A5088473555- Hippo pathway signaling and YAP/TAZ
- CAR-T cell therapy research
- Cancer-related gene regulation
- Chronic Myeloid Leukemia Treatments
- Cancer-related Molecular Pathways
- Wnt/β-catenin signaling in development and cancer
- Spine and Intervertebral Disc Pathology
- Acute Lymphoblastic Leukemia research
- Cancer Immunotherapy and Biomarkers
- Endoplasmic Reticulum Stress and Disease
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Seismic Waves and Analysis
- Fibroblast Growth Factor Research
- Anesthesia and Pain Management
- Kruppel-like factors research
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Seismic Imaging and Inversion Techniques
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Spinal Fractures and Fixation Techniques
- RNA regulation and disease
- Monoclonal and Polyclonal Antibodies Research
- Reproductive System and Pregnancy
Seoul National University Hospital
2021-2024
Boramae Medical Center
2024
Seoul National University
2016-2024
Kangwon National University
2008-2023
Korea Advanced Institute of Science and Technology
2008-2021
Korea University Medical Center
2016-2018
New Hope Fertility Center
2015-2017
Korea University
2017
Creative Research
2010-2013
Initiatives (Denmark)
2010-2013
Loss of Hippo signaling in Drosophila leads to tissue overgrowth as a result increased cell proliferation and decreased death. YAP (a homolog Yorkie target the pathway) was recently implicated control organ size, epithelial development, tumorigenesis mammals. However, role mammalian pathway such regulation has remained unclear. We now show that mice with liver-specific ablation WW45 Salvador adaptor for kinase) manifest liver size expansion hepatic progenitor cells (oval cells) eventually...
VEGF-A drives T cell exhaustion via TOX-dependent transcriptional programming in microsatellite stable colorectal cancers.
Abstract The Hippo pathway regulates the self-renewal and differentiation of various adult stem cells, but its role in cell fate determination during liver development remains unclear. Here we report that controls lineage specification proliferation separately from Notch signalling, using mice primary hepatoblasts with liver-specific knockout Lats1 Lats2 kinase, direct upstream regulators YAP TAZ. During after development, activation YAP/TAZ induced by loss Lats1/2 forces or hepatocytes to...
Purpose: Smartphone use has dramatically increased in recent years. Smartphones may have adverse health effects, particularly on the eyes, because users stare at screen for a much longer time than they do with ordinary mobile phones. The objective of this study was to elucidate relationship between smartphone and ocular symptoms among adolescents.Methods: Information (blurring, redness, visual disturbance, secretion, inflammation, lacrimation dryness) related eye fatigue strain from 715...
Mammalian sterile 20-like kinases 1 and 2 (Mst1 Mst2, respectively) are potent serine/threonine that involved in cell proliferation death. To investigate the physiological functions of Mst1 we generated Mst2 mutant mice. Mst1(-/-) Mst2(-/-) mice were viable fertile developed normally, suggesting possible functional overlaps between two genes. A characterization heterozygous homozygous combinations showed containing a single copy either gene underwent normal organ development; however,...
Respiratory distress syndrome (RDS), which is induced by insufficient production of surfactant, the leading cause mortality in preterm babies. Although several transcription factors are known to be involved surfactant protein expression, molecular mechanisms and signaling pathways upstream these have remained elusive. Here, using mammalian Hippo kinases (Mst1/2, sterile 20-like kinase 1/2) conditional knockout mice, we demonstrate that Mst1/2 critical for orchestration homeostasis prevention...
Although the incidence of severe fever with thrombocytopenia syndrome virus (SFTSV) infection has increased from its discovery a mortality rate 10-20%, no effective vaccines are currently available. Here we describe development SFTSV DNA vaccine, immunogenicity, and protective efficacy. Vaccine candidates induce both neutralizing antibody response multifunctional SFTSV-specific T cell in mice ferrets. When vaccine efficacy is investigated aged-ferrets that recapitulate fatal clinical...
Immune checkpoint inhibitors (ICI) are used for the treatment of various cancers, but clinical trials anti-programmed cell death protein 1 (PD-1) with patients recurrent glioblastoma (GBM) have failed to show benefits. In this study, we examined differentiation status CD8+ tumor-infiltrating lymphocytes (TIL) from primary GBM and their reinvigoration by ICIs understand nature T-cell exhaustion in GBM.We isolated TILs 98 newly diagnosed expression immune receptors transcription factors using...
Endoplasmic reticulum (ER) stress generally occurs in secretory cell types. It has been reported that Leydig cells, which produce testosterone response to human chorionic gonadotropin (hCG), express key steroidogenic enzymes for the regulation of synthesis. In this study, we analyzed whether hCG induces ER via three unfolded protein (UPR) pathways mouse tumor (mLTC-1) cells and testis. Treatment with induced mLTC-1 ATF6, IRE1a/XBP1, eIF2α/GADD34/ATF4 UPR pathways, transient expression 50 kDa...
Human pancreatic ductal adenocarcinoma (PDAC) is a cancer with dismal prognosis. The efficacy of PDAC anticancer therapies often short-lived; however, there little information on how this disease entity so frequently gains resistance to treatment. We adopted the concept stem cells (CSCs) explain mechanism and evaluated candidate drug target these therapy-resistant CSCs. identified subpopulation in CSC features that were enriched for aldehyde dehydrogenase (ALDH), marker expressed certain...
Abstract The mammalian Hippo signaling pathway has been implicated in oncogenesis the context of solid tumors such as hepatocellular carcinoma. Mammalian sterile 20–like kinase 1 (MST1), core component pathway, is highly expressed hematopoietic cells. However, its possible impact on tumorigenesis this setting unknown. In study, we provide evidence that Mst1 loss mouse enhances chemically and genetically induced lymphoma development by inducing chromosomal instability. deficiency increased...
Superovulation induced by exogenous gonadotropin treatment (PMSG/hCG) increases the number of available oocytes in humans and animals. However, Superovulatory PMSG/hCG is known to affect maternal environment, these effects may result from treatment-induced oxidative stress. 2-Cys peroxiredoxins (2-Cys Prxs) act as antioxidant enzymes that protect cells stress various stimuli. Therefore, objective this study was test hypothesis repeated induces Prx expression overoxidation reproductive tracts...
Purpose The purpose of this study was to reveal the clinicopathological characteristics and prognostic implications associated with fibroblast growth factor receptor 1 (FGFR1) amplification in colorectal cancers (CRCs). Materials Methods We measured copy number FGFR1 by droplet digital polymerase chain reaction (ddPCR), analyzed expression immunohistochemistry, 764 surgically resected CRCs (SNUH2007 dataset, 384 CRCs; SNUH Folfox 380 CRCs). Results ≥ 3.3 copies gene were classified as...
Reactive poly(pentafluorophenyl acrylate) (PPFPA)-grafted surfaces offer a versatile platform to immobilize biomolecules. Here, we utilize PPFPA-grafted surface and double-stranded RNA (dsRNA) recognizing J2 antibody construct universal virus detection with enhanced sensitivity. PPFPA on silicon substrates is prepared, hydrophilicity modulated by partial substitution of the pentafluorophenyl units poly(ethylene glycol). Following dsRNA immobilization, prepared can distinguish long dsRNAs...
OBJECTIVE Most studies on the enhanced recovery after surgery (ERAS) protocol in spine have focused patients with degenerative spinal diseases (DSDs), resulting a lack of evidence for comprehensive ERAS applicable to primary tumors (PSTs) and other diseases. The authors had developed gradually adopted components all surgical procedures from 2003 2011, then current was fully implemented 2012. This study aimed evaluate impact applicability across compare outcomes between PST DSD groups....
Abstract The mammalian Hippo signaling pathway has been implicated in the self-renewal and differentiation of stem progenitor cells. MST1 MST2 (MST1/2) are core serine-threonine kinases pathway, one which, MST1, extensively investigated for its role T cell myeloid function. These studies have identified as a promising therapeutic target immunological disease. However, roles MST1/2 hematopoietic (HSC) function vivo not fully understood. Here, we report that mice with conditional deletion...
Abstract IL-15 exhibits pleiotropic effects on NK and CD8+ T cells contributes to host protection or immunopathology during infection. Although both type I IFNs IFN-γ upregulate expression, their upregulation underlying mechanisms have not been compared comprehensively. In addition, little is known about trans-presentation of by epithelial lymphocytes. this study, we analyzed the expression IL-15Rα in human hepatocyte-derived Huh-7 cell line after stimulation with IFN-α, IFN-β, using RT-PCR,...
ABSTRACT We characterize the sources of background noise recorded by an ocean-bottom seismometer array deployed on oldest oceanic lithosphere western Pacific plate. This igneous crust is blanketed up to 1000 m cover sediments, making it a unique place investigate correlations between sediment thickness and levels in marine environment. Although data are limited, we found that thicker sediments attenuated short-period amplified long-period levels, agreement with observations made for seismic...