A5035820997- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Animal Virus Infections Studies
- Viral Infections and Outbreaks Research
- Viral Infections and Immunology Research
- Fire effects on ecosystems
- Immune Cell Function and Interaction
- Biosensors and Analytical Detection
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- vaccines and immunoinformatics approaches
- Infectious Encephalopathies and Encephalitis
- Infection Control and Ventilation
- COVID-19 and Mental Health
- Surface Roughness and Optical Measurements
- Congenital Diaphragmatic Hernia Studies
- Receptor Mechanisms and Signaling
- Herbal Medicine Research Studies
- Advancements in Photolithography Techniques
- Virus-based gene therapy research
Afrivac
2021
CHA Vaccine Institute (South Korea)
2021
Chungbuk National University
2011-2020
Medical Research Institute
2013-2015
Cheongju University
2013
Background. Although Middle East Respiratory Syndrome coronavirus (MERS-CoV) is characterized by a risk of nosocomial transmission, the detailed mode transmission and period virus shedding from infected patients are poorly understood. The aims this study were to investigate potential role environmental contamination MERS-CoV in healthcare settings define viable MERS patients.
Abstract Background In addition to seasonal influenza viruses recently circulating in humans, avian (AIVs) of H5N1, H5N6 and H7N9 subtypes have also emerged demonstrated human infection abilities with high mortality rates. Although viral infections are usually diagnosed using isolation serological/molecular analyses, the cost, accessibility, availability these methods may limit their utility various settings. The objective this study was develop optimized a multiplex detection system for...
The endemicity of highly pathogenic avian influenza (HPAI) A(H5N1) viruses in Asia has led to the generation reassortant H5 strains with novel gene constellations. A newly emerged HPAI A(H5N8) virus caused poultry outbreaks Republic Korea 2014. Because emerging high-pathogenicity continue pose public health risks, it is imperative that their pathobiological properties be examined. Here, we characterized A/mallard duck/Korea/W452/2014 (MDk/W452(H5N8)), a representative virus, and evaluated...
Although the incidence of severe fever with thrombocytopenia syndrome virus (SFTSV) infection has increased from its discovery a mortality rate 10-20%, no effective vaccines are currently available. Here we describe development SFTSV DNA vaccine, immunogenicity, and protective efficacy. Vaccine candidates induce both neutralizing antibody response multifunctional SFTSV-specific T cell in mice ferrets. When vaccine efficacy is investigated aged-ferrets that recapitulate fatal clinical...
As the pandemic (H1N1) 2009 influenza virus continues to infect human populations globally, reports on epidemiologically linked animal infections are also rise. Since December 2009, 2009-like viruses have been isolated in pigs from different swine farms of South Korea. Genetic and phylogenetic analyses viral segments demonstrated several events human-to-swine transmission with no apparent signs reassortment. These were supported by serological surveillance pig sera collected April December,...
Neuraminidase inhibitors (NAIs) have been widely used to control influenza virus infection, but their increased use could promote the global emergence of resistant variants. Although various mutations associated with NAI resistance identified, amino acid substitutions that confer multidrug undiminished viral fitness remain poorly understood. We therefore screened a known mutation(s) currently approved NAIs oseltamivir, zanamivir, and peramivir by assessing recombinant viruses mutant...
MicroRNAs (miRNAs) are known to regulate various biological processes, including expression of cellular gene and virus-induced inflammation. Recently, studies have indicated that some miRNAs could influenza virus replication. Due differential sensitivities A strains different species (avian mammalian), variations in host responses may be observed. Therefore, we investigated compared the differences global miRNA mouse lungs infected with wild type low pathogenicity A/Aquatic...
A novel genotype of H5N6 influenza viruses was isolated from migratory birds in South Korea during November 2016. Domestic outbreaks this virus were associated with die-offs wild near reported poultry cases Chungbuk province, central Korea. Genetic analysis and animal studies demonstrated that the Korean are highly pathogenic avian (HPAI) these reassortants at least three different subtypes (H5N6, H4N2 H1N1).
Several subtypes of avian influenza viruses (AIVs) are emerging as novel human pathogens, and the frequency related infections has increased in recent years. Although neuraminidase (NA) inhibitors (NAIs) only class antiviral drugs available for therapeutic intervention AIV-infected patients, studies on NAI resistance among AIVs have been limited, markers poorly understood. Previously, we identified unique substitutions N3, N7, N9 NA subtypes. Here, report profiles that confer N4, N5, N6, N8...
Efficient worldwide swine surveillance for influenza A viruses is urgently needed; the emergence of a novel reassortant pandemic H1N1 (pH1N1) virus in 2009 demonstrated that can be direct source and potential prevalent populations must monitored. We used ferret model to assess pathogenicity transmissibility predominant Korean triple-reassortant (TRSw) H1N2 H3N2 genetically related North American strains. Although most TRSw were moderately pathogenic, one [A/Swine/Korea/1204/2009; Sw/1204...
Highly pathogenic avian influenza (HPAI) A(H5N6) and A(H5N8) virus infections resulted in the culling of more than 37 million poultry Republic Korea during 2016/17 winter season. Here we characterize two representative viruses, A/Environment/Korea/W541/2016 [Em/W541(H5N6)] A/Common Teal/Korea/W555/2017 [CT/W555(H5N8)], evaluate their zoonotic potential various animal models. Both Em/W541(H5N6) CT /W555(H5N8) are novel reassortants derived from gene pools wild bird viruses present migratory...
Abstract African swine fever virus (ASFV) is the causative agent of highly lethal disease that affects domestic pigs and wild boars. In spite rapid spread worldwide, there no licensed vaccine available. The lack a suitable cell line for ASFV propagation hinders development safe effective vaccine. For propagation, primary macrophages monocytes have been widely studied. However, obtaining these cells can be time-consuming expensive, making them unsuitable mass production. goal this study was...
The current pandemic (H1N1) 2009 virus remains transmissible among humans worldwide with cases of reverse zoonosis, providing opportunities to produce more pathogenic variants which could pose greater human health concerns. To investigate whether recent seasonal or swine H1N1 vaccines induce cross-reactive immune responses against infection the virus, mice, ferrets mini-pigs were administered various regimens (once twice) and antigen content (1.77, 3.5 7.5 µg HA) a-Brsibane/59/07, a-CAN01/04...
We investigated influenza A(H5N6) viruses from migratory birds in Chungnam and Gyeonggi Provinces, South Korea following a reported die-off of poultry nearby provinces November 2017. Genetic analysis virulence studies chickens ducks identified our isolate December 2017 as novel highly pathogenic avian virus. It resulted reassortment between the virulent H5N8 strain with N6 gene low-pathogenic H3N6 virus Netherlands.
Abstract Background Influenza vaccines are prepared annually based on global epidemiological surveillance data. However, since there is no method by which to predict the influenza strain that will cause next pandemic, demand develop new vaccination strategies with broad cross-reactivity against viruses clearly important. The ectodomain of M2 protein (M2e) an attractive target for developing a vaccine cross-reactivity. For these reasons, we investigated efficacy inactivated H9N2 virus...
In order to produce a dually effective vaccine against H9 and H5 avian influenza viruses that aligns with the DIVA (differentiating infected from vaccinated animals) strategy, we generated chimeric H9/H5N2 recombinant expressed whole HA1 region of A/CK/Korea/04163/04 (H9N2) HA2 recent highly pathogenic (HPAI) A/MD/Korea/W452/14 (H5N8) viruses. The virus showed in vitro vivo growth properties virulence were similar those low-pathogenic (LPAI) virus. An inactivated based on this induced serum...
Abstract To investigate the molecular changes that allow influenza B viruses to adapt new mammalian hosts, B/Florida/04/2006 was serially passaged in BALB/c mice until highly virulent. The viral factors underlying this transition were then investigated and ferrets. Five viruses, including wild-type virus (P0), three intermediate (P5, P9 P12) a lethal mouse-adapted (P17 (MA)), harbored one five amino acid substitutions hemagglutinin, M, NP PA segments suggesting these mutations enhance...