A5003332853- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Motor Control and Adaptation
- EEG and Brain-Computer Interfaces
- Action Observation and Synchronization
- Forecasting Techniques and Applications
- Cognitive Abilities and Testing
- Dementia and Cognitive Impairment Research
- Attention Deficit Hyperactivity Disorder
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neural and Behavioral Psychology Studies
- Meta-analysis and systematic reviews
- Neural Networks and Applications
- Neuroscience, Education and Cognitive Function
- Cell Image Analysis Techniques
- Muscle activation and electromyography studies
- Autism Spectrum Disorder Research
- Blood Pressure and Hypertension Studies
- Explainable Artificial Intelligence (XAI)
- Advanced MRI Techniques and Applications
- Neuroscience and Music Perception
- Parkinson's Disease Mechanisms and Treatments
- Vestibular and auditory disorders
Queen's University
2017-2025
Queens University
2024
Carnegie Mellon University
2023
Brown University
2023
Kingston Health Sciences Centre
2021
University of Victoria
2013-2018
University of Houston - Victoria
2018
University of California, Davis
2018
Oregon Health & Science University
2018
Spaulding Rehabilitation Hospital
2018
Humans vary greatly in their motor learning abilities, yet little is known about the neural processes that underlie this variability. We identified distinct profiles of human sensorimotor adaptation emerged across 2 days learning, linking these to dynamics whole-brain functional networks early on first day when cognitive strategies toward are believed be most prominent. During greater recruitment a network higher-order brain regions, involving prefrontal and anterior temporal cortex, was...
Humans vary greatly in their motor learning abilities, yet little is known about the neural mechanisms that underlie this variability. Recent neuroimaging and electrophysiological studies demonstrate large-scale dynamics inhabit a low-dimensional subspace or manifold, constrained by intrinsic manifold architecture. Here, we asked, using functional MRI, whether subject-level differences excursion from structure can explain across participants. We had subjects perform sensorimotor adaptation...
How the brain learns new motor commands through reinforcement involves distributed neural circuits beyond known frontal-striatal pathways, yet a comprehensive understanding of this broader architecture remains elusive. Here, using human functional MRI ( N = 46, 27 females) and manifold learning techniques, we identified low-dimensional space that captured dynamic changes in whole-brain organization during reward-based trajectory task. By quantifying participants' rates an Actor-Critic model,...
Changes in resting-state functional connectivity (rs-FC) under general anesthesia have been widely studied with the goal of identifying neural signatures consciousness. This work has commonly revealed an apparent fragmentation whole-brain network structure during unconsciousness, which interpreted as reflecting a break-down and disruption brain's ability to integrate information. Here we show, by studying rs-FC varying depths isoflurane-induced nonhuman primates, that this fragmentation,...
Sensorimotor learning is a dynamic, systems-level process that involves the combined action of multiple neural systems distributed across brain. Although much known about specialized cortical support specific components (such as reaching), we know less how function in coordinated manner to facilitate adaptive behavior. To address this gap, our study measured human brain activity using functional MRI (fMRI) while participants performed classic sensorimotor adaptation task and used manifold...
It is well established that movement planning recruits motor-related cortical brain areas in preparation for the forthcoming action. Given an integral component to control of action processing sensory information throughout movement, we predicted might also modulate early areas, readying them during unfolding To test this hypothesis, performed 2 human functional magnetic resonance imaging studies involving separate delayed tasks and focused on premovement neural activity auditory cortex,...
Error-based and reward-based processes are critical for motor learning thought to be mediated via distinct neural pathways. However, recent behavioral work in humans suggests that both can bolstered by the use of cognitive strategies, which may mediate individual differences ability. It has been speculated medial temporal lobe regions, have shown support sequence learning, also strategies error-based reinforcement learning. direct evidence this idea remains sparse. Here we first show better...
Abstract General anesthetics are routinely used to induce unconsciousness, and much is known about their effects on receptor function single neuron activity. Much less how these local manifest at the whole-brain level nor they influence network dynamics, especially past point of induced unconsciousness. Using resting-state functional magnetic resonance imaging (fMRI) with nonhuman primates, we investigated dose-dependent anesthesia temporal modular structure, following loss consciousness. We...
The long-term outcomes of executive functions and intraindividual variability (IIV; i.e., trial-to-trial or across-task in cognitive performance) following concussion are unclear due to inconsistent limited research findings, respectively. Objective: Responding these gaps scientific understanding, the current study aimed assess utility both IIV at predicting history. Method: Altogether 138 self-identified athletes (Mage = 19.9 ± 1.91 years, 60.8% female, 19.6% with one concussion, 18.1% two...
We argue that depending on p-values to reject null hypotheses, including a recent call for changing the canonical alpha level statistical significance from .05 .005, is deleterious finding of new discoveries and progress science. Given blanket variable criterion levels both are problematic, it sensible dispense with testing altogether. There alternatives address study design determining sample sizes much more directly than does; but none tools should replace as magic method giving clear-cut...
Adaptive motor behavior depends on the coordinated activity of multiple neural systems distributed across brain. While role sensorimotor cortex in learning has been well established, how higher-order brain interact with to guide is less understood. Using functional MRI, we examined human during a reward-based task where subjects learned shape their hand trajectories through reinforcement feedback. We projected patterns cortical and striatal connectivity onto low-dimensional manifold space...
Adaptive motor behavior depends on the coordinated activity of multiple neural systems distributed across brain. While role sensorimotor cortex in learning has been well established, how higher-order brain interact with to guide is less understood. Using functional MRI, we examined human during a reward-based task where subjects learned shape their hand trajectories through reinforcement feedback. We projected patterns cortical and striatal connectivity onto low-dimensional manifold space...
Abstract Sensorimotor learning is supported by multiple competing processes that operate concurrently, making it a challenge to elucidate their neural underpinnings. Here, using human functional MRI, we identify three distinct axes of connectivity between the motor cortex and other brain regions during sensorimotor adaptation. These uniquely correspond subjects’ degree implicit learning, performance errors explicit strategy use, involve different networks situated at increasing levels...
We argue that making accept/reject decisions on scientific hypotheses, including a recent call for changing the canonical alpha level from p = .05 to .005, is deleterious finding of new discoveries and progress science. Given blanket variable levels both are problematic, it sensible dispense with significance testing altogether. There alternatives address study design sample size much more directly than does; but none statistical tools should be taken as magic method giving clear-cut...
Abstract Humans vary greatly in their motor learning abilities, yet little is known about the neural processes that underlie this variability. We identified distinct profiles of human sensorimotor adaptation emerged across two days learning, linking these to dynamics whole-brain functional networks early on first day, when cognitive strategies toward are believed be most prominent. During greater recruitment a network higher-order brain regions, involving prefrontal and anterior temporal...
We argue that making accept/reject decisions on scientific hypotheses, including a recent call for changing the canonical alpha level from p = .05 to .005, is deleterious finding of new discoveries and progress science. Given blanket variable levels both are problematic, it sensible dispense with significance testing altogether. There alternatives address study design sample size much more directly than does; but none statistical tools should be taken as magic method giving clear-cut...