A5043055493- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Plant Gene Expression Analysis
- Genetic Neurodegenerative Diseases
- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Cellular transport and secretion
- Acute Myeloid Leukemia Research
- RNA regulation and disease
- Invertebrate Immune Response Mechanisms
- Connective Tissue Growth Factor Research
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Constructed Wetlands for Wastewater Treatment
- Preterm Birth and Chorioamnionitis
- Plant responses to water stress
- Plant Micronutrient Interactions and Effects
- Ferroptosis and cancer prognosis
Seoul National University
2015-2024
Daegu Gyeongbuk Institute of Science and Technology
2018-2020
Pohang University of Science and Technology
2014-2019
Institute for Basic Science
2018-2019
Bioscience (China)
2019
Multiple transcription factors (TFs) play essential roles in plants under abiotic stress, but how these multiple TFs cooperate stress responses remains largely unknown. In this study, we provide evidence that the NAC (for NAM, ATAF1/2, and CUC2) TF ANAC096 cooperates with bZIP-type ABRE binding factor protein (ABF/AREB) to help survive dehydration osmotic conditions. directly interacts ABF2 ABF4, not ABF3, both vitro vivo. synergistically activate RD29A transcription. Our genome-wide gene...
Abstract Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year overall survival rate. Patients with PDAC display limited benefits after undergoing chemotherapy or immunotherapy modalities. Herein, we reveal that upregulates placental growth factor (PlGF), which directly activates cancer-associated fibroblasts (CAFs) to induce fibrosis-associated collagen deposition in PDAC. prognosis have high PIGF/VEGF expression and an increased number of receptor-expressing CAFs, associated enhanced...
Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits dehydrogenase-mediated conversion cytosolic to mitochondrial acetyl-CoA, as a metabolic checkpoint M1 macrophages. Polarization was not prevented by PDK2 or PDK4 deletion but fully combined PDK4; this lack correlated with improved respiration rewiring breaks are characterized increased...
Abstract Airspace or aerenchyma is crucial for plant development and acclimation to stresses such as hypoxia, drought, nutritional deficiency. Although ethylene-mediated signaling cascades are known regulate formation in stems roots under hypoxic conditions, the precise mechanisms remain unclear. Moreover, cellular dynamics underlying airspace shoots poorly understood. We investigated stage-dependent structural of shoot greater duckweed (Spirodela polyrhiza), a fast-growing aquatic herb with...
CCN1 (CYR61) stimulates active angiogenesis in various tumours, although the mechanism is largely unknown. Here, we report that a key regulator of endothelial tip cell activity angiogenesis. Microvessel networks and directional vascular migration patterns were deformed ccn1-knockdown zebrafish embryos. activated VEGFR2 downstream MAPK/PI3K signalling pathways, YAP/TAZ, as well Rho effector mDia1 to enhance itself. interacted with integrin αvβ3 through CCN1. Integrin inhibitor repressed...
Leaf senescence proceeds with age but is modulated by various environmental stresses and hormones. Salt stress one of the most well-known that accelerate leaf senescence. However, molecular mechanisms integrate salt signalling programmes remain elusive. In this study, we characterised role ETHYLENE RESPONSIVE FACTOR34 (ERF34), an Arabidopsis APETALA2 (AP2)/ERF family transcription factor, in ERF34 was differentially expressed under senescence-inducing conditions, negatively regulated induced...
Dendrite aberration is a common feature of neurodegenerative diseases caused by protein toxicity, but the underlying mechanisms remain largely elusive. Here, we show that nuclear polyglutamine (polyQ) toxicity resulted in defective terminal dendrite elongation accompanied loss Golgi outposts (GOPs) and decreased supply plasma membrane (PM) Drosophila class IV dendritic arborization (da) (C4 da) neurons. mRNA sequencing revealed genes downregulated polyQ proteins included many secretory...
Significance It remains unclear how the structural properties of polyglutamine (polyQ) proteins, which underlie several neurodegenerative disorders, including Huntington’s disease and spinocerebellar ataxias (SCAs), translate into toxicity these proteins. Here, we demonstrate that coiled-coil structures in expanded polyQ regions SCA type 3 (SCA3) proteins cause dendrite defects Drosophila neurons, as well behavioral abnormalities. Moreover, interactions SCA3 with Foxo mediated by domains two...
Abstract Inactivation of tumor suppressor Runt-related transcription factor 3 (RUNX3) plays an important role during early tumorigenesis. However, posttranslational modifications (PTM)-based mechanism for the inactivation RUNX3 under hypoxia is still not fully understood. Here, we demonstrate a that G9a, lysine-specific methyltransferase (KMT), modulates through PTM hypoxia. Hypoxia significantly increased G9a protein level and interacted with Runt domain, which led to methylation at K129...
Microglia (MG), the principal neuroimmune sentinels in brain, continuously sense changes their environment and respond to invading pathogens, toxins, cellular debris, thereby affecting neuroinflammation. Microbial pathogens produce small metabolites that influence neuroinflammation, but molecular mechanisms determine whether pathogen-derived affect microglial activation of neuroinflammation remain be elucidated. We hypothesized odorant receptors (ORs), largest subfamily G protein-coupled...
Abstract Mutations in the Microrchidia CW-type zinc finger 2 (MORC2) GHKL ATPase module cause a broad range of neuropathies, such as Charcot-Marie-Tooth disease type 2Z; however, aetiology and therapeutic strategy are not fully understood. Previously, we reported that Morc2a p.S87L mouse model exhibited neuropathy muscular dysfunction through DNA damage accumulation. In present study, analysed gene expression mice designated primary causing factor. We investigated pathological pathway using...
Abstract KRAS-mutant non-small cell lung cancer (NSCLC) is a major subtype that leads to many cancer-related deaths worldwide. Although numerous studies on type NSCLC have been conducted, new oncogenic or tumor suppressive genes need be detected because large proportion of patients does not respond currently used therapeutics. Here, we show the tumor-promoting function cycle-related protein, PIERCE1, in NSCLC. Mechanistically, PIERCE1 depletion inhibits growth and AKT phosphorylation (pAKT)...
Abstract Many of duplicated genes are enriched in signaling pathways. Recently, gene duplication kinases has been shown to provide genetic buffering and functional diversification cellular signaling. Transcription factors (TFs) also often duplicated. However, how TFs affects their regulatory structures functions target not explored at the systems level. Here, we examined roles three major ARR (ARR1, 10 12) Arabidopsis cytokinin using wild-type single, double triple deletion mutants TFs....
Dendrite pathology is frequently observed in various neurodegenerative diseases (NDs). Although previous studies identified several pathogenic mediators of dendrite defects that act through loss function NDs, the underlying mechanisms remain largely unexplored. Here, our search for additional contributors to NDs identifies Relish/NF-κB as a novel gain-of-toxicity–based mediator animal models polyglutamine (polyQ) and amyotrophic lateral sclerosis (ALS). In Drosophila model polyQ diseases,...
Preterm birth (PTB), defined as at less than 37 weeks of gestation, is a major determinant neonatal mortality and morbidity. Early diagnosis PTB risk followed by protective interventions are essential to reduce adverse outcomes. However, due the redundant nature clinical conditions with other diseases, PTB-associated parameters poor predictors PTB. To identify molecular signatures predictive high accuracy, we performed mRNA sequencing analysis patients full-term (FTB) controls in Korean...
Mammalian cells have cytoplasmic and mitochondrial aminoacyl-tRNA synthetases (ARSs) that catalyze aminoacylation of tRNAs during protein synthesis. Despite their housekeeping functions in synthesis, recently, ARSs ARS-interacting multifunctional proteins (AIMPs) been shown to play important roles disease pathogenesis through interactions with disease-related molecules. However, there are lacks data resources analytical tools can be used examine associations ARS/AIMPs. Here, we developed an...
Neuroblastoma is a solid, heterogeneous pediatric tumor. Chemotherapy widely used to treat neuroblastoma. However, dose-dependent responses and chemoresistance mechanisms of neuroblastoma cells anticancer drugs remain challenging. Here, we investigated the effects topotecan on human (SK-N-SH, SH-SY5Y, SK-N-BE) under various nutrient supply conditions. Serum-starved showed reduced toxicity. Their survival rate increased upon treatment with high concentration (1 μM) topotecan. Quantitative...