A5037347563- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Structural Anomalies and Repair
- ECG Monitoring and Analysis
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Cardiac Ischemia and Reperfusion
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac tumors and thrombi
- Heart Failure Treatment and Management
- Viral Infections and Immunology Research
- Pulmonary Hypertension Research and Treatments
- Medical History and Research
- Healthcare Systems and Practices
- Central Venous Catheters and Hemodialysis
- Cancer Treatment and Pharmacology
- Cerebral Venous Sinus Thrombosis
- Cardiac Arrest and Resuscitation
- Erythropoietin and Anemia Treatment
Clinique Pasteur
2016-2025
Inserm
2007-2011
Université de Montpellier
2011
Centre National de la Recherche Scientifique
2007-2011
Centre Hospitalier Universitaire de Clermont-Ferrand
2007
Centre Antoine Lacassagne
2007
Hôpital Lapeyronie
2007
Abstract Aims Pulsed field ablation (PFA) has emerged as a novel, non-thermal energy source to selectively ablate cardiac tissue. We describe multicentre experience on pulmonary vein isolation (PVI) via the pentaspline Farapulse™ PFA system vs. thermal-based technologies in propensity score-matched population of paroxysmal atrial fibrillation (PAF) patients. Methods and results Propensity score matching was adopted compare PVI-only outcomes Farawave™ (Group PFA), cryoballoon CRYO), or focal...
BACKGROUND: Pulsed field ablation (PFA) is increasingly used in clinical practice for the treatment of atrial fibrillation. While susceptibility erythrocytes to electroporation well established, effect cardiac PFA technologies on hemolysis has remained underreported. The aim this study was investigate incidence, severity, and impact PFA-induced hemolysis. METHODS: We included n=145 patients undergoing fibrillation catheter with a pentaspline (biphasic, bipolar pulses 2 kV) n=70 receiving...
Real‐Time Contact Force Sensing for Pulmonary Vein Isolation Introduction The additional benefit of contact force (CF) technology during pulmonary vein isolation (PVI) paroxysmal atrial fibrillation (AF) to improve mid‐term clinical outcome is unclear. Methods and Results Eligible patients with symptomatic AF were enrolled in this prospective trial, comparing circular antral catheter ablation (guided by Carto 3 System, Biosense Webster) using either a new open‐irrigated CF (SmartTouch...
In the setting of paroxysmal atrial fibrillation (AF), there are no available data comparing mid-term outcome patients undergoing pulmonary vein isolation (PVI) catheter ablation using contact-force (CF)-guided radiofrequency (RF) vs. second-generation balloon cryotherapy. Prospective single-centre evaluation, carried out from March 2011 to February 2013, CF (Thermocool® SmartTouch™, Biosense Webster, Inc.) (CF group) with cryoballoon (Arctic Front Advance™ 28 mm cryoballoon, Medtronic, (CB...
Non-invasive electrocardiogram (ECG) mapping allows the activation of entire atrial epicardium to be recorded simultaneously, potentially identifying mechanisms critical for fibrillation (AF) persistence. We sought evaluate utility ECG as a practical tool prior ablation persistent AF (PsAF) in centres with no experience system. A total 118 patients continuous duration <1 year were prospectively studied at 8 European centres. Patients on median 1 antiarrhythmic drug (AAD) that had failed...
There has been an increasing focus on integrated, multidisciplinary, and holistic care in the treatment of atrial fibrillation (AF). The 'Atrial Fibrillation Better Care' (ABC) pathway proposed to streamline integrated AF. We evaluated impact outcomes ABC adherent management a contemporary real-life European-wide AF cohort.Patients enrolled ESC-EHRA EURObservational Research Programme General Long-Term Registry with baseline data evaluate criteria available follow-up were considered for this...
Fifty-watt radiofrequency applications have proven to be safe and efficient for pulmonary vein isolation (PVI). However, as PV reconnection still occurs ablation catheter instability significantly contributes suboptimal lesion formation, a new capable of delivering 90 W 4 seconds only has been developed with the aim improving PVI outcomes. In this setting, we sought determine whether create transmural lesions without collateral damage experimentally they can safely improve procedures...
Abstract Aims The aim of this study was to compare procedural efficacy and safety, including 1-year freedom from AF recurrence, between the novel cryoballoon system PolarX (Boston Scientific) Arctic Front Advance Pro (AFA-Pro) (Medtronic), in patients with paroxysmal undergoing PVI. Methods results This multicentre prospective observational included 267 consecutive a first cryoablation procedure for (137 PolarX, 130 AFA-Pro). Kaplan-Meier curves log-rank test used recurrence both groups....
Background— Reperfusion during acute myocardial infarction remains the best treatment for reducing infarct size. Postconditioning, applied at onset of reperfusion, reduces both in animals and humans. The objective this study was to identify time delay apply postconditioning allowing preservation cardioprotection mouse myocardium. This is a major issue management patients. Methods Results— Mice were subjected 40 minutes ischemia 60 reperfusion (IR 60′ ). Postconditioning protocols...
The recent availability of the novel oral anticoagulants (NOACs) may have led to a change in anticoagulation regimens patients referred catheter ablation atrial fibrillation (AF). Preliminary data exist concerning dabigatran, but information regarding safety and efficacy rivaroxaban this setting is currently scarce. Of 556 consecutive eligible (age 61.0 ± 9.6; 74.6% men; 61.2% paroxysmal AF) undergoing AF our centre (October 2012 September 2013) enroled systematic standardized 30-day...
Pulmonary vein isolation is the mainstay of treatment in catheter ablation paroxysmal atrial fibrillation (AF). Cryoballoon has been introduced more recently than radiofrequency ablation, standard technique most centres. veins frequently display anatomical variants, which may compromise results cryoballoon ablation. We aimed to evaluate mid-term outcomes an unselected population with AF from viewpoint. Consecutive patients who underwent a first procedure or were enrolled this single-centre...
Background Outcomes of catheter ablation atrial fibrillation (AF) are variable and the predictors success require further elucidation since identification correctable risk factors could help to optimize therapy. We aimed assess impact body mass index (BMI) in overall safety efficacy AF, with emphasis on use cryoballoon novel oral anticoagulants. Methods Results There were 2497 consecutive patients undergoing AF 7 European high volume centers stratified according BMI (normal weight <25 kg/m2,...
Multiple groups have reported on the usefulness of ablating in atrial regions exhibiting abnormal electrograms during fibrillation (AF). Still, previous studies suggested that ablation outcomes are highly operator- and center-dependent. This study sought to evaluate a novel machine learning software algorithm named VX1 (Volta Medical), trained adjudicate multipolar electrogram dispersion. was prospective, multicentric, nonrandomized conducted assess feasibility generating dispersion maps. In...
Background: Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease, and sudden cardiac death represents an important mode in these patients. Data evaluating implantable cardioverter defibrillator (ICD) this patient population remain scarce. Methods: A Nationwide French Registry including all patients with tetralogy ICD was initiated 2010 by Institute Health Medical Research. The primary time to event end point from implantation first appropriate therapy. Secondary...
electroporation ◼ isosorbide dinitrate nitrates
AimsReal-time measurement of contact force (CF) during catheter ablation atrial fibrillation (AF) has been recently suggested to potentially impact procedural outcome. However, the role CF intensity on mid-term results using SmartTouch™ not investigated so far.
Real-time assessment of pulmonary vein (PV) disconnection is possible using an inner circular mapping catheter during cryoablation atrial fibrillation (AF). However, it has been recently demonstrated that such continuous monitoring may only be in <50% PVs. We hypothesized a stepwise approach, including pacing manoeuvres, could optimize real-time PV ablation. Single-centre, prospective observational study (NCT01843465) 34 consecutive eligible patients (128 PVs) undergoing first procedure...