A5101404637- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Asthma and respiratory diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Respiratory and Cough-Related Research
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Adipose Tissue and Metabolism
- Cancer Genomics and Diagnostics
- Drug-Induced Hepatotoxicity and Protection
- Pediatric Hepatobiliary Diseases and Treatments
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Cancer, Lipids, and Metabolism
- Organ Transplantation Techniques and Outcomes
- Hip and Femur Fractures
- Genomics, phytochemicals, and oxidative stress
- Immune Cell Function and Interaction
- Cannabis and Cannabinoid Research
- Bone fractures and treatments
Korea Research Institute of Bioscience and Biotechnology
2015-2025
Keimyung University
2016-2025
Keimyung University Dongsan Medical Center
2016-2025
Korea University of Science and Technology
2011-2025
Korea University
2025
Yonsei University
2013-2024
Kangwon National University
2011-2024
Chungnam National University
2009-2024
University of California, Los Angeles
2020
Soonchunhyang University
1994-2019
No effective treatment for acute lung injury and fibrosis currently exists. Aim of this study was to investigate the time-dependent effect bone marrow-derived mesenchymal stem cells (BMDMSCs) on bleomycin (BLM)-induced nitric oxide metabolites inflammatory cytokine production. BMDMSCs were transferred 4 days after BLM inhalation. Wet/dry ratio, bronchoalveolar lavage cell profiles, histologic changes deposition collagen analyzed. Nitrite, nitrate cytokines measured weekly through day 28. At...
Sodium butyrate, a short-chain fatty acid naturally present in the human colon, is able to induce cell cycle arrest, differentiation and apoptosis various cancer cells. butyrate most probably related inhibition of deacetylases leading hyperacetylation chromatin components such as histones non-histone proteins alterations gene expression. In this study, we demonstrate for first time that sodium selectively up-regulated DR5 but had no effect on expression other TNF-alpha-related...
(See the article by O'Brien et al, on pages 252–61, and editorial commentary Beck 172–3.)
In June 2015, a local public health laboratory was notified that students had developed gastroenteritis symptoms after attending camp. An outbreak investigation conducted to determine the extent and cause of outbreak.A retrospective cohort study correlations between illness specific exposures at school All attendees were interviewed with standard questionnaire addressed clinical symptoms, food consumption, environmental exposures. Clinical specimens cultured using microbiological methods for...
Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits dehydrogenase-mediated conversion cytosolic to mitochondrial acetyl-CoA, as a metabolic checkpoint M1 macrophages. Polarization was not prevented by PDK2 or PDK4 deletion but fully combined PDK4; this lack correlated with improved respiration rewiring breaks are characterized increased...
Glucose-6-phosphate dehydrogenase (G6PD), a rate-limiting enzyme of the pentose phosphate pathway, plays important roles in redox regulation and de novo lipogenesis. It was recently demonstrated that aberrant upregulation G6PD obese adipose tissue mediates insulin resistance as result imbalanced energy metabolism oxidative stress. remains elusive, however, whether inhibition vivo may relieve obesity-induced resistance. In this study we showed hematopoietic defect alleviates obesity,...
Aspirin-intolerant asthma (AIA) is a rare condition that characterized by the development of bronchoconstriction in asthmatic patients after ingestion non-steroidal anti-inflammatory drugs including aspirin. However, underlying mechanisms AIA occurrence are still not fully understood. To identify genetic variations associated with aspirin intolerance asthmatics, first stage genome-wide association study 109,365 single nucleotide polymorphisms (SNPs) was undertaken Korean (n = 80) cohort and...
This study was undertaken to generate and characterize human induced pluripotent stem cells (PSCs) from patients with osteoarthritis (OA) examine whether these can be developed into disease-relevant cell types for use in disease modeling drug discovery.Human synovial isolated two 71-year-old women advanced OA were characterized reprogrammed PSCs by ectopic expression of 4 transcription factors (Oct-4, SOX2, Klf4, c-Myc). The pluripotency status each PSC line validated comparison embryonic...
Abstract Introduction We report our experience with laparoscopic major liver resection in Korea based on a multicenter retrospective study. Materials and methods Data from 1,009 resections conducted 2001 to 2011 were retrospectively collected. Twelve tertiary medical centers specialized hepatic surgeons participated this Results Among resections, performed 265 patients as treatment for hepatocellular carcinoma, metastatic tumor, intrahepatic duct stone, other conditions. The most frequently...
Although liquid biopsy of blood is useful for cancer diagnosis and prediction prognosis, diagnostic prognostic value ctDNA in bile fluid BTCs are not clear yet. To determine whether circulating tumor DNA (ctDNA) can replace tissue when assessing somatic mutations biliary tract cancers (BTCs). Bile samples were obtained from 42 patients with BTC. Matched formalin-fixed paraffin-embedded (FFPE) 20 these matched plasma 16 them. Droplet digital PCR (ddPCR) was used detection KRAS mutation....
Our research objective was to increase isoflavone content in the germinated soybean seeds of four different varieties (Pungsannamulkong, Cheongjakong, Aga4, and Aga3) by optimizing light treatments (dark, greenhouse, fluorescent, incandescent, ultraviolet lamps). The results demonstrated that highest produced from Aga3 variety, which developed an interspecific cross between Eunhakong (Glycine max) KLG10084 (G. soja) at Plant Genetic Laboratory, Kyunpook National University. is known have one...
Hepatic gluconeogenesis is tightly balanced by opposing stimulatory (glucagon) and inhibitory (insulin) signaling pathways. Hepatocyte growth factor (HGF) a pleiotropic that mediates diverse biological processes. In this study, we investigated the effect of HGF its family member, macrophage-stimulating (MSP), on hepatic in primary hepatocytes. MSP significantly repressed expression key gluconeogenic enzyme genes, phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (Glc-6-Pase)...
Gene expression is suppressed by DNA methylation. The goal of this study was to identify genes whose CpG site methylation and mRNA are associated with recurrence after surgical resection for hepatocellular carcinoma (HCC). Sixty-two HCCs were examined both whole genome transcriptome analysis. Cox model used select recurrence. A validation performed in an independent cohort 66 HCC patients. Among fifty-nine common genes, increased decreased 12 (Group A), whereas 25 B). remaining 22 defined as...
One of the clinical manifestations refractory asthma (RA) in a certain group patients is persistent airway obstruction (PAO), despite treatment with high doses inhaled and/or systemic corticosteroids. Airway neutrophilic inflammation frequently observed RA; however, relationship between and PAO has not been evaluated this patients. The aim study was to compare parameters patterns inflammatory cells or without due RA, identify factors associated PAO.Seventy-seven RA were recruited from cohort...
Hypertension is one of the most common human diseases worldwide, and extensive research efforts are focused upon identification utilizing novel therapeutic drug targets. Nitric oxide (NO) produced by endothelial NO synthase (eNOS) an important regulator blood pressure (BP). β-Lapachone (βL), a well-known substrate NAD(P)H:quinone oxidoreductase (NQO1), increases cellular NAD(+)/NADH ratio via activation NQO1. In this study, we evaluated whether βL-induced NQO1 modulates BP in animal model...
Piperlongumine (PL), a biologically active compound from the Piper species, has been shown to exert various pharmacological effects in number of conditions, including tumours, diabetes, pain, psychiatric disorders and neurodegenerative disease. In this study, we evaluated therapeutic PL on hippocampal function cognition decline aged mice. (50 mg/kg/day) was intragastrically administrated 23‑month‑old female C57BL/6J mice for 8 weeks. Novel object recognition nest building behaviour tests...
Serum α-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3), and des-γ-carboxy-pro-thrombin (DCP) are useful biomarkers of hepatocellular carcinoma (HCC). However, associations among molecular characteristics serum unclear. We analyzed RNA expression DNA variant data from The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) to examine their with biomarker levels clinical data.From 371 TCGA-LIHC patients, we selected 91 seen at 3 institutions in Korea the USA...
Isoflavones decrease blood pressure, improve lipid profiles, and restore vascular function. We hypothesized that isoflavone attenuates contraction by inhibiting RhoA/Rho-kinase signaling pathway. Rat aortic rings were denuded of endothelium, mounted in organ baths, contracted with 11,9 epoxymethano-prostaglandin F<sub>2α</sub> (U46619), a thromboxane A2 analog, or KCl 30 min after the pretreatment genistein (4′,5,7-trihydroxyisoflavone), daidzein (4′,7-dihydroxyisoflavone), vehicle....