A5081167839- Sinusitis and nasal conditions
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Olfactory and Sensory Function Studies
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Head and Neck Surgical Oncology
- Obstructive Sleep Apnea Research
- Long-Term Effects of COVID-19
- Immunotherapy and Immune Responses
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- IL-33, ST2, and ILC Pathways
- Biochemical Analysis and Sensing Techniques
- Cytomegalovirus and herpesvirus research
- Advanced Chemical Sensor Technologies
- Renal Transplantation Outcomes and Treatments
- Oral and Maxillofacial Pathology
- Ear Surgery and Otitis Media
- Facial Nerve Paralysis Treatment and Research
- Immune Response and Inflammation
- Respiratory viral infections research
- S100 Proteins and Annexins
Yonsei University
2014-2025
Korea Advanced Institute of Science and Technology
2019-2025
Yonsei University Health System
2024
Severance Hospital
2022-2024
Memory T cells contribute to rapid viral clearance during re-infection, but the longevity and differentiation of SARS-CoV-2-specific memory remain unclear. Here we conduct ex vivo assays evaluate CD4+ CD8+ cell responses in COVID-19 convalescent patients up 317 days post-symptom onset (DPSO), find that are maintained study period regardless severity COVID-19. In particular, observe sustained polyfunctionality proliferation capacity cells. Among detected by activation-induced markers,...
Abstract Invariant natural killer T (iNKT), mucosal-associated invariant (MAIT), and γδ cells are innate that acquire memory phenotype in the thymus share similar biological characteristics. However, how their effector differentiation is developmentally regulated still unclear. Here, we identify analogous subsets of these three cell types transcriptional profiles. Using single-cell RNA sequencing, show iNKT, MAIT mature via shared, branched rather than linear maturation or TCR-mediated...
Subsets of the human CD8+ T cell population express inhibitory NK receptors, such as killer immunoglobulin-like receptors (KIRs) and NKG2A. In present study, we examine phenotypic functional characteristics KIR+CD8+ cells NKG2A+CD8+ cells. KIRs NKG2A tend to be expressed by in a mutually exclusive manner. addition, TCR clonotypes barely overlap with those cells, are more terminally differentiated replicative senescent than Among cytokine IL12Rβ1, IL12Rβ2, IL18Rβ highly whereas IL2Rβ is...
The liver provides a unique niche of lymphocytes enriched with large proportion innate-like T cells. However, the heterogeneity and functional characteristics hepatic T-cell population remain to be fully elucidated.We obtained sinusoidal mononuclear cells from perfusate healthy donors recipients HBV-associated chronic disease (CLD) during transplantation. We performed CITE-seq analysis CD45+ in combination cell receptor (TCR)-seq flow cytometry examine phenotypes functions CD8+ cells.We...
Abstract Background Chronic inflammation triggers tissue remodeling in human nasal epithelial (HNE) cells. S100A9, a protein secreted by inflammatory cells, exhibits potent proinflammatory activity. However, its effect on HNE cell remodeling, such as squamous metaplasia, remains unclear. Therefore, this study aimed to determine the effects and underlying pathways of S100A9 investigate clinical implications chronic rhinosinusitis (CRS). Methods Cultured cells were treated with S100A9. Bulk...
Regulatory T (Treg) cells are important in preventing acute rejection (AR) solid organ transplantation, but the clinical relevance of different kinetics early after liver transplantation (LT) rejectors and non-rejectors is unclear. We analyzed peripheral blood samples 128 LT recipients receiving basiliximab induction plus tacrolimus immunosuppression. Samples were obtained at pretransplant, D7, D30 LT. Frequency phenotype Tregs by flow cytometry. The predictive value Treg frequency D7 was...
Background and Objectives: Pediatric chronic rhinosinusitis (CRS) significantly affects children’s quality of life learning abilities. This study aimed to evaluate the postoperative outcomes in pediatric patients who underwent functional endoscopic sinus surgery (FESS) for CRS.Methods: A retrospective review was conducted on FESS CRS at 11 university hospitals. The inclusion criteria were under 20 years old with bilateral disease operated between January 2005 December 2021. data collected...
Herein, we found that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-unexposed individuals exhibited an increased frequency of CD4+ T cells against SARS-CoV-2 membrane (M) protein, suggesting M-reactive may be primed by previous infection with common cold coronaviruses (CCCoVs). We confirmed CCCoV cross-recognize M in unexposed individuals. Among disease 2019 (COVID-19) convalescents and individuals, significantly lower functional avidity than reactive to other viruses....
Calprotectin is an antimicrobial peptide primarily secreted by neutrophils. Furthermore, calprotectin secretion increases in patients with chronic rhinosinusitis (CRS) polyps (CRSwNP) and positively correlates neutrophil markers. However, CRSwNP known to be associated type 2 inflammation related tissue eosinophilia. Therefore, the authors investigated expression eosinophils eosinophil extracellular traps (EETs) explored associations between clinical findings of CRS.A total 63 participated,...
Respiratory viral infection increases host susceptibility to secondary bacterial infections, yet the precise dynamics within airway epithelia remain elusive. Here, we elucidate pivotal role of CD47 in epithelium during super-infection. We demonstrated that upon influenza virus infection, expression was upregulated and localized on apical surface ciliated cells primary human nasal or bronchial epithelial cells. This induced exposure provided attachment sites for Staphylococcus aureus, thereby...
Abstract This study aimed to investigate the impact of different types nasal inflammation on regulation entry‐associated genes respiratory viruses, including severe acute syndrome coronavirus 2 (SARS CoV‐2), Middle East (MERS‐CoV), human 229E (HCoV‐229E), and influenza virus, in epithelium. Subjects were classified into three groups: control, eosinophilic chronic rhinosinusitis (ECRS), noneosinophilic CRS (NECRS) groups. Angiotensin‐converting enzyme (ACE2) transmembrane protease serine...