A5074064604- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- HIV/AIDS drug development and treatment
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- HIV Research and Treatment
- Mosquito-borne diseases and control
- interferon and immune responses
- Bacillus and Francisella bacterial research
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Molecular Biology Techniques and Applications
- Liver Disease and Transplantation
- Eosinophilic Disorders and Syndromes
- Microtubule and mitosis dynamics
- NF-κB Signaling Pathways
- Chronic Lymphocytic Leukemia Research
- Protist diversity and phylogeny
- Mast cells and histamine
- COVID-19 Clinical Research Studies
- Cellular transport and secretion
Amgen (United States)
2017-2024
University of Southern California
2013-2023
Pasteur Institute of Iran
2004-2012
Tarbiat Modares University
2008-2012
RWTH Aachen University
2007-2012
Shahid Beheshti University of Medical Sciences
2008-2012
Universitätsklinikum Aachen
2007-2011
Ospedale di Parma
2009
Ajou University
2009
Westfälische Hochschule
2008
Tenofovir is a new effective treatment option for patients with chronic hepatitis B, but could be potentially hampered by mutations in the B virus (HBV) polymerase conferring drug resistance. Drug resistance may occur preferentially if long-term administration required, example, e antigen (HBeAg)-negative HBV infection bearing precore (PC) and basal core promoter (BCP) mutations. The rtA194T mutation has been found HBV/HIV coinfected during tenofovir associated We generated...
The TRIpartite Motif (TRIM) family of RING-domain-containing proteins participate in a variety cellular functions. β-transducin repeat-containing protein (β-TrCP), component the Skp–Cullin–F-box-containing (SCF) E3 ubiquitin ligase complex, recognizes NF-κB inhibitor IκBα and precursor p100 for proteasomal degradation processing, respectively. β-TrCP thus plays critical role both canonical non-canonical activation. Here we report that TRIM9 is negative regulator Interaction between...
Hepatitis B virus (HBV) is one of the major causative agents acute and chronic liver disease worldwide believed to be responsible for a million deaths annually. Eight genotypes HBV, A H, have been described on basis similarity complete genomes sequence. Although, it reported that predominant HBV genotype in Mediterranean area middle east D, there are no reports prevalent Iran. In this study, C S regions from 26 hepatitis Iranian patients were amplified sequenced. Phylogenetic analysis...
Hepatitis B virus (HBV) is one of the main etiological agents acute and chronic liver disease that still a major public health problem in world. Numerous HBV isolates have grouped into eight genotypes, A to H, based on complete genome sequence. To date, no study has been carried out sequence Iran. The objective this was investigate organization phylogenetic analysis five strains, which obtained from Iranian infected patients. Results showed strains were closely related each other, with...
Significance Negative-strand RNA viruses are highly pathogenic and cause many severe diseases in humans animals. These generally use existing cellular pathways to enter cells, which involves intensive interaction with the endomembrane network, offering endocytic pathway as an attractive scheme for therapeutic intervention. Molecular mechanisms governing virus entry remain incompletely understood. We found that UV-radiation resistance-associated gene, well known regulating autophagy...
Immune escape variants of the hepatitis B virus (HBV) represent an emerging clinical challenge, because they can be associated with vaccine escape, HBV reactivation, and failure diagnostic tests. Recent data suggest a preferential selection immune mutants in distinct peripheral blood leukocyte compartments infected individuals. We therefore systematically analyzed functional impact most prevalent variants, sG145R sP120T mutants, on viral replication efficacy antiviral drug susceptibility...
AIM:To characterize the clinical, serologic and virologic features of hepatitis B virus (HBV) infection in Iranian patients with different stages liver disease. METHODS:Sixty two comprising 12 inactive carriers, 30 chronic patients, 13 cirrhosis 7 hepatocellular carcinoma (HCC) were enrolled study.The HBV S, C basal core promoter (BCP) regions amplified sequenced, serologic, phylogenetic characteristics investigated. RESULTS:The study group consisted 16 HBeAgpositive 46 HBeAg-negative...
AIM:To investigate the associations of hepatitis B virus (HBV) genotype with HBeAg and anti-HBe status, alanine aminotransferase (ALT) levels HBV-DNA detection in different groups HBV-infected patients southwest Iran.
Molecular evolutionary patterns of 62 HBV full-length genomes obtained from Belgian patients were characterized. Phylogenetic analysis revealed diverse subgenotypes including A2 and A6 (46.8%), D1-D4 (38.8%), E (9.7%), C1 (1.6%), B2 (1.6%). The study population consisted with different ethnic origin (Caucasian, Turkish, Asian, Arab, African). One D/C recombinant isolate was identified, which encoded subtype adw2. An subgenotype D4 an aberrant ayw4 detected. Although none the genotypes...
In spite of hepatitis B virus (HBV) vaccination, HBV infection remains an important public health problem worldwide. Although the genotype distribution has been determined in some parts South Central Asia, no survey conducted to determine Afghanistan. Twelve Afghan patients infected with living Afghanistan were enrolled this study. Partial HBsAg and basic core promoter, precore, (BCP/preC/C) regions amplified subjected for direct sequencing. parallel, precore G1896A mutation was also by...
Abstract The genetic diversity of the HBV S gene has a significant impact on prophylaxis and treatment hepatitis B infection. effect selective pressure this alteration not yet been studied in Iranian blood donors. To explore evolution to analyze effects patterns surface antigen (HBsAg) mutations screening assays, 358 donors diagnosed as asymptomatic carriers were enrolled nationwide study. Large partial genes amplified sequenced. (sub) genotypes synonymous nonsynonymous investigated....
A few reports exist on hepatitis B virus (HBV) genotype distribution in Iran; however the sample sizes of these studies are insufficient. The first objective this study was to determine HBV with a large size (147 specimens). second incidence lamivudine-resistant YMDD mutant profile among HBV-infected patients not treated lamivudine; some have reported that mutants detectable even before antiviral treatment.We used two cost-effective PCR-based methods been developed in-house: gap-PCR and...
Abstract Hepatitis B virus (HBV) and human immunodeficiency (HIV) have similar transmission routes, implying that patients infected with HIV are at particular risk for HBV infection. Patients who co‐infected progress more rapidly to end‐stage liver disease different genotypes may a distinct impact on progression. One hundred ninety‐one anti‐HBc‐positive sera from Belgian were collected during 1998–2008. Full‐length genomes as well large S or partial genes amplified their molecular...
Abstract Hepatitis B virus (HBV) isolates from Iranian patients around the country were characterized. Eighty‐one complete genomes HBV sequenced and analyzed. The studied population was grouped into three categories including inactive carriers, with chronic hepatitis, liver cirrhosis. Molecular phylogenetic analyses revealed that infected genotype D subgenotype D1. most common subtype ayw2 , followed by ayw3 ayw4 . Several deletions insertions had no correlation disease outcome observed in...
Abstract Lung mast cells are important in host defense, and excessive proliferation or activation of these can cause chronic inflammatory disorders like asthma. Two parallel pathways induced by KIT–stem cell factor (SCF) FcεRI–immunoglobulin E interactions critical for the cells, respectively. Here, we report that cell-expressed membrane protein1 (MCEMP1), a lung-specific surface protein, functions as an adaptor KIT, which promotes SCF-mediated proliferation. MCEMP1 elicits intracellular...