A5023827380- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Sepsis Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Antifungal resistance and susceptibility
- Infective Endocarditis Diagnosis and Management
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Cytomegalovirus and herpesvirus research
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Fungal Infections and Studies
- SARS-CoV-2 and COVID-19 Research
- Antibiotics Pharmacokinetics and Efficacy
- Nosocomial Infections in ICU
- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
- Infections and bacterial resistance
- Infectious Diseases and Tuberculosis
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
Yonsei University
2016-2025
Gangnam Severance Hospital
2013-2024
Chengdu University of Traditional Chinese Medicine
2024
Severance Hospital
2009-2023
Yonsei University Health System
2015-2022
Institute of Molecular Biology and Biophysics
2016
Harbin Medical University
2016
Second Affiliated Hospital of Harbin Medical University
2016
Christie's
2012
Zero to Three
2012
Sepsis, including severe sepsis and septic shock, is a major cause of morbidity mortality. Albumin C-reactive protein (CRP) are considered as good diagnostic markers for sepsis. Thus, initial CRP albumin levels were combined to ascertain their value an independent predictor 180-day mortality in patients with shock.We conducted retrospective cohort study involving 670 (>18 years old) who admitted the emergency department had received standardized resuscitation algorithm (early goal-directed...
Red blood cell distribution width (RDW) is known to be a predictor of severe morbidity and mortality in some chronic diseases such as congestive heart failure. However, our knowledge, little about RDW patients with Gram-negative bacteremia, major nosocomial cause intra-abdominal infections, urinary tract primary bacteremia. Therefore, we investigated whether an independent Clinical characteristics, laboratory parameters, outcomes 161 bacteremia from November 2010 March 2011 diagnosed at...
A novel severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) causing COVID-19 pandemic in humans, recently emerged and has exported more than 200 countries as a result of rapid spread. In this study, we have made an attempt to investigate the SARS-CoV-2 genome reported from 13 different countries, identification mutations major coronavirus proteins these genomes compared with SARS-CoV. These thirteen complete sequences showed high identity (>99%) each other, while they shared...
We assessed the safety and immunogenicity of two recombinant DNA vaccines for COVID-19: GX-19 containing plasmid encoding SARS-CoV-2 spike protein, GX-19N receptor-binding domain (RBD) foldon, nucleocapsid protein.Two open-label non-randomised phase 1 trials, one other were done at hospitals in South Korea. enrolled healthy adults aged 19-49 years trial 19-54 trial. Participants who tested positive by serological testing excluded. At 4-week intervals, participants received vaccine doses...
Abstract Background and Aims: Bacterial gastroenteritis has been known as a risk factor of irritable bowel syndrome (IBS). Several factors post‐infectious IBS (PI‐IBS) have documented. The aims this study were to verify the role bacterial in development for PI‐IBS. clinical course PI‐IBS was also investigated. Methods: We recruited 143 patients with shigellosis during its outbreak 113 controls. Both groups followed up 12 months. Bowel symptoms evaluated by use questionnaires at 3, 6 months...
To evaluate the effects of transfusions in patients with severe sepsis and septic shock on mortality.Propensity-matched analysis a prospective observational database (April 2005 to February 2009).Twenty-two medical surgical intensive care units 12 teaching hospitals Korea.One thousand fifty-four community-acquired shock.None.Of 1,054 patients, 407 (38.6%) received blood transfusion. The mean pretransfusion hemoglobin level was 7.7 ± 1.2 g/dL. Transfused had higher 28-day in-hospital...
Stenotrophomonas maltophilia is a nosocomial pathogen associated with high morbidity and mortality, particularly in immunocompromised or critically ill patients. In this study, we investigated the risk factors for mortality patients S. bacteremia. Retrospectively, medical records from all bacteremia between December 2005 2014 at Severance Hospital, 2000-bed tertiary care hospital Seoul, Korea, were reviewed. Analysis was performed to identify 28-day mortality. total, 142 enrolled study. The...
Stenotrophomonas maltophilia is an important nosocomial pathogen. This pathogen has intrinsic or acquired resistance to a number of antibiotics classes. Furthermore, infections have been associated with high mortality, mainly in immunocompromised patients. Accordingly, we conducted retrospective cohort study on the clinical data, microbiological characteristics, and outcomes patients S. (SM) bacteremia. A was at two tertiary care referral hospitals Seoul, South Korea. Data were collected...
Infection is a major cause of mortality in patients with systemic lupus erythematosus (SLE). This study describes infectious complications SLE and analyzes the risk factors for infection at time diagnosis during course case-control study. Of 110 enrolled, 42 (38%) had least 1 episode disease. The incidence disease was 4.4/100 patient-years (py) total follow-up duration 954 y. In multivariate analysis, independent predictors were an activity index (SLEDAI) > 12 (p = 0.01), C3 levels < 90...
Purpose: Over the last 30 years, Serratia marcescens (S. marcescens) has emerged as an important pathogen, and a common cause of nosocomial infections.The aim this study was to identify risk factors associated with mortality in patients S. bacteremia.Materials Methods: We performed retrospective cohort 98 who had one or more blood cultures positive for between January 2006 December 2012 tertiary care hospital Seoul, South Korea.Multiple were compared association 28-day all-cause...
University Hospitals in KoreaA prospective multicenter observational study was performed to investigate the epidemiology and outcomes of community-acquired severe sepsis septic shock.Subjects included 1,192 adult patients admitted 22 participating intensive care units (ICUs) 12 university hospitals Korean Sepsis Registry System from April, 2005 through February, 2009.Male accounted for 656 (55%) patients.Mean age 65.0 ± 14.2 yr.Septic shock developed 740 (62.1%) patients.Bacteremia present...
Purpose: The present study aimed to evaluate the effect of central line (CL) bundle compliance on line-associated bloodstream infections (CLABSIs) in different departments same hospital, including intensive care unit (ICU) and other departments. Materials Methods:The four components CL were hand hygiene, use maximal sterile barrier precautions, chlorhexidine use, selection an appropriate site for venous access.Compliance CLABSIs measured every department [emergency room (ER), ICU, general...
Abstract Unfortunately, the options for treating multidrug-resistant (MDR) Acinetobacter baumannii ( A . ) infections are extremely limited. Recently, fosfomycin and minocycline were newly introduced as a treatment option MDR infection. Therefore, we investigated efficacy of combination colistin with minocycline, respectively, therapeutic in pneumonia. We examined carbapenem-resistant isolated from clinical specimens at Severance Hospital, Seoul, Korea. The effect fosfomycin, on bacterial...
Here, we examine peripheral blood memory T cell responses against the SARS-CoV-2 BA.4/BA.5 variant spike among vaccinated individuals with or without Omicron breakthrough infections. We provide evidence supporting a lack of original antigenic sin in CD8 + targeting spike. show that BNT162b2-induced cells respond to Among BA.1/BA.2 infections, IFN-γ–producing increased. In subgroup BA.2 BA.2-mutated region increased and correlated directly spike, indicating spike–specific elicited by...
Since the diagnosis of extrapulmonary tuberculosis (EPT) is largely depended on physician's suspicion in respect disease, we believed that it would be worthwhile to scrutinize clinical characteristics EPT. Thus, here present retrospectively evaluated manifestations patients who were diagnosed as EPT cases a tertiary referral care hospital. Medical records 312 patients, having at Yongdong Severance hospital from January 1997 December 1999, reviewed retrospectively. In total 149 (47.8%) males...
Only a few observational studies investigated the association between hypochloremia and mortality in critically ill patients, these included small number of septic patients. Also, no study has evaluated effect an increase chloride (Cl-) concentration on mortality. A total 843 Korean patients were divided into three groups based their baseline Cl- level, Cox analyses performed to evaluate 28-day Moreover, change level (ΔCl) from 24, 48, or 72 hour was determined, also conducted relationship...