for internalization pathogens into fruit pulp. Currently, no effective treatment exists eliminate internalized from mangoes. Therefore, it is prevent contamination on avert pathogen internalization....
Mitochondrial adaptation during non-alcoholic fatty liver disease (NAFLD) include remodeling of ketogenic flux and sustained tricarboxylic acid (TCA) cycle activity, which are concurrent to onset oxidative stress. Over 70% obese humans have NAFLD diets common weight loss strategies. However, the effectiveness toward alleviating remains unclear. We hypothesized that chronic ketogenesis will worsen metabolic dysfunction stress NAFLD. Mice (C57BL/6) were kept (for 16-wks) on either a low-fat,...
The microbiome profiles of poultry production systems significantly impact bird health, welfare, and the environment. This study investigated influence broiler-rearing on composition commercial backyard chicken farms their environment over time. Understanding these effects is vital for optimizing animal growth, enhancing addressing human environmental health implications. We collected analyzed various samples from farms, revealing significant differences in microbial diversity measurements...
Urinary tract infections (UTI) are the most common hospital-acquired in humans and caused primarily by uropathogenic Escherichia coli (UPEC). Indwelling urinary catheters become encrusted with UPEC biofilms that resistant to antibiotics, resulting chronic infections. Therefore, it is important control on reduce risk for UTIs. This study investigated efficacy of selenium inhibiting inactivating catheters. were inoculated treated 0 35 mM at 37 °C 5 days biofilm inhibition assay. In addition,...
Consumption of raw mangoes has led to multiple Salmonella-associated foodborne outbreaks in the United States. Although several studies have investigated epiphytic fitness Salmonella on fresh produce, there is sparse information available survival under commercial handling and storage conditions. Hence, objective study was evaluate ambient conditions simulating mango packing house importer facility. Further, ability pathogen adhere attach fructoplane also investigated. For attachment assays,...
Urinary tract infections (UTIs) in the United States result more than 7 million hospital visits per year. Uropathogenic Escherichia coli (UPEC) is responsible for 80% of UTIs. Although antibiotics are drug choice to control UTIs, their repeated use has resulted emergence antibiotic-resistant UPEC. Thus, there a need effective alternate strategies UPEC infections. This study investigated efficacy trans-cinnamaldehyde (TC), food-grade molecule present cinnamon, reducing colonization and...
Probiotics are widely used as feed supplements in the poultry industry to promote growth and performance chickens. Specifically, this supplementation starts around time of lay continues through production cycle laying hens. However, embryonic period is critical development metabolically active organs thereby influencing subsequent health productivity adult birds. Therefore, present study investigated potential use probiotics layers. Further, a pilot grow-out was conducted evaluate effect ovo...
The multistate Escherichia coli (E. coli) O157:H7 outbreak associated with in-shell hazelnuts highlights the pathogen's ability to involve non-traditional vehicles in foodborne infections. Furthermore, it underscores significant gaps our knowledge of pathogen survivability and persistence on nuts. Therefore, this study investigated E. attach survive hazelnuts. In-shell were inoculated a four-strain mixture at 7.6 log colony forming units (CFU)/nut by wet or dry inoculation, stored ambient...
Abstract During the normal embryonic-to-neonatal development, chicken liver is subjected to intense lipid burden from high rates of yolk-lipid oxidation and also accumulation yolk-derived newly synthesized lipids carbohydrates. High hepatic lipogenesis are central features non-alcoholic fatty disease (NAFLD) in both rodents humans, but associated with impaired insulin signaling, dysfunctional mitochondrial energetics oxidative stress. However, these adverse effects not apparent embryonic...
Diets rich in fats and carbohydrates aggravate non-alcoholic fatty liver disease (NAFLD), of which mitochondrial dysfunction is a central feature. It not clear whether high-carbohydrate driven 'lipogenic' diet differentially affects oxidative remodeling compared to high-fat 'oxidative' environment. We hypothesized that the environment will chronically sustain function, hastening metabolic during NAFLD. Mice (C57BL/6NJ) were reared on low-fat (LF; 10% fat calories), (HF; 60% or...
Recent recalls of stone fruit due to potential Listeria contamination and associated foodborne outbreaks highlight the risk for pathogen transmission through stone-fruit consumption. Particularly, surface fruits increases cross-contamination produce during processing storage. This highlights need quality control in intended To develop effective food safety practices, it is essential determine critical factors that influence survival. Therefore, this study evaluated ability survive on peaches...
Lactic acid bacteria are known to exhibit probiotic properties through various mechanisms, including competitive exclusion, pathogen inhibition, production of antimicrobial substances, and maintenance eubiosis. Here, we present the draft genome sequence a novel strain, Lactobacillus rhamnosus strain NRRL B-442, which exhibits potent antivirulence activity against Salmonella enterica.
Lactobacillus paracasei DUP 13076 demonstrates antagonistic effects against the foodborne pathogens Salmonella enterica serovars Enteritidis, Typhimurium, and Heidelberg in coculture vitro experiments. Here, we report draft genome sequence of 13076, which has a circular chromosome 3,048,314 bp G+C content 46.3%.
Elevated circulating branched chain amino acid (BCAA) levels are correlated with the development of insulin resistance and type 2 diabetes mellitus in humans. On other hand, BCAA supplementation has been shown to be beneficial improving during chronic liver disease. Furthermore, there is recent evidence significant crosstalk between mitochondrial lipid metabolism. Considering central role dysfunctional metabolism diet-induced obesity non-alcoholic fatty disease (NAFLD), our objective was...
Abstract Gastrointestinal illnesses are one of the most common comorbidities reported in patients with neurodevelopmental diseases, including autism spectrum disorders (ASD). Gut dysbiosis, overgrowth C. difficile , and gut microbiota-associated alterations central neurotransmission have been implicated ASD, where dopaminergic axis plays an important role disease pathogenesis. Human strains produce a significant amount toxic metabolite p-cresol, inhibitor dopamine beta-hydroxylase (DBH),...
Abstract Environmental health and microbiome can affect poultry production in a variety of ways. Poor environmental conditions lead to increased stress, disease, mortality poultry, resulting reduced production. also reduce the diversity microbial populations microbiome, which an risk disease Finally, microorganisms environment be introduced increase Additionally, have significant impacts on microbiome. Poultry farming alter soil water microbiomes through pollution from manure other...