A5072650041- Flowering Plant Growth and Cultivation
- Plant Physiology and Cultivation Studies
- Horticultural and Viticultural Research
- Fermentation and Sensory Analysis
- Ecology and Conservation Studies
- Powdery Mildew Fungal Diseases
- interferon and immune responses
- Plant Pathogens and Fungal Diseases
- Plant and animal studies
- Agriculture, Soil, Plant Science
- Cytomegalovirus and herpesvirus research
- Plant tissue culture and regeneration
- Food Quality and Safety Studies
- Garlic and Onion Studies
- Botanical Research and Applications
- Viral-associated cancers and disorders
- Ectopic Pregnancy Diagnosis and Management
- Banana Cultivation and Research
- Postharvest Quality and Shelf Life Management
- Plant Virus Research Studies
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- Inflammasome and immune disorders
- Plant biochemistry and biosynthesis
- Wood and Agarwood Research
Cedars-Sinai Medical Center
2024-2025
University of Southern California
2013-2024
Cleveland Clinic Lerner College of Medicine
2021-2024
Rural Development Administration
2010-2024
Korea International Cooperation Agency
2021
Southern California University for Professional Studies
2014
Health Insurance Review and Assessment Service
2012
National Horticultural Research Institute
2008
Seoul National University Bundang Hospital
2005
Seoul National University
2005
Cases of laboratory-confirmed SARS-CoV-2 reinfection have been reported in a number countries. Further, the level natural immunity induced by infection is not fully clear, nor it clear if primary protective against reinfection. To investigate potential association between serum antibody titres and SARS-CoV-2, ferrets with different levels NAb after were subjected to heterologous strain. All reinfected showed active virus replication upper respiratory gastro-intestinal tracts. However, high...
While the seroprevalence of SARS-CoV-2 in healthy people does not differ significantly among age groups, those aged 65 years or older exhibit strikingly higher COVID-19 mortality compared to younger individuals. To further understand differing manifestations patients different ages, three groups ferrets are infected with SARS-CoV-2. Although is isolated from all regardless age, (≥3 old) show viral loads, longer nasal virus shedding, and more severe lung inflammatory cell infiltration,...
Abstract RIPK3–ZBP1–MLKL-mediated necroptosis is a proinflammatory cell death process that crucial for antiviral host defence. RIPK3 self-oligomerization and autophosphorylation are prerequisites executing necroptosis, yet the underlying mechanism of virus-induced activation remains elusive. Interferon-inducible 2′-5′ oligoadenylate synthetase-like (OASL) protein devoid enzymatic function but displays potent activity. Here we describe role OASL as promoter scaffolds RIPK3–ZBP1 non-canonical...
Thioredoxin-interacting protein (TXNIP) has emerged as a key player in cancer and diabetes since it targets thioredoxin (TRX)-mediated redox regulation glucose transporter (GLUT)-mediated metabolism. TXNIP consists of two arrestin (ARR, N-ARR C-ARR) domains at its amino-terminus PPxY (PY) motifs di-leucine (LL) motif for endocytosis carboxyl-terminus. Here, we report that shuffles between TRX GLUTs to regulate homeostasis intracellular oxidative stress While functions gatekeeper by default,...
One of the hallmarks latent phase Kaposi's sarcoma-associated herpesvirus (KSHV) infection is global repression lytic viral gene expression. Following de novo KSHV infection, establishment latency involves chromatinization incoming genomes and recruitment host Polycomb repressive complexes (PRC1 PRC2) to promoters genes, which accompanied by inhibition genes. However, mechanism how PRCs are recruited episome still unknown. Utilizing a genetic screen genes in context genome, we identified...
Abstract To gain insight into regulatory mechanisms of tissue‐specific Corazonin ( Crz ) gene expression and its functions in Drosophila , we cloned the genes from four species D. melanogaster, simulans, erecta virilis performed comparative analyses sequences patterns using situ hybridization immunohistochemistry. Although showed a great deal diversity, CNS were highly conserved examined here. In melanogaster larva, was found pairs neurons per cerebral lobe eight bilateral ventral nerve...
Significance While understanding metabolic change of tumor cells is crucial to improve cancer therapy, current 2D cell culture condition may not fully recapitulate in vivo environment tumors. Our metabolomics analysis demonstrates that proline metabolism critical for the KSHV-transformed growth 3D culture, culture. Specifically, KSHV K1 oncoprotein activates PYCR biosynthesis enzyme, increasing intracellular concentration vitro spheroid and tumorigenesis. This study describes an oncogenic...
Article16 September 2020Open Access Source DataTransparent process Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2 Kiramage Chathuranga orcid.org/0000-0002-0279-2895 College Veterinary Medicine, Chungnam National University, Daejeon, Korea Search for more papers this author Tae-Hwan Kim Infectious Disease Research Center, Institute Bioscience and Biotechnology, Hyuncheol Lee California Quantitative Biosciences, University California, Berkeley, CA, USA Jun-Seol Park...
ABSTRACT Kaposi's sarcoma‐associated herpesvirus (KSHV) employs diverse mechanisms to subvert host immune responses, contributing its infection and pathogenicity. As an evasion strategy, KSHV encodes the Membrane‐Associated RING‐CH (MARCH)‐family E3 ligases, K3, K5, which target remove several regulators from cell surface. In this study, we investigate impact of K3 K5 on lymphotoxin receptor (LTβR) ligands, LTβ LIGHT, are type II transmembrane proteins function as pivotal mediators during...
Stroke is a major health problem in Korea. It the second leading cause of death, and many stroke survivors are permanently disabled. Despite high economic social burden stroke, little known about utilization care services for sufficiently long follow-up periods. This study assessed nationwide patterns hospitalization inpatients with from 2000 to 2010, using national insurance claim data. Overall, during these 10 years, number hospitalizations grew by compound annual growth rate 6.4%,...
Abstract Lung mast cells are important in host defense, and excessive proliferation or activation of these can cause chronic inflammatory disorders like asthma. Two parallel pathways induced by KIT–stem cell factor (SCF) FcεRI–immunoglobulin E interactions critical for the cells, respectively. Here, we report that cell-expressed membrane protein1 (MCEMP1), a lung-specific surface protein, functions as an adaptor KIT, which promotes SCF-mediated proliferation. MCEMP1 elicits intracellular...
Salt stress is a major constraint of crop productivity because it reduces yield and limits the expansion agriculture. This study investigated salt tolerance in 26 cultivars cut lilies (Lilium hybrids) by examining effect on growth morphological characteristics flowers leaves their physiological properties (chlorophyll fluorescence). significantly affected development lilies. Canonical discriminant analysis indicates that middle leaf width, number flowers, first flower diameter, petal...
Won Hee Kim, Pue Park, Jae A Jung, Ki Young Jung-Nam Suh, Oh Keun Kwon, Bong Sik Yoo, Su Lee, Pil Man Youn Jung Choi, O Hyeon Hye Ryun An, Ran and Yun-Im Kang. Korean J. Breed. Sci. 2020;52:161-9. https://doi.org/10.9787/KJBS.2020.52.S.161
This study investigated trends in lily ( Lilium hybrids) cultivars and challenges for growing cut flowers using a survey of producers the South Korean industry. A questionnaire requested information on various topics including total area, length farming experience, grown, factors considered when purchasing bulbs, cultivation systems, horticultural practices, disease pest problems, problems. The targeted membership Korea Lily Producer Association number respondents corresponded to 43% all...
In the context of aging, susceptibility to infectious diseases increases, leading heightened morbidity and mortality.This phenomenon, termed immunosenescence, is characterized by dysregulation in aging immune system, including abnormal alterations lymphocyte composition, elevated basal inflammation, accumulation senescent T cells.Such changes contribute increased autoimmune diseases, enhanced infection severity, reduced responsiveness vaccines.Utilizing animal models becomes imperative for a...
Patients with immune-mediated inflammatory diseases (IMIDs) like rheumatoid arthritis (RA) are at higher risk for severe COVID-19 and long-term complications in bone health. Emerging clinical evidence demonstrated that SARS-CoV-2 infection reduces turnover promotes loss, but the mechanism underlying worsened health remains elusive. This study sought to identify specific immune mediators exacerbated preexisting IMIDs after exposure. Plasma samples from 4 groups were analyzed: healthy, IMID...