A5058823505- Salivary Gland Disorders and Functions
- Traditional Chinese Medicine Studies
- Natural product bioactivities and synthesis
- Flavonoids in Medical Research
- NF-κB Signaling Pathways
- Olfactory and Sensory Function Studies
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Tracheal and airway disorders
- Atherosclerosis and Cardiovascular Diseases
- Growth Hormone and Insulin-like Growth Factors
- Systemic Lupus Erythematosus Research
- Hepatitis C virus research
- Exercise and Physiological Responses
- Pharmacological Effects of Natural Compounds
- Healthcare and Venom Research
- Gut microbiota and health
- Oral microbiology and periodontitis research
- interferon and immune responses
- Hepatocellular Carcinoma Treatment and Prognosis
- Chemokine receptors and signaling
- Organ and Tissue Transplantation Research
- Cell death mechanisms and regulation
- Pancreatic function and diabetes
- Hepatitis B Virus Studies
First Affiliated Hospital Zhejiang University
2009-2025
Zhejiang University
2016-2025
Zhejiang Chinese Medical University
2008-2025
First Hospital of China Medical University
2010-2017
Hangzhou Dianzi University
2017
China Medical University
2010-2017
Xian Yang Central Hospital
2013
Boxing People's Hospital
2013
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by sustained fibrotic lesions. Orally administered drugs usually fail to efficiently penetrate the tissue and reach lesions, resulting in low treatment efficiency. Luteolin (Lut) natural flavonoid, active metabolites of which possess antioxidant, anti‐inflammatory, anti‐fibrotic, anti‐apoptotic properties. In this study, nano‐formulation developed loading Lut into hyaluronidase...
Malignant esophageal mediastinal fistula is a severe complication that occurs in both the advanced stages of cancer and after radiotherapy for cancer. Esophageal very susceptible to complications such as mediastinitis abscess, resulting significantly elevated mortality rate patients. We reported rare case immunotherapy non-small cell lung (NSCLC). A 74-year-old male patient with NSCLC was hospitalized July 2023. About one week Tislelizumab immunotherapy, suddenly developed high fever...
This study aimed to construct a diagnostic risk model for Bipolar Disorder (BD) using inflammation-related genes (IRGs) and explore the role of immune cell infiltration in BD pathogenesis. datasets (GSE23848, GSE124326, GSE39653, GSE46449) were retrieved from Gene Expression Omnibus (GEO) database. Differentially expressed (DEGs) identified edgeR package. The intersection DEGs IRGs was defined as differentially IRGs. A LASSO regression used identify optimal biomarkers, which then utilized...
Objective: In this retrospective analysis, total glucosides of paeony (TGP) were compared with hydroxychloroquine (HCQ) in the treatment patients primary Sjogren’s syndrome (pSS). Methods: retrospectively 157 SS treated at First Affiliated Hospital Zhejiang University School Medicine hospital between January 2020 and December 2023 included. The analysis included flow rates saliva tears before after control group observation group, as well levels white blood cells (WB), hemoglobin (Hb),...
Primary Sjogren's syndrome (pSS) is a slowly progressive, systemic autoimmune disorder characterized by gradual lymphocytic infiltration of exocrine glands. However, the spatially profiling immune microenvironment in pSS largely unclear, limiting understanding complex interplay among cells within microenvironment. Based on imaging mass cytometry (IMC) analysis clinical samples, we first revealed that labial salivary gland (LSG) comprised epithelial, and stromal cells, epithelial was main...
Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis and high mortality. This study aimed to explore the oncogenic mechanisms of TRAF5 in HCC provide novel therapeutic strategy for HCC.Human cell lines (HepG2, HuH7, SMMC-LM3, Hep3B), normal adult liver epithelial cells (THLE-2), human embryonic kidney (HEK293T) were utilized. Cell transfection was performed functional investigation. qRT-PCR western blotting used detect mRNA expression TRAF5, LTBR, NF-κB protein...
Abstract Purpose To investigate the effect of total glucoside paeony (TGP) on gut microbiota in NOD mice with Sjögren’s syndrome (SS), using high-throughput sequencing 16SrRNA gene. Methods Twenty-four were randomly assigned to 4 groups (n = 6 per group): sham group receiving deionized water (0.4 ml), hydroxychloroquin TGP and + 0.4 ml hydroxychloroquin. Balb/c 6) used as a control group. After intragastric injection drugs for 8 weeks, feces collected Results The gene resulted 3686 OTUs, 10...
The activated NF- κ B signaling pathway plays an important role in pathogenesis of primary Sjögren’s syndrome (pSS). inhibitor (I B) kinase (IKK) family such as IKK α , β γ and ε is required for this signaling. Our aim was to investigate the / patients with untreated pSS. In minor salivary glands from pSS patients, phosphorylated (pIKK ), pI pNF- p65 (p-p65) were highly expressed ductal epithelium infiltrating mononuclear cells by immunohistochemistry, compared healthy individuals. pIKK both...
The present study aimed to investigate the molecular mechanisms underlying effects of total glucosides peony (TGP) in treatment Sjögren's syndrome (SS). A 40 mice with SS were evenly assigned into four groups, including: Control group; TGP group, receiving 1 mg daily; hydroxychloroquine (HCQ) 0.25 HCQ and a combined daily. After 8 weeks, quantitative polymerase chain reaction an enzyme-linked immunosorbent assay used detect levels interferon-γ (IFN-γ), interleukin-4 (IL-4), Fas FasL each...
Objective: To assess the necessity of prophylactic antibiotic therapy in HCC patients undergoing transcatheter arterial chemoembolization (TACE).
In this study, ultra-high performance liquid chromatography-linear ion trap/electrostatic field orbit trap combined-type mass spectrometry(UPLC-LTQ-Orbitrap-MS) was used to analyze the main active components of Huangqi Guizhi Wuwu Decoction(HQGZ). A total 50 were identified from HQGZ and 108 potential targets related treatment rheumatoid arthritis retrieved based on network pharmacology, including 87 key targets, followed by Gene Ontology(GO) term enrichment Kyoto Encyclopedia Genes...