A5100613462- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Inflammasome and immune disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Plant tissue culture and regeneration
- Viral-associated cancers and disorders
- Osteoarthritis Treatment and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Music Therapy and Health
- Metabolism and Genetic Disorders
- Dietary Effects on Health
- Parvovirus B19 Infection Studies
- Healthcare Systems and Practices
- dental development and anomalies
- Kawasaki Disease and Coronary Complications
- Bone health and treatments
- Cancer-related gene regulation
- interferon and immune responses
- Diabetes Management and Education
- Health and Medical Research Impacts
- Global Healthcare and Medical Tourism
The University of Texas Medical Branch at Galveston
2021-2025
Cleveland Clinic Lerner College of Medicine
2021-2024
The University of Texas at Austin
2023-2024
University of Southern California
2016-2024
University of North Texas
2021
University of North Texas Health Science Center
2021
Boston University
2018-2020
University of Chicago Medical Center
2019
Molecular Oncology (United States)
2019
Public Health Department
2019
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a causative agent of the CoV disease 2019 (COVID-19) pandemic, enters host cells via interaction its receptor-binding domain (RBD) spike protein with angiotensin-converting enzyme (ACE2). Therefore, RBD is promising vaccine target to induce protective immunity against SARS-CoV-2 infection.
Thioredoxin-interacting protein (TXNIP) has emerged as a key player in cancer and diabetes since it targets thioredoxin (TRX)-mediated redox regulation glucose transporter (GLUT)-mediated metabolism. TXNIP consists of two arrestin (ARR, N-ARR C-ARR) domains at its amino-terminus PPxY (PY) motifs di-leucine (LL) motif for endocytosis carboxyl-terminus. Here, we report that shuffles between TRX GLUTs to regulate homeostasis intracellular oxidative stress While functions gatekeeper by default,...
Dabie bandavirus (DBV) is an emerging tick-borne virus that causes severe fever with thrombocytopenia syndrome (SFTS) in infected patients. Human SFTS symptoms progress from fever, fatigue, and muscle pain to the depletion of white blood cells platelets fatality rates up 30%. The recent spread its vector tick over 20 states United States increases potential for outbreaks beyond East Asia. Thus, development vaccine control this rapidly a high priority. In study, we applied self-assembling...
Tooth development is regulated by sequential and reciprocal epithelium-mesenchymal interactions their related molecular signaling pathways, such as bone morphogenetic proteins (BMPs). Among the 14 types of BMPs, BMP9 (also known growth differentiation factor 2) one most potent BMPs to induce osteogenic mesenchymal stem cells. The purpose this study was examine potential roles in tooth development. First, we detected expression pattern germ during postnatal development, found that widely...
Due to climate changes, there has been a large expansion of emerging tick-borne zoonotic viruses, including Heartland bandavirus (HRTV) and Dabie (DBV). As etiologic agents hemorrhagic fever with high fatality, HRTV DBV have recognized as dangerous viral pathogens that likely cause future wide epidemics. Despite serious health concerns, the mechanisms underlying infection are largely unknown. Gn Gc surface glycoproteins required for early entry events during infection. Glycosphingolipids,...
Managing diabetes in community clinics often presents substantial challenges. Diabetes group visits, shared medical appointments involving a clinician, offer potential solution to these However, there is need for training clinicians effectively lead and facilitate visits. The aim of this study develop assess program designed equip clinician learners with the skills Using ADDIE model (Analysis, Design, Development, Implementation, Evaluation) as guiding framework, we developed 3-hour virtual...
Abstract Lung mast cells are important in host defense, and excessive proliferation or activation of these can cause chronic inflammatory disorders like asthma. Two parallel pathways induced by KIT–stem cell factor (SCF) FcεRI–immunoglobulin E interactions critical for the cells, respectively. Here, we report that cell-expressed membrane protein1 (MCEMP1), a lung-specific surface protein, functions as an adaptor KIT, which promotes SCF-mediated proliferation. MCEMP1 elicits intracellular...
The oral cavity is the major site for transmission of Kaposi’s sarcoma-associated herpesvirus (KSHV), but how KSHV establishes infection and replication in epithelia remains unclear. Here, we report a spontaneous lytic model using fully differentiated, three-dimensional (3D) epithelial organoids at an air-liquid interface (ALI). This revealed that infected when basal cells were exposed by damage. Unlike two-dimensional (2D) cell culture, 3D organoid ALI culture allowed high levels...
Selective perturbation of protein interactions with chemical compounds enables dissection and control developmental processes. Differentiation stomata, cellular valves vital for plant growth survival, is specified by the basic-helix-loop-helix (bHLH) heterodimers. Harnessing a new amination reaction, we here report synthesis, derivatization, target identification, mode action an atypical doubly-sulfonylated imidazolone, Stomidazolone, which triggers stomatal stem cell arrest. Our forward...
Selective perturbation of protein interactions with chemical compounds enables dissection and control developmental processes. Differentiation stomata, cellular valves vital for plant growth survival, is specified by the basic-helix-loop-helix (bHLH) heterodimers. Harnessing a new amination reaction, we here report synthesis, derivatization, target identification, mode action an atypical doubly-sulfonylated imidazolone, Stomidazolone, which triggers stomatal stem cell arrest. Our forward...
TPS1639 Background: Racial and ethnic minority populations are underrepresented in cancer clinical trials. The USC Norris Comprehensive Cancer Center (USC NCCC) has multiple trial recruitment sites, including the Los Angeles General Medical (LAG), largest safety-net hospital western USA. LAG partners with to provide care underserved population of LAC, As a result, between 2015-2022 total 120 patients were accrued phase I trials; enrolled subjects 66% Hispanic, 21% Asian, 4% Black, 9% other....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a causative agent of COVID-19 pandemic, enters host cells via the interaction its Receptor-Binding Domain (RBD) Spike protein with Angiotensin-Converting Enzyme (ACE2). Therefore, RBD is promising vaccine target to induce protective immunity against SARS-CoV-2 infection. In this study, we report development protein-based candidate using self-assembling H. pylori -bullfrog ferritin nanoparticles as an antigen delivery. RBD-ferritin...
Abstract Tributyltin (TBT), a peroxisome proliferator-activated receptor γ (PPARγ)/retinoid X (RXR) ligand and founding member of the environmental obesogen chemical class, induces adipocyte differentiation suppresses bone formation. A growing number PPARγ ligands are being identified. However, potential for to induce adverse metabolic effects has been questioned because is therapeutic target in treatment type II diabetes. We evaluated molecular consequences TBT exposure during marrow...
Abstract Background Chemicals in disparate structural classes activate specific subsets of PPARγ’s transcriptional programs to generate adipocytes with distinct phenotypes. Objectives Our objectives were 1) establish a novel classification method predict PPARγ ligands and modifying chemicals, 2) create taxonomy group chemicals based on their effects transcriptome downstream metabolic functions. We tested the hypothesis that environmental adipogens highly ranked by taxonomy, but segregated...
Notch receptors are transmembrane glycoproteins of a highly conserved signaling pathway that is crucial in regulation multiple cell differentiation and developmental processes multicellular organisms. There four higher eukaryotic organisms, aberrant any these associated with many types diseases. The protein has modular domain structure consisting an extracellular contains the ligand binding negative regulatory region (NRR), intracellular domain. NRR composed three tandem LIN-12/Notch-Repeats...