A5083351325- Tuberculosis Research and Epidemiology
- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Bacteriophages and microbial interactions
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Frailty in Older Adults
- Spine and Intervertebral Disc Pathology
- Biochemical and Molecular Research
- Antibiotics Pharmacokinetics and Efficacy
- Spinal Fractures and Fixation Techniques
- Sports injuries and prevention
- Shoulder Injury and Treatment
- Venous Thromboembolism Diagnosis and Management
- Endoplasmic Reticulum Stress and Disease
- Metastasis and carcinoma case studies
- Cardiac tumors and thrombi
- Viral-associated cancers and disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Cerebral Palsy and Movement Disorders
- Musculoskeletal pain and rehabilitation
- Muscle activation and electromyography studies
- Innovation in Digital Healthcare Systems
University of Southern California
2017-2024
Hanyang University
2024
Southern California University for Professional Studies
2024
Sogang University
2012-2023
Samsung (South Korea)
2016-2023
Sungkyunkwan University
2016-2023
Kyung Hee University
1999-2021
Korea Astronomy and Space Science Institute
2013-2021
Hallym University
2015-2019
Moffitt Cancer Center
2016-2019
The stringent response enzyme is a promising new target for Mycobacterium tuberculosis persisters.
Background Systemic cancer spread is preceded by the establishment of a permissive microenvironment in target tissue metastasis -the premetastatic niche.As crucial players pre-metastatic niche, myeloid derived suppressor cells (MDSC) release S100A8/A9, an exosomal protein that contributes to metastasis, angiogenesis, and immune suppression.We report application antibody-based single-photon emission computed tomography (SPECT) for detection S100A8/A9 vivo as imaging marker priming.Methods A...
Abstract Stochastic formation of Mycobacterium tuberculosis (Mtb) persisters achieves a high level antibiotic-tolerance and serves as source multidrug-resistant (MDR) mutations. As conventional treatment is not effective against infections by MDR-Mtb, novel therapeutics are needed. Several approaches were proposed to kill altering their metabolism, obviating the need target active processes. Here, we adapted biofilm culture model Mtb persister-like bacilli (PLB) demonstrated that PLB...
Nontuberculous mycobacterial pulmonary diseases (NTM-PDs) are emerging as global health threats with issues of antibiotic resistance. Accumulating evidence suggests that the gut–lung axis may provide novel candidates for host-directed therapeutics against various infectious diseases. However, little is known about in context host protective immunity to identify new NTM-PDs. This study was performed gut microbes and metabolites capable conferring Using metabolomics analysis sera from NTM-PD...
Thioredoxin-interacting protein (TXNIP) has emerged as a key player in cancer and diabetes since it targets thioredoxin (TRX)-mediated redox regulation glucose transporter (GLUT)-mediated metabolism. TXNIP consists of two arrestin (ARR, N-ARR C-ARR) domains at its amino-terminus PPxY (PY) motifs di-leucine (LL) motif for endocytosis carboxyl-terminus. Here, we report that shuffles between TRX GLUTs to regulate homeostasis intracellular oxidative stress While functions gatekeeper by default,...
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the leading cause of death worldwide infectious disease. Treatment Mtb infection requires a six-month course multiple antibiotics, an extremely challenging regimen necessitated Mtb's ability to form drug-tolerant persister cells. formation dependent on trehalose catalytic shift, stress-responsive metabolic remodeling mechanism in which disaccharide liberated from cell surface glycolipids and repurposed as internal carbon...
Abstract Purpose: A subset of patients with adenocarcinoma the lung who had never smoked cigarettes showed excellent tumor responses to gefitinib therapy. To evaluate efficacy as a first-line therapy in this subgroup patients, we conducted phase II study. Experimental Design: Eligible no smoking history, stage IIIB or IV adenocarcinoma, Eastern Cooperative Oncology Group performance status 0 2, and adequate organ functions. Treatment consisted daily oral administration ofF 250 mg for 28 days...
Resveratrol is a polyphenolic compound in red wine that has anti-oxidant and cardioprotective effects animal models. Reactive oxygen species (ROS) monocyte chemotactic protein-1 (MCP-1) play key roles foam cell formation atherosclerosis. We studied LPS-mediated the effect of resveratrol. pretreatment strongly suppressed LPS-induced formation. To determine if resveratrol affected expression genes control ROS generation macrophages, NADPH oxidase 1 (Nox1) was measured. treatment macrophages...
Abstract Background Sensing and responding to environmental changes is a central aspect of cell division regulation. Mycobacterium tuberculosis contains eleven Ser/Thr kinases, two which, PknA PknB, are key signaling molecules that regulate division/morphology. One substrate these kinases Wag31, we previously showed partial depletion Wag31 caused morphological indicative wall defects, the phosphorylation state affected growth in mycobacteria. In present study, further characterized role...
ABSTRACT While glutamine is a nonessential amino acid that can be synthesized from glucose, some cancer cells primarily depend on for their growth, proliferation, and survival. Numerous types of also asparagine cell proliferation. The underlying mechanisms the requirement in different contexts remain unclear. In this study, we show oncogenic virus Kaposi’s sarcoma-associated herpesvirus (KSHV) accelerates metabolism glucose-independent proliferation by upregulating expression numerous...
Understanding the mechanisms underlying M. tuberculosis adaptive strategies to achieve drug tolerance is crucial for identification of new targets and development drugs. Here, we show that acetate medium triggers a drug-tolerant state in when challenged with antituberculosis (anti-TB)
Significance While understanding metabolic change of tumor cells is crucial to improve cancer therapy, current 2D cell culture condition may not fully recapitulate in vivo environment tumors. Our metabolomics analysis demonstrates that proline metabolism critical for the KSHV-transformed growth 3D culture, culture. Specifically, KSHV K1 oncoprotein activates PYCR biosynthesis enzyme, increasing intracellular concentration vitro spheroid and tumorigenesis. This study describes an oncogenic...
A circularly polarized (CP) patch antenna loaded with a metasurface, which is realized lattice of 4 × square solar cells, presented. The composed slotted circular sandwiched between the metasurface and ground plane. This arrangement not only allows for total exposure cells to sunlight (100% insolation) but also improves performance greatly. final design, an overall size 40 mm 3.5 (0.87λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sub>...
Abstract Metabolic networks in biological systems are interconnected, such that malfunctioning parts can be corrected by other within the network, a process termed adaptive metabolism. Unlike Bacillus Calmette-Guérin (BCG), Mycobacterium tuberculosis (Mtb) better manages its intracellular lifestyle executing Here, we used metabolomics and identified glutamate synthase (GltB/D) converts glutamine to (Q → E) as metabolic effort neutralize cytoplasmic pH is acidified while consuming host...
Significance Nonreplicating (NR) Mycobacterium tuberculosis (Mtb) was thought to be drug tolerant due its low metabolic activity. However, tolerance often gradually increases by exposure antibiotics, inferring the role of an adaptive strategy. This study established that NR Mtb is associated with phosphoenolpyruvate (PEP) anabolic down-regulation. PEP a substrate multiple pathways needed for replication; in Mtb, their functions were abolished depletion. Intriguingly, supplementation partly...
Outbreaks of multidrug-resistant bacterial infections have become more frequent worldwide owing to the emergence several different classes β-lactamases. In this study, molecular, biochemical and structural characteristics an Acinetobacter-derived cephalosporinase (ADC)-type class C β-lactamase, ADC-68, isolated from carbapenem-resistant A. baumannii D015 were investigated. The blaADC-68 gene which encodes ADC-68 was confirmed exist on chromosome via Southern blot analysis draft genome...
Abstract Human hepatocyte culture system represents by far the most physiologically relevant model for our understanding of liver biology and diseases; however, its versatility has been limited due to rapid progressive loss genuine characteristics, indicating inadequacy in vitro milieu fate maintenance. This study, therefore, is designed define environmental requirements necessary sustain homeostasis terminally differentiated hepatocytes. Our study reveals that supplementation dimethyl...
Hamstring shortness is the most common musculoskeletal condition in sports athletes, which often contributes to hamstring strain injury. To effectively mitigate shortness, contemporary HR, SCS, and IASTM soft tissue techniques have been used. The best practical evidence about therapeutic effects biomechanical mechanisms underpinning these manual remain unknown.The purpose of this study was compare on improving quadriceps muscle strength, related ratio, knee joint passive stiffness, pain...
Hypothesis: Anorexia and cancer cachexia produce significant loss of adipose tissue muscle mass eventually reduce survival in patients. Study design: This phase II study was conducted to assess the efficacy safety an herbal decoction with Astragali Radix patients anorexia advanced cancer. Methods: All histologic evidence incurable malignancy had a weight at least 5% during preceding 6 months patient-estimated severe anorexia.The administered 30 minutes after meals, three times day for 3...