A5088247085- Breast Cancer Treatment Studies
- Advanced Radiotherapy Techniques
- Congenital Diaphragmatic Hernia Studies
- Maternal and Perinatal Health Interventions
- Pregnancy and preeclampsia studies
- Cancer Cells and Metastasis
- Neonatal Respiratory Health Research
- Uterine Myomas and Treatments
- Breast Lesions and Carcinomas
- Cancer Treatment and Pharmacology
- Maternal and fetal healthcare
- Congenital Anomalies and Fetal Surgery
- Pregnancy-related medical research
- Advances in Oncology and Radiotherapy
- Pelvic floor disorders treatments
- Endometriosis Research and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Reproductive Biology and Fertility
- Gynecological conditions and treatments
University Hospital Heidelberg
2016-2025
University Medical Centre Mannheim
2016-2025
Heidelberg University
2016-2025
Olgahospital
2011-2024
Klinik für Frauenheilkunde
2013-2024
Frauenklinik Heidelberg
2012-2022
Medizinische Fakultät Mannheim
2017-2022
Leopoldina Krankenhaus Schweinfurt
2020
Universitäts Frauenklinik
2003-2018
University of Mannheim
2010-2018
What is the success rate in terms of ovarian activity (menstrual cycles) as well pregnancy and delivery rates 1 year after orthotopic transplantations conducted a three-country network? In 49 women with follow-up >1 transplantation, ovaries were active 67% cases 33 25%, respectively. Cryopreservation tissue advance cytotoxic therapies later transplantation being performed increasingly often, total have been described case series. However, published series not allowed either more detailed...
Abstract Objective To determine whether risk adapted intraoperative radiotherapy, delivered as a single dose during lumpectomy, can effectively replace postoperative whole breast external beam radiotherapy for early cancer. Design Prospective, open label, randomised controlled clinical trial. Setting 32 centres in 10 countries the United Kingdom, Europe, Australia, States, and Canada. Participants 2298 women aged 45 years older with invasive ductal carcinoma up to 3.5 cm size, cN0-N1,...
Article27 November 2017Open Access Transparent process Screening drug effects in patient-derived cancer cells links organoid responses to genome alterations Julia Jabs orcid.org/0000-0002-4915-9966 Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany for Quantitative Analysis Molecular and Cellular Biosystems (BioQuant), University Department Bioinformatics Functional Genomics, Institute Pharmacy Biotechnology (IPMB) BioQuant, Heidelberg...
Abstract Metastatic colonization relies on interactions between disseminated cancer cells and the microenvironment in secondary organs. Here, we show that breast evoke phenotypic changes lung fibroblasts, forming a supportive metastatic niche. Colonization of lungs confers an inflammatory phenotype metastasis-associated fibroblasts. Specifically, IL-1α IL-1β secreted by induce CXCL9 CXCL10 production fibroblasts via NF-κB signaling, fueling growth metastases. Notably, find chemokine receptor...
Post-rest contractile behavior of isolated myocardium indicates the capacity sarcoplasmic reticulum (SR) to store and release Ca2+. We investigated post-rest in muscle strips from nonfailing (NF) endstage failing (dilated cardiomyopathy [DCM]) human hearts. At a basal stimulation frequency 1 Hz, parameters first twitch after increasing rest intervals (2-240 s) were evaluated. In NF (n = 9), steady state tension was 13.7 +/- 1.8 mN/mm2. With intervals, continuously increased maximally 29.9...
ABSTRACT Objective To determine whether the amniotic fluid index (AFI) or single deepest vertical pocket (SDP) technique for estimating volume is superior predicting adverse pregnancy outcome. Methods This was a multicenter randomized controlled trial including 1052 pregnant women with term singleton across four hospitals in Germany. Women were assigned randomly, according to computer‐generated allocation sequence, AFI SDP measurement estimation of volume. Oligohydramnios defined as ≤ 5 cm...
Research Article6 September 2018Open Access Source DataTransparent process Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis Jacob Insua-Rodríguez Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany Division of Cells Cancer, German Cancer Center (DKFZ), Faculty Biosciences, University Search more papers by this author Maren Pein Tsunaki Hongu Department Physiological Chemistry...
<h3>Importance</h3> Conventional adjuvant radiotherapy for breast cancer given daily several weeks is onerous and expensive. Some patients may be obliged to choose a mastectomy instead, some forgo altogether. We proposed clinical trial test whether could safely limited the tumor bed. <h3>Objective</h3> To determine delayed second-procedure targeted intraoperative (TARGIT-IORT) noninferior whole-breast external beam (EBRT) in terms of local control. <h3>Design, Setting, Participants</h3> In...
Problem To date, a multiplicity of factors contributing to the establishment and progression successful pregnancy have been postulated. There is emerging evidence that decidual leukocytes could be decisive during pregnancy. Despite numerous investigations on immune cells in human early decidua, little known about physiological composition proportion various cell populations different phases In this study, we therefore analyzed dominant tissue samples derived from all Methods Single...
Early life stress (ELS) is associated with increased vulnerability for diseases in later life, including psychiatric disorders. Animal models and human studies suggest that this effect mediated by epigenetic mechanisms. In humans, to investigate the influence of ELS on phenotypes are limited inaccessibility living brain tissue. Due tissue-specific nature signatures, it impossible determine whether induced changes accessible peripheral cells, example, blood lymphocytes, reflect brain. To...
Chemotherapy resistance resulting in incomplete pathologic response is associated with high risk of metastasis and early relapse breast cancer. The aim this study was to identify evaluate biomarkers treatment-resistant tumor cells. We performed a cell surface marker screen triple-negative cancer patient-derived xenograft models treated standard care genotoxic chemotherapy. Global expression profiling used further characterize the identified subpopulations. High sialyl-glycolipid...
Breast cancer (BC) patients often ask for a healthy diet. Here, we investigated standard diet (SD), low carb (LCD), and ketogenic (KD) BC during the rehabilitation phase. KOLIBRI was an open-label non-randomized one-site nutritional intervention trial, combining inpatient outpatient phases 20 weeks. Female (n = 152; mean age 51.7 years) could select their Data collected were: Quality of life (QoL), spiroergometry, body composition, blood parameters. In total 30, 92, 30 started KD, LCD, SD,...
Congenital diaphragmatic hernia (CDH) is a severe neonatal anomaly. The aim of this study was to evaluate the frequency and types malformations associated with CDH. outcome compared that in newborns CDH alone. included 362 fetuses at single national center for Associated chromosomal aberrations were noted prenatally postnatally. assessed relative use extracorporeal membrane oxygenation (ECMO) mortality rate. At least one malformation diagnosed 143 cases (39.5%). Altogether, 272 found. Only...
Cigarette smoking has severe adverse health consequences in adults and the offspring of mothers who smoke during pregnancy. One most widely reported effects pregnancy is reduced birth weight which turn associated with chronic disease adulthood. Epigenome-wide association studies have revealed that smokers show a characteristic "smoking methylation pattern", recent authors proposed DNA mediates impact maternal on weight. The aims present study were to replicate previous reports effect weight,...