A5102008507- Bioinformatics and Genomic Networks
- Animal Nutrition and Physiology
- Genetic and phenotypic traits in livestock
- Epigenetics and DNA Methylation
- Genetic Mapping and Diversity in Plants and Animals
- Pancreatic and Hepatic Oncology Research
- Adipose Tissue and Metabolism
- Genetic Associations and Epidemiology
- RNA Research and Splicing
- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Cancer-related gene regulation
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Antioxidant Activity and Oxidative Stress
- Cancer Mechanisms and Therapy
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive tract infections research
- Genetic Syndromes and Imprinting
- Clostridium difficile and Clostridium perfringens research
Longyan University
2014-2025
University of Hawaiʻi at Mānoa
2020-2025
University of Hawaii System
2020-2025
University of Hawaii Cancer Center
2020-2025
Institute of Animal Sciences
2013-2018
Chinese Academy of Agricultural Sciences
2013-2018
Education Department of Heilongjiang Province
2013
Qiqihar University
2013
Yangzhou University
2013
Northeast Agricultural University
2013
Abstract It remains elusive whether some of the associations identified in genome-wide association studies prostate cancer (PrCa) may be due to regulatory effects genetic variants on CpG sites, which further influence expression PrCa target genes. To search for sites associated with risk, here we establish models predict methylation (N = 1,595) and conduct analyses risk (79,194 cases 61,112 controls). We identify 759 showing an association, including 15 located at novel loci. Among those 42...
Body composition and meat quality traits are important economic of chickens. The development high-throughput genotyping platforms relevant statistical methods have enabled genome-wide association studies in In order to identify molecular markers candidate genes associated with body traits, were conducted using the Illumina 60 K SNP Beadchip genotype 724 Beijing-You For each bird, a total 16 measured, including carcass weight (CW), eviscerated (EW), dressing percentage, breast muscle (BrW)...
Abstract Background Meat quality is an important economic trait in chickens. To identify loci and genes associated with meat traits, we conducted a genome-wide association study (GWAS) of F2 populations derived from local Chinese breed (Beijing-You chickens) commercial fast-growing broiler line (Cobb-Vantress). Results In the present study, 33 signals were detected compressed mixed linear model (MLM) for 10 traits: dry matter breast muscle (DM Br ), thigh Th intramuscular fat content (IMF...
Autism spectrum disorder (ASD) is a neurodevelopmental with deficits in social communication ability and repetitive behavior. The pathophysiological events involved the brain of this complex disease are still unclear.In study, we aimed to profile gene expression signatures cortex ASD patients, by using two publicly available RNA-seq studies, order discover new ASD-related genes.We detected 1567 differentially expressed genes (DEGs) meta-analysis, where 1194 were upregulated 373 downregulated...
Abstract Background Genome-wide association studies (GWAS) have identified over 56 susceptibility loci associated with Alzheimer’s disease (AD), but the genes responsible for these associations remain largely unknown. Methods We performed a large transcriptome-wide study (TWAS) leveraging modified UTMOST (Unified Test MOlecular SignaTures) prediction models of ten brain tissues that are potentially related to AD discover novel genetic and putative target in 71,880 (proxy) cases 383,378...
Abstract Alzheimer disease (AD) is a common neurodegenerative with late onset. It critical to identify novel blood-based DNA methylation biomarkers better understand the extent of molecular pathways affected in AD. Two sets blood genetic prediction models developed using different reference panels and modelling strategies were leveraged evaluate associations genetically predicted levels AD risk 111,326 (46,828 proxy) cases 677,663 controls. A total 1,168 cytosine-phosphate-guanine (CpG)...
Egg production is an important economic trait in layer ducks and understanding the genetics basis for their breeding. In this study, a genome-wide association study (GWAS) egg traits 303 female Longyan Shan-ma was performed based on genotyping-by-sequencing strategy. Sixty-two single nucleotide polymorphisms (SNPs) associated with weight were identified (P < 9.48 × 10
Abstract Pancreatic cancer is among the most well-characterized types, yet a large proportion of heritability pancreatic risk remains unclear. Here, we performed transcriptome-wide association study to systematically investigate associations between genetically predicted gene expression in normal pancreas tissue and risk. Using data from 305 subjects mostly European descent Genotype-Tissue Expression Project, built comprehensive genetic models predict expression, modifying UTMOST (unified...
Background: To reveal candidate genes and the molecular genetic mechanism underlying primary feather color trait in ducks, a genome-wide association study (GWAS) for was performed based on genotyping-by-sequencing (GBS) technology native Chinese female duck, Longyan Shan-ma ducks. Methods: Blood genomic DNA from 314 duck were genotyped using GBS technology. A GWAS with genome variations an univariate linear mixed model all SNPs autosomes. Results: Seven significant single nucleotide...
Alzheimer's disease (AD) is a common neurodegenerative in aging individuals. Alternative splicing reported to be relevant AD development while their roles etiology of remain largely elusive. We performed comprehensive transcriptome-wide association study (spTWAS) using intronic excision expression genetic prediction models 12 brain tissues developed through three modelling strategies, identify candidate susceptibility introns for risk. A total 111,326 (46,828 proxy) cases and 677,663...
The gel properties of egg white are important functional traits poultry eggs, yet limited research exists on the utilization whites from local Chinese duck breeds. This study systematically investigated properties, ultrastructure, and proteomics Putian Black Duck (PTEW) Liancheng White (LCEW). Results showed that PTEW gels exhibited superior texture (hardness, 20.6% higher than LCEW; gumminess, 11.3% higher; chewiness, 11.1% cohesiveness, 7.1% higher) water holding capacity (7.7% higher). In...
ABSTRACT Objective A number of susceptibility genes in prostate tissue have been identified to be associated with cancer (PCa) risk. However, the reported based on assessing could not fully explain PCa genetic susceptibility. It is believed that functioning immune system may fill gap some missing heritability. Methods To study potential acting such pathways, we performed a transcriptome‐wide association (TWAS) 79,194 cases and 61,112 control European ancestry by using three sets gene...
Peroxisome proliferator-activated receptor γ is a master regulator of adipocyte differentiation and function. Expression PPARγ in mammals regulated by DNA methylation; however, it currently unknown whether chicken expression methylation. To enhance our understanding molecular mechanisms underlying adipose tissue development adipogenesis, we investigated the promoter methylation status gene Northeast Agricultural University broiler lines divergently selected for abdominal fat content...
Polydactyly occurs in some chicken breeds, but the molecular mechanism remains incompletely understood. Combined genome-wide linkage analysis and association study (GWAS) for polydactyly helps identify loci or candidate genes trait potentially provides further mechanistic understanding of this phenotype chickens perhaps other species. The GWAS was conducted using an F2 population derived from Beijing-You commercial broilers. results identified two QTLs through seven single-nucleotide...
Physical appearance traits, such as feather-crested head, comb size and type, beard, wattles size, feathered feet, are used to distinguish between breeds of chicken also may be associated with economic traits. In this study, a genome-wide linkage analysis was identify candidate regions genes for physical traits potentially provide further knowledge the molecular mechanisms that underlie these The conducted an F2 population derived from Beijing-You chickens commercial broiler line....
Abstract A large proportion of heritability for prostate cancer risk remains unknown. Transcriptome‐wide association study combined with validation comparing overall levels will help to identify candidate genes potentially playing a role in development. Using data from the Genotype‐Tissue Expression Project, we built genetic models predict normal tissue gene expression using statistical framework PrediXcan, modified version unified test molecular signatures and Joint‐Tissue Imputation. We...
Alzheimer's disease (ad) adversely affects the health, quality of life and independence patients. There is a critical need to identify novel blood gene biomarkers for ad risk assessment. We performed transcriptome-wide association study biomarker candidates risk. leveraged two sets expression prediction models developed using different reference panels modeling strategies. By applying meta-GWAS including 71 880 (proxy) cases 383 378 controls, we identified significant associations...
In this study, signaling pathways and key differentially expressed genes (DEGs) involved in lipid metabolism muscle fat tissues were investigated. Muscle abdominal obtained from 35-day-old female broilers for RNA sequencing. DEGs between identified. Gene ontology (GO) Kyoto Encyclopedia of Genes Genomes pathway enrichment analyses performed. A total 6130 identified to be significantly enriched 365 GO terms, most which biological processes, cellular components, molecular functions tissues....
Vitamin E is an essential micronutrient for animals. The aim of this study was to determine the effect vitamin on intramuscular fat (IMF) deposition and transcriptome profile pectoral muscle in broiler chickens. Arbor Acres chickens were divided into five treatment groups fed a basal diet supplemented with 0, 20, 50, 75, 100 IU/kg dietary DL-α-tocopheryl acetate (vitamin E), respectively. Body weight, carcass performance, IMF content recorded. Transcriptome profiles muscles 35-day-old...
Abstract Egg production traits are economically important in laying ducks. Genetic molecular mechanisms and candidate genes underlying these remain unclear. In this study, whole genome variants were identified through whole-genome resequencing using three high-egg producing (HEN) low-egg (LEN) The gene ontology (GO) terms Kyoto Encyclopedia of Genes Genome (KEGG) pathways for the common differential between HEN LEN ducks determined. Frizzled class receptor 6 ( FZD6 ) was further genotyped...
The associations between polymorphisms of five genes, calpain 1 (CAPN1), follicle stimulating hormone beta (FSHB), receptor (FSHR), peroxisome proliferator-activated gamma (PPARG), and retinol binding protein 7 (RBP7), live weight, carcass composition, meat-quality traits were estimated from two meat-type chickens lines (n=311). Except for the variants FSHR gene, 11 SNPs other four genes diplotypes PPARG associated with one or more excluding shear factor (SF). SNP C31566680T CAPN1 gene was...
The objective of this study was to compare the expression adenosine monophosphate-activated protein kinase ( AMPK) and its relation rates lipogenesis in muscle fast (Arbor Acres, AA chickens)-and slow (Bei-Jing-You, BJY chickens)-growing chicken strains. Twelve birds for each strain were selected slaughtered at 8 weeks age chickens week 8, 16 chickens. amount intramuscular fat (IMF) content, AMPK subunits key regulators thigh breast tissue determined. Results showed that content IMF...