A5048353890- Asthma and respiratory diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Systemic Lupus Erythematosus Research
- Neonatal Respiratory Health Research
- Phagocytosis and Immune Regulation
- Inflammatory Bowel Disease
- Pneumonia and Respiratory Infections
- Oral microbiology and periodontitis research
- Ocular Diseases and Behçet’s Syndrome
- Extracellular vesicles in disease
- Sinusitis and nasal conditions
- Galectins and Cancer Biology
- Immune cells in cancer
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
Yonsei University
2021-2024
Korea Institute of Brain Science
2019
Respiratory viral infection increases host susceptibility to secondary bacterial infections, yet the precise dynamics within airway epithelia remain elusive. Here, we elucidate pivotal role of CD47 in epithelium during super-infection. We demonstrated that upon influenza virus infection, expression was upregulated and localized on apical surface ciliated cells primary human nasal or bronchial epithelial cells. This induced exposure provided attachment sites for Staphylococcus aureus, thereby...
No previously suggested biomarkers of nasal mucosal inflammation have been practically applied in clinical fields, and epithelium-derived secreted proteins as not specifically investigated. The goal this study was to identify that dynamically change during the differentiation from basal cells fully differentiated examine whether can be used inflammation, such chronic rhinosinusitis. To achieve goal, we analyzed two secretomes using isobaric tag for relative absolute quantification technique....
Abstract Intestinal Behçet’s disease (BD) and Crohn’s (CD) present similar manifestations, but there are no specific diagnostic tests to differentiate them. We used a proteomic approach discover novel biomarkers intestinal BD. Colon mucosa tissue samples were obtained from patients with BD or CD using colonoscopy-guided biopsy of the affected bowel. Peptides seven extracted labeled tandem mass tag (TMT) reagents. The peptides identified quantified liquid chromatography-tandem spectrometry...
When the lungs are infected with bacteria, alveolar macrophages (AMs) recruited to site and play a crucial role in protecting host by reducing excessive lung inflammation. However, regulatory mechanisms that trigger recruitment of AMs alveoli during an infection still not fully understood. In this study, we identified critical for NADPH oxidase 4 (NOX4) Staphylococcus aureus infection. We found NOX4 knockout (KO) mice showed decreased increased neutrophils injury response S. compared...