A5039578808- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Antibiotic Resistance in Bacteria
- Escherichia coli research studies
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Urinary Tract Infections Management
- Bacterial Identification and Susceptibility Testing
- Virology and Viral Diseases
- Clostridium difficile and Clostridium perfringens research
- Bacteriophages and microbial interactions
- Antimicrobial Resistance in Staphylococcus
- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Bacterial biofilms and quorum sensing
- Vaccine Coverage and Hesitancy
- Advancements in Transdermal Drug Delivery
- Animal Virus Infections Studies
- Vibrio bacteria research studies
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Bacterial Genetics and Biotechnology
- Malaria Research and Control
Kolon Life Science (South Korea)
2016-2025
Morristown Medical Center
2012-2023
Rutgers, The State University of New Jersey
2022
St. George's School
2017
Primary Source
2015
University of Pennsylvania
2001-2012
Philadelphia VA Medical Center
2001-2011
California University of Pennsylvania
2011
Biology of Infection
2009
Office of Infectious Diseases
2004-2008
Small-colony variants (SCVs) of Staphylococcus aureus were cultured from five patients with persistent and relapsing infections. All SCV strains nonhemolytic nonpigmented grew very slowly on routine culture media in an ambient atmosphere. In several instances, these phenotypic characteristics led to the initial misidentification organisms clinical microbiology laboratory. four available for further analysis shown be auxotrophs that reverted normal growth morphology presence menadione, hemin,...
Soon after methicillin was introduced into clinical practice in the early 1960s, resistant strains of Staphylococcus aureus (MRSA) appeared, bearing a newly acquired resistance gene, mecA , that encodes penicillin binding protein, PBP2a. MRSA have spread throughout world, and an investigation clonality 472 isolates by DNA hybridization performed. All could be divided six temporally ordered patterns, three these were subdivided chromomosomal transposon Tn 554 . Each pattern occurred...
Although Zika virus (ZIKV) infection is typically self-limiting, other associated complications such as congenital birth defects and the Guillain-Barré syndrome are well described. There no approved vaccines against ZIKV infection.
Disseminated infection with organisms of the Mycobacterium avium complex (MAC) is a common complication AIDS in United States and other developing countries, but it rare or absent sub-Saharan Africa. To assess comparative likelihood exposure to MAC these geographic areas, we used standard protocol culture 91 water samples from environmental sites piped supply systems States, Finland, Zaire, Kenya. was isolated all areas 22 (24%) samples. Isolation rates were 13 47 (28%) for 9 44 (20%)...
Abstract Significant concerns have been raised owing to the rapid global spread of infection and disease caused by mosquito-borne Zika virus (ZIKV). Recent studies suggest that ZIKV can also be transmitted sexually, further increasing exposure risk for this virus. Associated with is a dramatic increase in cases microcephaly additional congenital abnormalities infants ZIKV-infected mothers, as well rise occurrence Guillain Barre’ syndrome infected adults. Importantly, there are no licensed...
Abstract Background Nonlive vaccine approaches that are simple to deliver and stable at room temperature or 2–8°C could be advantageous in controlling future Ebola virus (EBOV) outbreaks. Using an immunopotent DNA generates protection from lethal EBOV challenge small animals nonhuman primates, we performed a clinical study evaluate both intramuscular (IM) novel intradermal (ID) delivery. Methods Two candidates (INO-4201 INO-4202) targeting the glycoprotein (GP) were evaluated for safety,...
Abstract Zika virus (ZIKV) is an emerging pathogen causally associated with serious sequelae in fetuses, inducing fetal microcephaly and other neurodevelopment defects. ZIKV primarily transmitted by mosquitoes, but can persist human semen sperm, sexual transmission has been documented. Moreover, exposure of type-I interferon knockout mice to results severe damage the testes, epididymis sperm. Candidate vaccines have shown protective efficacy preclinical studies carried out animal models,...
Journal Article Genetic Diversity among Strains of Mycobacterium avium Causing Monoclonal and Polyclonal Bacteremia in Patients with AIDS Get access Robert D. Arbeit, Arbeit Reprints or correspondence: Dr. Research Service (151 ), VA Medical Center, 150 S. Huntington Ave., Boston, MA 02130. Search for other works by this author on: Oxford Academic PubMed Google Scholar Alex Slutsky, Slutsky Thomas W. Barber, Barber Joel N. Maslow, Maslow Sandra Niemczyk, Niemczyk Joseph O. Falkinham, III,...
Type 1 fimbriae are heteropolymeric surface organelles responsible for the D-mannose-sensitive (MS) adhesion of Escherichia coli. We recently reported that variation receptor specificity type can result solely from minor alterations in structure gene FimH adhesin subunit. To further study relationship between allelic fimH and adhesive properties fimbriae, genes five additional strains were cloned used to complement deletion E. coli KB18. When parental recombinant tested immobilized mannan, a...
Although the incidence of severe fever with thrombocytopenia syndrome virus (SFTSV) infection has increased from its discovery a mortality rate 10-20%, no effective vaccines are currently available. Here we describe development SFTSV DNA vaccine, immunogenicity, and protective efficacy. Vaccine candidates induce both neutralizing antibody response multifunctional SFTSV-specific T cell in mice ferrets. When vaccine efficacy is investigated aged-ferrets that recapitulate fatal clinical...
ABSTRACT The phylogenetic distributions of multiple putative virulence factors (VFs) and papA (P fimbrial structural subunit) alleles among 182 Escherichia coli blood isolates from patients with diverse-source bacteremia were defined. Phylogenetic correspondence these strains, the E. Reference (ECOR) collection, other collections extraintestinal pathogenic (ExPEC) was assessed. Although group B2 predominated, exhibited greatest concentration individual VFs, contained largest number familiar...
Journal Article Endemic Nosocomial Transmission of Staphylococcus epidermidis Bacteremia Isolates in a Neonatal Intensive Care Unit over 1O Years Get access Johannes Huebner, Huebner Search for other works by this author on: Oxford Academic PubMed Google Scholar Gerald B. Pier, Pier Joel N. Maslow, Maslow Eugene Muller, Muller Hiroyuki Shiro, Shiro Michelle Parent, Parent Andrea Kropec, Kropec Robert D. Arbeit, Arbeit Donald A. Goldmann Reprints or correspondence: Dr. Goldmann, Division...
Electrospray deposition (ESD) is a promising technique for depositing micro-/nano-scale droplets and particles with high quality repeatability. It particularly attractive surface coating of costly delicate biomaterials bioactive compounds. While efficiency ESD has only been successfully demonstrated spraying surfaces larger than the spray plume, this work extends its utility to smaller surfaces. shown that by architecting local "charge landscape", coatings plume size can be achieved....
The deaths of two Asian elephants (Elephas maximus) in August 1996 led the United States Department Agriculture to require testing and treatment for tuberculosis. From September 1999. Mycobacterium tuberculosis infection was confirmed by culture 12 118 six herds. Eight diagnoses were made antemortem on basis isolation M. trunk wash samples; remainder (including initial two) diagnosed postmortem. We present case histories, epidemiologic characteristics, diagnostic test results, therapeutic...
Associations of virulence genotype and phylogenetic background with epidemiological factors (primary source bacteremia, host compromise status, hospital versus community origin) were assessed among 182 Escherichia coli blood isolates from adults diverse-source bacteremia in comparison fecal controls the E. Reference collection. A continuum was found, urinary pulmonary (high virulence), through "other" or unknown (intermediate to (low a corresponding graded distribution predominantly group B2...
The recent discovery of a geographically dispersed clonal group Escherichia coli O4:H5 that includes prototypic uropathogenic strain J96 prompted us to determine the prevalence J96-like strains within serogroup O4 and further assess characteristics such strains. We used O:K:H;F serotyping, PCR-based genomic fingerprinting, pulsed-field gel electrophoresis (PFGE), multilocus enzyme (MLEE), PCR detection three papG alleles cytotoxic necrotizing factor 1 (cnf1) aerobactin (aer) gene sequences...
Invasive infection with organisms of the Mycobacterium avium complex (MAC) is common among patients advanced human immunodeficiency virus infection. In previous studies, we analyzed multiple individual colonies MAC isolated from specimens obtained at same time and observed that 14 to 20% are simultaneously infected more than one strain. this study, examined sequential isolates 12 AIDS who had two or available clinical collected 1 week apart; intervals between first last ranged 8 192 (median,...
Suction-mediated cutaneous DNA uptake yielded high in vivo efficiency and thus provides an alternative transfection platform.
We highlight the significant progress in developing DNA vaccines during SARS-CoV-2 pandemic. Specifically, we provide a comprehensive review of that have progressed to Phase 2 testing or beyond, including those received authorization for use. advantages with regard rapidity production, thermostability, safety profile, and cellular immune responses. Based on user needs cost, compare three devices used clinical trials. Of devices, GeneDerm suction device offers numerous benefits, particularly...
The clonal relationships among 187 bloodstream isolates of Escherichia coli from 179 patients at Boston, Mass., Long Beach, Calif., and Nairobi, Kenya, were determined by multilocus enzyme electrophoresis (MLEE), analysis polymorphisms associated with the ribosomal operon (ribotyping), serotyping. MLEE based on 20 enzymes resolved 101 electrophoretic types (ETs), forming five clusters; ribotyping 56 distinct patterns concordant MLEE. each study site formed a genetically diverse group...
Abstract Background Antibiotic resistance in the long-term-care facility (LTCF) setting is of increasing concern due to both increased morbidity and mortality related infections this debilitated population potential for transfer resistant organisms other healthcare settings. Longitudinal trends antibiotic LTCFs have not been well described. Design: Correlational longitudinal survey study. Setting: Four Pennsylvania. Subjects: All clinical cultures residents participating (700 total beds)...