A5030505939- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Rabies epidemiology and control
- SARS-CoV-2 detection and testing
- Bacillus and Francisella bacterial research
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- Microbial infections and disease research
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Prion Diseases and Protein Misfolding
- Neurological diseases and metabolism
- Animal Virus Infections Studies
- Clostridium difficile and Clostridium perfringens research
- Trace Elements in Health
- Toxoplasma gondii Research Studies
- Travel-related health issues
- Yersinia bacterium, plague, ectoparasites research
- Malaria Research and Control
- Gastrointestinal motility and disorders
- COVID-19 epidemiological studies
National Medical Center
2017-2024
Korea National Institute of Health
2011-2017
Korea Center for Disease Control and Prevention
2009-2014
Chungbuk National University
2009
Korea Disease Control and Prevention Agency
2009
The previous outbreaks of SARS-CoV and MERS-CoV have led researchers to study the role diagnostics in impediment further spread transmission. With recent emergence novel SARS-CoV-2, availability rapid, sensitive, reliable diagnostic methods is essential for disease control. Hence, we developed a reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay specific detection SARS-CoV-2. primer sets RT-LAMP were designed target nucleocapsid gene viral RNA, displayed limit 102...
Since severe acute respiratory syndrome-coronavirus-2 variant B.1.1.529 (omicron) was first reported to the World Health Organization on November 24, 2021, cases of omicron have been detected in more than 90 countries over last month. We investigated clinical and epidemiological characteristics 40 patients with who had isolated at National Medical Center South Korea during December 4-17, 2021. The median age 39.5 years. Twenty-two (55%) were women. Seventeen (42.5%) fully vaccinated, none...
An understanding of immune responses against the Middle East respiratory syndrome (MERS) is important for development treatments and preventive measures. Here, we investigated spectrum occurring in patients with MERS during early period infection.We obtained peripheral blood samples from 27 hospitalized recruited epidemic that occurred 2015 South Korea. Plasma cytokines/chemokines antibodies were quantified. Virus-specific T cells examined by intracellular cytokine staining after stimulation...
This nationwide, prospective cohort study evaluated pulmonary function and radiological sequelae according to infection severity in 73 survivors from the 2015 Middle East respiratory syndrome (MERS) outbreak Korea.Patients with severe pneumonia MERS-coronavirus had more impaired than those no or mild at 1-year follow-up, which was compatible sequelae.Severe significantly impairs makes long MERS.
Positive results from real-time reverse-transcription polymerase chain reaction (rRT-PCR) in recovered patients raise concern that who recover coronavirus disease 2019 (COVID-19) may be at risk of reinfection. Currently, however, evidence supports reinfection with severe acute respiratory syndrome 2 (SARS-CoV-2) has not been reported.We conducted whole-genome sequencing the viral RNA clinical specimens initial infection and positive retest 6 COVID-19 retested for SARS-CoV-2 via rRT-PCR after...
Cases of laboratory-confirmed SARS-CoV-2 reinfection have been reported in a number countries. Further, the level natural immunity induced by infection is not fully clear, nor it clear if primary protective against reinfection. To investigate potential association between serum antibody titres and SARS-CoV-2, ferrets with different levels NAb after were subjected to heterologous strain. All reinfected showed active virus replication upper respiratory gastro-intestinal tracts. However, high...
Omicron has become the globally dominant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, creating additional challenges due to its ability evade neutralization. Here, we report that neutralizing antibodies against variants are undetected following COVID-19 infection with ancestral or past SARS-CoV-2 variant viruses after two-dose mRNA vaccination. Compared vaccination, a three-dose vaccination course induces broad antibody responses improved durability different...
Abstract Background The immunologic features of children with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) are not clearly delineated. This study was conducted to evaluate SARS-CoV-2-specific antibody responses in COVID-19. Methods levels anti-spike (S) IgG, anti-SARS-CoV-2 and neutralizing (NAb) were measured during various time points <19 years age COVID-19 South Korea from February 2020 September 2020. Results One hundred sixty-five...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant (B.1.1.529) is dominating disease 2019 (COVID-19) worldwide. waning protective effect of available vaccines against the a critical public health issue. This study aimed to assess impact third COVID-19 vaccination on immunity SARS-CoV-2 BA.1 strain in older individuals.
Abstract Background Polymorphisms of the human prion protein gene ( PRNP ) contribute to genetic determinants Creutzfeldt-Jakob disease (CJD). Numerous polymorphisms in promoter regions as well open reading frame were investigated. Greater than 90% Korean, Chinese, and Japanese carry homozygote 129 MM codon. In Korea, have not been comprehensively studied, except codons 219 among Korean CJD cases. Although at play an important role susceptibility sporadic CJD, patients with other exhibited...
Concerns about the effectiveness of current vaccines against rapidly spreading severe acute respiratory syndrome-coronavirus-2 omicron (B.1.1.529) variant are increasing. This study aimed to assess neutralizing antibody activity wild-type (BetaCoV/Korea/KCDC03/2020), delta, and variants after full primary booster vaccinations with BNT162b2. A plaque reduction neutralization test was employed determine 50% dilution (ND
A 35-year-old man who returned from Germany developed fever, generalized pain, severe anal and skin rash, confirmed to be monkeypox (mpox). While he was previously human immunodeficiency virus infected, antiretroviral therapy ensured his immunocompetence. The mpox-related prodromal symptoms disappeared before isolation, subsequent several vesicular lesions healed after admission. moderate pain persisted for a few days, it improved during hospitalization. mpox no longer detected in samples...
Serum or plasma microRNAs (miRNAs) are potential biomarkers for the diagnosis cancer and prenatal diseases. This study was conducted to investigate whether rabies virus causes a change in serum miRNA expression. ICR mice were intramuscularly inoculated with sacrificed weekly collect brain tissue 4 weeks postinoculation. Mice assigned four groups based on results of indirect immunofluorescent assays, enzyme-linked immunosorbent assay, nested reverse transcription-polymerase chain reaction...
Human prion diseases are caused by abnormal accumulation of misfolded protein in the brain tissue. Inherited diseases, including familial Creutzfeldt-Jakob disease (fCJD), associated with mutations gene (PRNP). The glutamate (E)-to-lysine (K) substitution at codon 200 (E200K) PRNP is most common pathogenic mutation causing fCJD, but E200K alone regarded insufficient to cause diseases; thus, additional unidentified factors proposed explain penetrance E200K-dependent fCJD. Here, exome...
Background Rabies is a major public health problem with fatality rate close to 100%; however, complete prevention can be achieved through pre- or post-exposure prophylaxis. The rapid fluorescent focus inhibition test (RFFIT) one of the recommended testing methods determine production neutralizing antibodies after vaccination. Here, we report development new monoclonal antibody (mAb) designed react specifically virus (RABV) phosphoprotein (P protein), and evaluation its applicability RFFIT...
ObjectivesThe aim of this study was to investigate the seroprevalence antibodies against scrub typhus, murine typhus and spotted fever groups among North Korean refugees within 1 year their arrival in South Korea.MethodsWe recruited who had settled Korea after a short stay third country did not have any health problems. The antibody titer measured using commercial indirect fluorescence assay immunoglobulin G kit.ResultsThe 99 participants 22.2%, 17.2%, 10.1%, respectively, with 8.1% testing...
Human rabies is a reemerging infectious disease in Korea. There was no human case for 14 years until the had reoccurred 1999. To prevent occurrence of rabies, surveillance animal bite patients endemic areas Korea conducted since 2005 as part control program. The cases were analyzed to determine whether treated according post-exposure prophylaxis (PEP) guideline Centers Disease Control and Prevention.Information that occurred from 2009 high-risk regions collected by cooperation with Regional...
There are few data about long-term respiratory complications following Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection. This study aimed to evaluate functions and radiologic sequelae according the severity of infection one year after patients experienced MERS-CoV A total 73 undergoing during 2015 MERS outbreak in South Korea were enrolled this prospective multicenter study. Pulmonary function tests 6-minute walking performed 1 Radiologic was defined as fibrosis or...
Background: A global mpox outbreak occurred in 2022 and a domestic started South Korea April 2023. This study aimed to evaluate the clinical characteristics, viral shedding, immune response of Korea.Methods: Patients hospitalized with National Medical Center between September 2022, June 2023, were included this study. Oropharyngeal (OP), anogenital lesion (AL), skin (SL) swabs blood samples collected monkeypox virus (MPXV) DNA using real-time polymerase chain reaction (RT-PCR) culture assay...
We aimed to characterize the genomes of monkeypox virus isolates from Far East, providing insights into viral transmission and evolution. Genomic analysis was conducted on 8 obtained patients with disease in Republic Korea between May 2022 early 2023. These were classified Clade IIb. Distinct lineages, including B.1.1, A.2.1, B.1.3, observed 2023 isolates, only B.1.3 lineage detected six genetic features specific East (the Korea, Japan, Taiwan), distinguishing them diverse lineages found...