A5080289075- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Multiple Myeloma Research and Treatments
- Dermatology and Skin Diseases
- Salmonella and Campylobacter epidemiology
- Vector-Borne Animal Diseases
- vaccines and immunoinformatics approaches
- Viral Infections and Vectors
- Chemokine receptors and signaling
- Advancements in Transdermal Drug Delivery
- Transgenic Plants and Applications
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Signaling Pathways in Disease
- Yersinia bacterium, plague, ectoparasites research
- Listeria monocytogenes in Food Safety
- Immune Response and Inflammation
- Cardiac Fibrosis and Remodeling
- Angiogenesis and VEGF in Cancer
- Viral Infections and Outbreaks Research
- Microbial Metabolites in Food Biotechnology
Yonsei University
2024-2025
Dong-A University
2024
Seoul National University
2022-2023
Cell Biotech (South Korea)
2023
Korea Advanced Institute of Science and Technology
2017-2022
Shanghai Cell Therapy Research Institute
2022
Bio-Medical Science (South Korea)
2017-2019
We assessed the safety and immunogenicity of two recombinant DNA vaccines for COVID-19: GX-19 containing plasmid encoding SARS-CoV-2 spike protein, GX-19N receptor-binding domain (RBD) foldon, nucleocapsid protein.Two open-label non-randomised phase 1 trials, one other were done at hospitals in South Korea. enrolled healthy adults aged 19-49 years trial 19-54 trial. Participants who tested positive by serological testing excluded. At 4-week intervals, participants received vaccine doses...
Although the incidence of severe fever with thrombocytopenia syndrome virus (SFTSV) infection has increased from its discovery a mortality rate 10-20%, no effective vaccines are currently available. Here we describe development SFTSV DNA vaccine, immunogenicity, and protective efficacy. Vaccine candidates induce both neutralizing antibody response multifunctional SFTSV-specific T cell in mice ferrets. When vaccine efficacy is investigated aged-ferrets that recapitulate fatal clinical...
Detecting and identifying the origins of foodborne pathogen outbreaks is a challenging. The Next-Generation Sequencing (NGS) panel method offers potential solution by enabling efficient screening identification various bacteria in one reaction. In this study, new NGS primer sets that target 18 specific virulence factor genes from six pathogens (Bacillus cereus, Yersinia enterocolitica, Staphylococcus aureus, Vibrio cholerae, parahaemolyticus, vulnificus) were developed optimized. validated...
Recent animal studies showed T cells have a direct pathogenic role in the development of heart failure (HF). However, which subsets contribute to human HF pathogenesis and progression remains unclear. We characterized immunologic properties various their clinical implications HF. Thirty-eight consecutive patients with newly diagnosed acute (21 males, mean age 66 ± 16 years) 38 healthy control subjects 62 12 were enrolled. found that pro-inflammatory mediators, including CRP, IL-6 IP-10...
There is insufficient data on the longevity of immunity acquired after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
The prognosis of non-Hodgkin lymphoma (NHL) remains poor, with an unmet need for novel therapies. MG4101, ex vivo-expanded allogeneic natural killer (NK) cell, can enhance rituximab antibody-dependent cytotoxicity in relapsed/refractory (r/r) B cell lymphoma. This study assessed the safety and efficacy MG4101 plus patients r/r NHL. Patients received escalating doses i.v. every 2 weeks. IL-2 was administered s.c. after treatment. Fludarabine cyclophosphamide before treatment cycles 1, 3, 5. A...
Background Major histocompatibility complex (MHC) class I chain-related protein (MIC) is a stress-induced ligand released from multiple myeloma (MM) cells during progression, and soluble MIC impairs natural killer group 2D (NKG2D) activating receptor-mediated recognition function of (NK) cells. However, whether clearing with monoclonal antibody (mAb) can restore NK cell activity MM patients remains undetermined. Methods We analyzed The Cancer Genome Atlas (TCGA) Multiple Myeloma Research...
Eriocitrin, a flavanone found in peppermint and citrus fruits, is known to possess many physiological activities. However, the anti-angiogenic effects of eriocitrin are yet be fully elucidated. Therefore, objective this research was explore both vitro vivo as well its underlying mechanism. Anti-angiogenic were evaluated utilizing models angiogenesis, including inhibition tube formation, induction apoptosis human umbilical vein endothelial cells (HUVECs). A chorioallantoic membrane (CAM)...
Sourdough bread fermented with yeast and lactic acid bacteria (LAB) is thought to have various beneficial health effects. However, its effects were not fully evaluated in vivo mouse model. To evaluate these vivo, a feeding study microbiome analysis of white containing 40% sourdough (WBS) yeast-leavened (WB) performed. Although feed consumption body weight increased WBS, the glycemic index was reduced, suggesting diabetes-lowering effect, probably due presence dietary fiber short-chain fatty...
Herpes zoster (HZ), or shingles, is caused by the reactivation of latent varicella-zoster virus (VZV) from sensory ganglia when VZV-specific T-cell immunity decreased because aging immunosuppression.In present study, we developed HZ DNA vaccine candidates encoding VZV proteins and cytokine adjuvants, such as IL-7 IL-33.We immunized C57BL/6 mice with plasmids glycoprotein E (gE), immediate early (IE) 63, IE62 found that robust protein-specific responses were elicited...
Background: There is insufficient data on the longevity of immunity acquired following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to evaluate duration SARS-CoV-2-specific humoral and cellular according clinical severity disease 2019 (COVID-19).Methods: Convalescent blood was collected prospectively from 97 patients who had recovered COVID-19. The level SARS-CoV-2 measured using anti-SARS-CoV-2 nucleocapsid immunoglobulin G (IgG) assay plaque reduction...
Abstract Background We investigated the safety and immunogenicity of two recombinant COVID-19 DNA vaccine candidates in first-in-human trials. GX-19 contains plasmid encoding SARS-CoV-2 spike protein, GX-19N receptor binding domain (RBD) foldon nucleocapsid protein (NP) as well protein. Methods Two open-label phase 1 trials were performed healthy adults aged 19–55 years. trial participants received injections (1·5 mg or 3·0 mg, 1:1 ratio) four weeks apart. Findings Between June 17 July 30...
Abstract Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging tick-borne infectious disease caused by the SFTS virus (SFTSV) belonging to Phenuiviridae family. The WHO lists SFTSV as one of most dangerous viral pathogens, and considers it likely cause wide epidemics in near future. incidence infection has increased from its discovery 2012 through 2018 mortality rate 10–20% major clinical symptoms are fever, vomiting, diarrhea, thrombocytopenia, leukopenia multiple organ...
Abstract Chronic pulmonary aspergillosis (CPA) is a severe disease caused by aspergillus fumigatus infection. However, immune responses in CPA patients remained to be elucidated. In humans, the CD4+Foxp3+regulatory T cell (Treg) population are classified into following three subsets based on their expression of CD45RA and Foxp3: CD45RA+Foxp3lo resting Treg cells (subset I), CD45RA−Foxp3high activated II), CD45RA−Foxp3locytokine-secreting non-suppressive III). present study, we investigated...
Background: MG4101, an ex vivo-expanded allogeneic natural killer cell line, can enhance rituximab antibody-dependent cellular cytotoxicity in a mouse xenograft model. This phase I trial assessed the safety and efficacy of MG4101 plus patients with relapsed/refractory B-cell non-Hodgkin lymphoma (r/r NHL).Methods: Patients received escalating doses intravenous every two weeks rituximab. IL-2 was administered subcutaneously at dose 1 × 106 IU/m2 per day, least h after MG4101. Fludarabine (20...
Abstract MG4101, an ex vivo -expanded allogeneic natural killer cell, can enhance rituximab antibody-dependent cytotoxicity in relapsed/refractory B-cell non-Hodgkin lymphoma (r/rNHL). Its safety and efficacy were assessed this phase I trial. Patients received escalating doses of intravenous MG4101 every 2 weeks plus rituximab. Interleukin-2 was administered subcutaneously after treatment. Fludarabine cyclophosphamide intravenously before cycles 1, 3, 5. A 3 + design used to determine the...