A5081281913- Healthcare Policy and Management
- Health Systems, Economic Evaluations, Quality of Life
- Primary Care and Health Outcomes
- Chromosomal and Genetic Variations
- Health Policy Implementation Science
- Microscopic Colitis
- Liver Disease and Transplantation
- Pharmaceutical Practices and Patient Outcomes
- Healthcare cost, quality, practices
- Hemoglobinopathies and Related Disorders
- Celiac Disease Research and Management
- Medical Imaging and Pathology Studies
- Cutaneous Melanoma Detection and Management
- Emergency and Acute Care Studies
- Genetics and Neurodevelopmental Disorders
- Pharmacology and Obesity Treatment
- Viral Infections and Vectors
- Radiomics and Machine Learning in Medical Imaging
- CRISPR and Genetic Engineering
- Nonmelanoma Skin Cancer Studies
- Venous Thromboembolism Diagnosis and Management
- Medication Adherence and Compliance
- Immune Cell Function and Interaction
- Sirtuins and Resveratrol in Medicine
- Biochemical Acid Research Studies
STCube (United States)
2023
University of Southern California
2018-2022
Fred Hutch Cancer Center
2018-2020
Johns Hopkins University
2017-2020
Johns Hopkins Medicine
2017-2020
Florida Center for Gastroenterology
2019
Cancer Research Center
2018
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2018
VA Central Western Massachusetts Healthcare System
2018
Ottawa Hospital Research Institute
2016
Outlier physician practices in health care can represent a significant burden to patients and the system.
Dabie bandavirus (severe fever with thrombocytopenia syndrome virus [SFTSV]) induces an immunopathogenic disease a high fatality rate; however, the mechanisms underlying its clinical manifestations are largely unknown. In this study, we applied targeted proteomics and single-cell transcriptomics to examine differential immune landscape in SFTS patient blood. Serum immunoprofiling identified low-risk high-risk clusters of patients based on inflammatory cytokine levels, which corresponded...
Uninsured and insured but out-of-network emergency department (ED) patients are often billed hospital chargemaster prices, which exceed amounts typically paid by insurers.To examine the variation in excess charges for services provided medicine internal physicians.Retrospective analysis was conducted of professional fee payment claims made Centers Medicare & Medicaid Services all to Part B fee-for-service beneficiaries calendar year 2013. Data from January 1 July 31, 2016.Markup ratios ED...
Mohs micrographic surgery (MMS) is a skin cancer treatment that uses staged excisions based on margin status. Wide surgeon-level variation exists in the mean number of resections used to treat tumor, resulting cost disparity and question appropriateness.To evaluate effectiveness behavioral intervention aimed at reducing extreme overuse MMS, as defined by specialty society, confidentially sharing stages-per-case performance data with individual surgeons benchmarked their peers nationally.This...
Significance Enhancers are crucial regulatory elements that dictate cellular processes by spatiotemporally controlling promoter activity. Recent studies have shown active enhancers themselves generate noncoding enhancer RNAs (eRNAs) play a critical role in fine tuning gene expression. Using genomic approaches, we demonstrate oncogenic KSHV modulates host activity PELs to control its lifecycle. During latency, expression levels of several key transcription factors and oncogenes elevated...
Genetic ablation as well pharmacological inhibition of sirtuin 2 (SIRT2), an NAD+-dependent protein deacylase, have therapeutic effects in various cancers and neurodegenerative diseases. Previously, we described the discovery a dual SIRT1/SIRT2 inhibitor called cambinol (IC50 56 59 µM, respectively), which showed cytotoxic activity against cancer cells vitro marked anti-proliferative effect Burkitt lymphoma mouse xenograft model. A number recent studies shown protective SIRT1 SIRT3 metabolic...
Cirrhosis is a rapidly increasing cause of global mortality. To improve cirrhosis care, the Veterans Health Administration (VHA) developed Hepatic Innovation Team (HIT) Collaborative to support VA Medical Centers (VAMCs) deliver evidence-based care. This randomized HIT program evaluation aims develop and assess novel approach for choosing applying implementation strategies quality care.Evaluation are (1) empirically determine which combinations associated with successful practices (EBPs)...
After implementing a successful hepatitis C elimination program, the Veterans Health Administration’s (VHA) Hepatic Innovation Team (HIT) Collaborative pivoted to focus on improving cirrhosis care. This national program developed teams of providers across country and engaged them in using systems redesign methods population health approaches improve The HIT an Advanced Liver Disease (ALD) Dashboard identify with who were due for surveillance hepatocellular carcinoma (HCC) other liver care,...
Abstract Background Practical and feasible methods for matching implementation strategies to diagnosed barriers of evidence-based interventions in real-world contexts are lacking. This evaluation compared actual applied with those recommended by an expert opinion-based tool improve guideline-concordant cirrhosis care a Veterans Health Administration national learning collaborative effort. Methods convergent parallel mixed-methods study aimed (1) identify pre-implementation Consolidated...
Physician credentialing processes aim to improve patient safety and quality, but little research has examined their direct relationship with surgical outcomes. Using national Medicare claims for 2009 2013, the authors studied association between board certification completion of Maintenance Certification (MOC) requirements surgeon rates complications 8 elective procedures. Exemplar surgeons were defined as those in lowest decile complication rates, outlier highest decile. The analysis...
Improved anticoagulation control with warfarin reduces adverse events and represents a target for quality improvement. No previous study has described an effort to improve across health system.To describe the results of in New England region Veterans Health Administration (VA).Our intervention encompassed 8 VA sites managing more than 5000 patients (Veterans Integrated Service Network 1 [VISN 1]). We provided system measure processes care, along targeted audit feedback. focused on care...
Background and aims The Veterans Health Administration (VA) cares for over 80,000 with cirrhosis annually. Given the importance of understanding patient reported outcomes in this complex population, we aimed to assess associations between attitudes towards care, disease knowledge, health related quality life (HRQoL) a national sample. Methods In cross-sectional study, mailed paper surveys random sample cirrhosis, oversampling those decompensated disease. Surveys included RAND 12-Item Survey...
We compared the initial medical and surgical management of Crohn's disease (CD) ulcerative colitis (UC) between United States China, with aims to better characterize global variation in treatment patterns inflammatory bowel (IBD).Participants from China completed a questionnaire on demographic clinical characteristics, medications (biologics, immunomodulators, aminosalicylates, steroids), IBD-related history. Patients diagnosed 2006 later were eligible. Analysis was restricted within 1 year...
Results of a study to characterize the experiences warfarin-treated patients, including their in taking medication, communicating with clinical pharmacists, and International Normalized Ratio (INR) monitoring, are reported.A qualitative analysis data obtained during interviews 40 patients at Veterans Affairs medical center warfarin clinic was conducted. In semistructured interviews, were asked describe process whereby INR values monitored by pharmacists understanding self-management...
More than 145,000 Veterans were known to be HCV viremic and approximately 66% of the 1945–1965 birth cohort had been screened for when all-oral direct acting antivirals (DAAs) placed on VA formulary in January 2015. Although addressed screening treatment more 15 years, availability highly effective treatments heightened focus HCV. Beginning FY15, Congress appropriated additional funds DAAs. negotiated favorable pricing DAAs wrote guidelines that allowed patients with without cirrhosis as...