A5026365030- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Genetic Associations and Epidemiology
- Prostate Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
University of the Aegean
2019-2021
Abstract A large proportion of heritability for prostate cancer risk remains unknown. Transcriptome‐wide association study combined with validation comparing overall levels will help to identify candidate genes potentially playing a role in development. Using data from the Genotype‐Tissue Expression Project, we built genetic models predict normal tissue gene expression using statistical framework PrediXcan, modified version unified test molecular signatures and Joint‐Tissue Imputation. We...
In our previous study, we developed a genome-wide DNA methylation model for the diagnosis of prostate cancer, and pointed out that considerable average error is associated with current method which predicated on pathological assessment biopsied tissue. this utilized whole exome transcriptome RNA-sequencing (RNA-seq) data were derived from 468 tumor samples 51 normal prostatic tissue, analyzed over 20,000 genes per sample. We able to develop mathematical classified tissue versus high...